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TRIM63 and TSC2
Number of citations of the paper that reports this interaction (PubMedID
31391242
)
0
Data Source:
BioGRID
(two hybrid)
TRIM63
TSC2
Description
tripartite motif containing 63
TSC complex subunit 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Microtubule
Z Disc
M Band
Contractile Muscle Fiber
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Golgi Apparatus
Cytosol
Postsynaptic Density
Membrane
TSC1-TSC2 Complex
Synapse
Perinuclear Region Of Cytoplasm
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Titin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
GTPase Activator Activity
Protein Binding
Phosphatase Binding
Small GTPase Binding
Protein Homodimerization Activity
Hsp90 Protein Binding
Biological Process
Muscle Contraction
Signal Transduction
Negative Regulation Of Cardiac Muscle Hypertrophy
Skeletal Muscle Atrophy
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Protein Ubiquitination
Innate Immune Response
Negative Regulation Of Glycolytic Process
Response To Glucocorticoid
Response To Interleukin-1
Neural Tube Closure
Cytoplasmic Translation
Protein Import Into Nucleus
Endocytosis
Heart Development
Intracellular Protein Localization
Negative Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Vesicle-mediated Transport
Positive Regulation Of Macroautophagy
Regulation Of Macroautophagy
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
TORC1 Signaling
Anoikis
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cell Cycle
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Mitophagy
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Pathways
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Antigen processing: Ubiquitination & Proteasome degradation
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
TBC/RABGAPs
Drugs
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
White blood cell count (
32888494
)
Interacting Genes
331 interacting genes:
ACBD4
ACD
ACTA1
ADAMTSL4
AEBP2
AGO2
AK1
AKR7A2
ALDOA
ALKBH3
ANKRD1
ANKRD39
APLN
APOBEC4
APP
ARL6IP4
ATP5F1B
ATP5F1D
ATXN3
ATXN3L
ATXN7L1
BAP1
BCAT1
BCHE
BRD4
BRWD1
BTBD9
C10orf88
C1orf35
C3orf36
C8orf74
CADPS
CAMK2A
CAPN3
CARS1
CBX2
CCDC120
CCDC28B
CDK3
CDS2
CENPK
CHMP7
CKB
CKM
COA7
COX4I1
CRCT1
CTAG1A
CTAG1B
CTNNB1
CYB5R2
CYP46A1
CYTOR
DAPL1
DCAF11
DCAF6
DECR2
DEF8
DEK
DES
DMD
DNTTIP1
DOCK7
DYNLT2B
EED
EEF1G
EHHADH
EIF3E
ELAPOR1
ENO3
EPS8L2
ESPL1
EZH2
FAM185A
FANK1
FASTKD1
FERRY3
FHL2
FKBP6
FLNC
FRMD6
FYN
GABPB1
GATA3
GFM1
GLI4
GMEB1
GOLGA2P5
GPRIN2
GPS1
GRB10
HIBADH
HID1
HIRA
HOXA1
HROB
HSPB1
HSPD1
ID1
IFI35
IGF2
IK
IL37
ILF3
INCA1
ING4
INKA1
IQUB
IRF2
IRF3
ITGB5
JADE3
JOSD1
KBTBD4
KCTD15
KIAA0087
KIAA0408
KIAA0825
KIF5A
KLHDC4
KLHL36
KMT2B
KYAT1
LAMA2
LAMTOR5
LAPTM4A
LIMS2
LINC00518
LINC00663
LINC00905
LINC01588
LMCD1
LMO2
LRRC56
LYN
LYNX1
MAGEC3
MALSU1
MAP3K14
MBD4
MBIP
MCM7
MIDN
MIIP
MKI67
MLH3
MPP1
MPZL1
MRPL19
MRPL20-AS1
MRPL41
MSRB3
MYBPC1
MYBPC2
MYBPC3
MYBPHL
MYC
MYCT1
MYH6
MYL2
MYOT
MYOZ1
NDUFA1
NDUFA8
NEB
NEBL
NEFL
NGEF
NOMO1
NR1D2
NRAP
NSD3
NSUN7
NUFIP2
ODF2
OGFOD2
OTUB1
OTUB2
P3H3
PACRGL
PAFAH1B2
PCGF3
PCGF6
PDHB
PDK4
PELI3
PELO
PHC2
PHF23
PIAS1
PIAS2
PIAS3
PIP4K2B
PKM
PLEKHG4
PLXNA3
POLR2E
PPA2
PPARA
PPIE
PRKAB2
PRKACA
PRR30
PRRT1
PSMD4
PYGM
RAI2
RBM14
RELA
REX1BD
RGR
RHEB
RHPN1
RING1
RNASEH1
RNF10
RPS4X
RRAS
RUSC1
RUSC1-AS1
SEC23B
SENP2
SENP3
SET
SGCB
SHFL
SLC6A13
SLFN12
SNAPIN
SNW1
SPATS1
SPRYD7
SPSB1
SPSB2
SQSTM1
SRF
STAM
SUMO2
SYMPK
SYNCRIP
TCAP
TCEAL4
TCP10L
TEX19
THAP3
THRA
TIGD5
TIMM17B
TMBIM1
TMEM35A
TNIP3
TNNC1
TNNI1
TNNI2
TNNI3
TNNT1
TNNT3
TOR1AIP2
TPD52L3
TRAF3IP2
TRIB3
TRIM23
TRIM35
TRIM41
TRIM54
TRIM55
TRIM69
TRMT10B
TSC2
TSC22D4
TTN
TUBGCP4
UBA3
