UCHL5 and EIF4A1

Number of citations of the paper that reports this interaction (PubMedID 21800051)
0

Data Source:
BioGRID (pull down)

		UCHL5	EIF4A1
Description		ubiquitin C-terminal hydrolase L5	eukaryotic translation initiation factor 4A1
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Nuclear Stress Granule
	Molecular Function	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding	Nucleotide Binding RNA Cap Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Cytoplasmic Translational Initiation Translation Translational Initiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs			Copper
Diseases
GWAS		Cannabis dependence ( 21668797)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1	19 interacting genes: CEBPA EIF4G1 EIF4G2 EIF4G3 FAM107A FTCD LIG4 MAPK6 OGT PAIP1 PDCD4 PLPPR4 PRMT5 RIPPLY3 SUMO2 TNKS UCHL5 UPF2 WDR77
Entrez ID		51377	1973
HPRD ID		10293	04030
Ensembl ID		ENSG00000116750	ENSG00000161960
Uniprot IDs		Q5LJA5 Q9Y5K5	P60842
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP	2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW 7PPZ 7PQ0 8HUJ 8OZ0 8XXN 9AVR 9BLN 9DTS
Enriched GO Terms of Interacting Partners?		CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding	Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Protein Metabolic Process Translation Factor Activity, RNA Binding Translational Initiation Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Translation Initiation Factor Activity Positive Regulation Of Translation Animal Organ Regeneration Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Translation Methylosome Lateral Ventricle Development Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lithium Ion Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Regulation Of Developmental Process Response To Lithium Ion RNA Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Liver Development Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Cytosol Methyl-CpG Binding Regeneration Positive Regulation Of MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Nucleus Translation Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Proteolysis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Developmental Process
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