TRIM63 and USP5

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		TRIM63	USP5
Gene Name		tripartite motif containing 63, E3 ubiquitin protein ligase	ubiquitin specific peptidase 5 (isopeptidase T)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Lysosome
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Zinc Ion Binding
	Biological Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus	Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	22 interactors: APP DAZAP2 DVL2 PJA1 PLA2G2A RFFL RNF11 STK33 TADA3 TMEM239 TRAF6 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIML1 UBC UBE2S UBTD2 USP28
Entrez ID		84676	8078
HPRD ID		05843	03265
Ensembl ID		ENSG00000158022	ENSG00000111667
Uniprot IDs		B4DN95 Q969Q1	P45974
PDB IDs		2D8U 3DDT	2DAG 2DAK 2G43 2G45 3IHP
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Viral Release From Host Cell Apoptotic Process Negative Regulation Of Viral Entry Into Host Cell Programmed Cell Death Proteolysis Cell Death Regulation Of Lipopolysaccharide-mediated Signaling Pathway Death Regulation Of Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteolysis Regulation Of Viral Release From Host Cell Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Response To Cytokine Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Activation Of Innate Immune Response Cellular Metabolic Process Innate Immune Response Positive Regulation Of MAPK Cascade Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Phosphorylation Cytokine-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Defense Response Protein Autoubiquitination
Tagcloud ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	acquired add already alternate alters braf checkpoint damaging deubiquitinase dub eoai3402143 fas intrinsically knockdown mek melanoma modulating nras overcame p73 phenocopied restored sensitization sensitized strand suppress ub unanchored vemurafenib
Tagcloud (Difference) ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	acquired add already alternate alters braf checkpoint damaging deubiquitinase dub eoai3402143 fas intrinsically knockdown mek melanoma modulating nras overcame p73 phenocopied restored sensitization sensitized strand suppress ub unanchored vemurafenib
Tagcloud (Intersection) ?