UCHL5 and KRT12

Number of citations of the paper that reports this interaction (PubMedID 21800051)
0

Data Source:
BioGRID (pull down)

		UCHL5	KRT12
Description		ubiquitin C-terminal hydrolase L5	keratin 12
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex	Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding	Structural Molecule Activity Structural Constituent Of Skin Epidermis
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Morphogenesis Of An Epithelium Visual Perception Epithelial Cell Differentiation Intermediate Filament Organization Cornea Development In Camera-type Eye
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases	Keratinization Formation of the cornified envelope
Drugs			Griseofulvin Anthralin
Diseases			Meesmann corneal dystrophy
GWAS		Cannabis dependence ( 21668797)
Interacting Genes		104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1	1 interacting genes: UCHL5
Entrez ID		51377	3859
HPRD ID		10293	03405
Ensembl ID		ENSG00000116750	ENSG00000187242
Uniprot IDs		Q5LJA5 Q9Y5K5	Q99456
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?		CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Signal Transduction Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Neurofibrillary Tangle Assembly Leukocyte Proliferation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Inclusion Body Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Complement-dependent Cytotoxicity Central Nervous System Myelin Maintenance Neurofibrillary Tangle Chromaffin Granule Regulation Of Neuronal Signal Transduction Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Immune Complex Clearance Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Spherical High-density Lipoprotein Particle Positive Regulation Of Cell Communication Signaling Receptor Binding Microglial Cell Proliferation Protein Import Regulation Of Protein Catabolic Process Positive Regulation Of Signaling Protein Heterodimerization Activity Regulation Of Proteolysis Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Immature T Cell Proliferation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB4 Signaling Pathway Forebrain Morphogenesis Protein Carrier Chaperone Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Amyloid Fibril Formation Protein Targeting To Vacuole Involved In Autophagy Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement Activation Response To Misfolded Protein Semaphorin Receptor Complex Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Telomere Maintenance In Response To DNA Damage
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