UCHL5 and HAUS7

Number of citations of the paper that reports this interaction (PubMedID 11163772)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		UCHL5	HAUS7
Description		ubiquitin C-terminal hydrolase L5	HAUS augmin like complex subunit 7
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex	Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Ciliary Basal Body HAUS Complex Mitotic Spindle Microtubule
	Molecular Function	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding	Protein Binding Thioesterase Binding Microtubule Minus-end Binding
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Centrosome Cycle Regulation Of Microtubule Nucleation Microtubule Organizing Center Organization Spindle Assembly Cell Division
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Cannabis dependence ( 21668797)
Interacting Genes		104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1	4 interacting genes: ATF4 CSNK1E DPPA3 UCHL5
Entrez ID		51377	55559
HPRD ID		10293	18695
Ensembl ID		ENSG00000116750	ENSG00000213397
Uniprot IDs		Q5LJA5 Q9Y5K5	Q99871
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP	7SQK
Enriched GO Terms of Interacting Partners?		CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding	Circadian Regulation Of Gene Expression Lewy Body Core Response To Manganese-induced Endoplasmic Reticulum Stress ATF1-ATF4 Transcription Factor Complex L-asparagine Metabolic Process CHOP-ATF4 Complex Positive Regulation Of Sodium-dependent Phosphate Transport Circadian Rhythm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Epigenetic Programing Of Female Pronucleus GDF15-GFRAL Signaling Pathway ATF4-CREB1 Transcription Factor Complex Negative Regulation Of Translational Initiation In Response To Stress Asparagine Metabolic Process Regulation Of Sodium-dependent Phosphate Transport Regulation Of Proteasomal Protein Catabolic Process Rhythmic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process PERK-mediated Unfolded Protein Response HRI-mediated Signaling Cellular Response To Leucine Starvation Lens Fiber Cell Morphogenesis Regulation Of Phosphate Transport Mitochondrial Respirasome Assembly Response To Manganese Ion Cellular Response To Stress Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway CAMP Response Element Binding Protein Binding Cellular Response To Manganese Ion General Transcription Initiation Factor Binding Regulation Of Protein Metabolic Process Leucine Zipper Domain Binding Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteolysis Ino80 Complex Forebrain Morphogenesis Positive Regulation Of Telomere Maintenance In Response To DNA Damage Lateral Ventricle Development Male Pronucleus Female Pronucleus Epigenetic Programming In The Zygotic Pronuclei Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Nuclear Periphery Positive Regulation Of Smooth Muscle Cell Apoptotic Process Proteasome Binding Regulation Of DNA Strand Elongation Histone H3K9me2/3 Reader Activity
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