UCHL5 and EPPK1

Number of citations of the paper that reports this interaction (PMID 21800051)
0

Data Source:
BioGRID (pull down)

		UCHL5	EPPK1
Gene Name		ubiquitin carboxyl-terminal hydrolase L5	epiplakin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol Ino80 Complex	Cytoplasm Cytoskeleton
	Molecular Function	Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Omega Peptidase Activity Poly(A) RNA Binding Proteasome Binding	Poly(A) RNA Binding
	Biological Process	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Midbrain Development Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process	Biological_process
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Cannabis dependence ( 21668797)
Protein-Protein Interactions		96 interactors: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 HAUS7 HBA1 HBA2 HBB HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBE3A USP28 YWHAZ ZBED1	2 interactors: EGFR UCHL5
Entrez ID		51377	83481
HPRD ID		10293	06500
Ensembl ID		ENSG00000116750
Uniprot IDs		Q9Y5K5
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3
Enriched GO Terms of Interacting Partners?		Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Regulation Of Megakaryocyte Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation CENP-A Containing Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly Demethylation Centromere Complex Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing DNA Methylation Nucleosome Organization Nucleosome Assembly Chromatin Assembly Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Component Assembly Regulation Of Myeloid Cell Differentiation DNA Conformation Change Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Keratinocyte Differentiation Cellular Protein Metabolic Process Homeostatic Process	Alkanesulfonate Metabolic Process Telencephalon Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Protein Catabolic Process Activation Of Phospholipase A2 Activity Forebrain Development Positive Regulation Of Phospholipase A2 Activity Response To Cobalamin Response To UV-A Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Catenin Import Into Nucleus Regulation Of Phospholipase A2 Activity Regulation Of Superoxide Anion Generation Brain Development Head Development Magnesium Ion Homeostasis Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Estradiol Stimulus Protein Insertion Into Membrane Astrocyte Development Central Nervous System Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Organ Morphogenesis Forebrain Morphogenesis Regulation Of Catenin Import Into Nucleus Lateral Ventricle Development Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Signal Transduction Response To Epidermal Growth Factor Cellular Response To Estrogen Stimulus Negative Regulation Of Signaling Cellular Response To Dexamethasone Stimulus Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Hydrogen Peroxide Metabolic Process Morphogenesis Of An Epithelial Fold Response To Dexamethasone Positive Regulation Of DNA Repair Tongue Development Regulation Of Nitric-oxide Synthase Activity Astrocyte Differentiation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Tagcloud ?			arid1a bisphosphate cholangiocarcinoma cirrhosis designing driver ece2 exclusively fatal fyn hbsag icc idh1 intrahepatic kras matching mutational phosphatidylinositol plc plcs seronegative seropositive signalling signature smad substantially tp53 transforming uncover
Tagcloud (Difference) ?			arid1a bisphosphate cholangiocarcinoma cirrhosis designing driver ece2 exclusively fatal fyn hbsag icc idh1 intrahepatic kras matching mutational phosphatidylinositol plc plcs seronegative seropositive signalling signature smad substantially tp53 transforming uncover
Tagcloud (Intersection) ?