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2G1
UBE2I
UBE2J1
UBE2K
UBE2N
UBE2U
UBE2V2
UCHL1
UCHL3
UCHL5
UNKL
UQCRC1
USP13
USP15
USP2
USP21
USP28
USP33
USP4
USP5
USP7
USP8
UXT
VAC14
VPS37A
WT1
XAGE1B
YJU2B
YOD1
YPEL3
ZBTB17
ZC2HC1C
ZC3H12A
ZC3HC1
ZFYVE19
ZNF124
ZNF20
ZNF302
ZNF333
ZNF345
ZNF431
ZNF436
ZNF460
ZNF566
ZNF57
ZNF581
ZNF597
ZNF649
ZNF653
ZNF667-AS1
ZNF767P
ZNF775
ZNF83
ZSCAN16
61 interacting genes:
ACTN2
AKT1
AKT2
AKT3
ANKRD35
BTG3
CALM1
CBY2
CCND1
CDKN1B
EEF1A1
ESR1
FBXL6
FBXW5
GAPDH
GRB2
GSK3B
LNX1
MAPK1
MAPK3
MAPKAPK2
MDFI
MKRN1
MRPL21
NEK1
PAM
PHLDB1
PICK1
PIN1
PLK2
PPP1CA
PPP2CA
PRKAA1
PTK2
PTPN11
RAB5A
RABEP1
RHEB
RPL4
RPS6KA1
RPSA
SEPTIN4
SERPINI1
SFN
SLC13A3
SMAD2
SMAD3
SSC4D
SUPT6H
TK1
TRIM55
TRIM63
TSC1
UBE3A
USPL1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
84676
7249
HPRD ID
05843
01850
Ensembl ID
ENSG00000158022
ENSG00000103197
Uniprot IDs
Q969Q1
A0A2R8Y6C9
A0A2R8YDZ2
B3KWH7
H3BMQ0
P49815
Q5HYF7
X5D2U8
X5D7Q2
PDB IDs
2D8U
3DDT
4M3L
7DL2
9CE3
Enriched GO Terms of Interacting Partners
?
Post-translational Protein Modification
Cysteine-type Deubiquitinase Activity
Protein Modification By Small Protein Removal
Protein Deubiquitination
Cysteine-type Peptidase Activity
Protein Binding
Sarcomere Organization
Protein Modification By Small Protein Conjugation
Protein Modification Process
Structural Constituent Of Muscle
Troponin Complex
Nucleus
Actomyosin Structure Organization
Striated Muscle Contraction
Z Disc
Cardiac Muscle Contraction
Ubiquitin Conjugating Enzyme Activity
Protein K48-linked Deubiquitination
Ubiquitin Protein Ligase Binding
Contractile Muscle Fiber
Sarcomere
Protein Ubiquitination
Troponin T Binding
Protein Metabolic Process
Myofibril
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Skeletal Muscle Contraction
Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Deubiquitinase Activity
Proteolysis
Negative Regulation Of RNA Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
TORC1 Signaling
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
TOR Signaling
K48-linked Deubiquitinase Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
Myofibril Assembly
Nucleoplasm
Cardiac Muscle Tissue Morphogenesis
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Muscle Contraction
Cytosol
Titin Binding
Intracellular Signal Transduction
Protein Modification Process
Protein Metabolic Process
Phosphoserine Residue Binding
Regulation Of TOR Signaling
Cytosol
TOR Signaling
Negative Regulation Of TOR Signaling
Protein Kinase Binding
Cytoplasm
TORC1 Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Biological Quality
Intracellular Signaling Cassette
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Regulation Of Signal Transduction
Protein Domain Specific Binding
Macromolecule Metabolic Process
Cellular Response To Stress
Protein Sequestering Activity
Ciliary Basal Body
Identical Protein Binding
Insulin Receptor Signaling Pathway
Signal Transduction
Protein Kinase Activity
Cellular Response To Nutrient Levels
Positive Regulation Of TOR Signaling
Kinase Activity
Protein Phosphorylation
Protein Serine Kinase Activity
Regulation Of Synaptic Plasticity
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Protein Stability
Negative Regulation Of Catabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Organelle Organization
Epidermal Growth Factor Receptor Signaling Pathway
Phosphorylation
Negative Regulation Of Signaling
Positive Regulation Of TORC1 Signaling
Negative Regulation Of Cell Communication
Nucleus
Regulation Of Immune Response
Regulation Of Protein Metabolic Process
Protein Serine/threonine Kinase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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