UCHL5 and EIF4A1

Number of citations of the paper that reports this interaction (PMID 21800051)
0

Data Source:
BioGRID (pull down)

		UCHL5	EIF4A1
Gene Name		ubiquitin carboxyl-terminal hydrolase L5	eukaryotic translation initiation factor 4A1
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Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol Ino80 Complex	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Omega Peptidase Activity Poly(A) RNA Binding Proteasome Binding	RNA Cap Binding Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Midbrain Development Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Gene Expression Viral Process Cytokine-mediated Signaling Pathway Organ Regeneration Cellular Protein Metabolic Process
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Translation initiation complex formation Translation Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation
Drugs
Diseases
GWAS		Cannabis dependence ( 21668797)
Protein-Protein Interactions		96 interactors: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 HAUS7 HBA1 HBA2 HBB HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBE3A USP28 YWHAZ ZBED1	10 interactors: EIF4G1 EIF4G2 EIF4G3 LIG4 LPPR4 MAPK6 PAIP1 PRMT1 UCHL5 UPF2
Entrez ID		51377	1973
HPRD ID		10293	04030
Ensembl ID		ENSG00000116750	ENSG00000161960
Uniprot IDs		Q9Y5K5	P60842
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3	2G9N 2ZU6 3EIQ
Enriched GO Terms of Interacting Partners?		Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Regulation Of Megakaryocyte Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation CENP-A Containing Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly Demethylation Centromere Complex Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing DNA Methylation Nucleosome Organization Nucleosome Assembly Chromatin Assembly Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Component Assembly Regulation Of Myeloid Cell Differentiation DNA Conformation Change Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Keratinocyte Differentiation Cellular Protein Metabolic Process Homeostatic Process	Translational Initiation Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Translation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Metabolic Process Cellular Macromolecule Catabolic Process DNA Ligation Involved In DNA Recombination Cellular Protein Metabolic Process MRNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytokine-mediated Signaling Pathway Aromatic Compound Catabolic Process RNA 3'-end Processing Regulation Of Protein Metabolic Process Gene Expression MRNA Metabolic Process Viral Process Cellular Macromolecule Biosynthetic Process Cellular Response To Cytokine Stimulus Macromolecule Biosynthetic Process Negative Regulation Of Megakaryocyte Differentiation Protein Metabolic Process Lagging Strand Elongation Pro-B Cell Differentiation Response To Cytokine Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Establishment Of Integrated Proviral Latency Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Immunoglobulin V(D)J Recombination Establishment Of Viral Latency DNA Recombination T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Metabolic Process Catabolic Process Lymphoid Progenitor Cell Differentiation Peptidyl-arginine N-methylation Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Histone H4-R3 Methylation RNA Metabolic Process DNA Ligation Cellular Response To Stimulus
Tagcloud ?			classes constituents cycling cyclins dexd dysregulation eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 pdcd4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Difference) ?			classes constituents cycling cyclins dexd dysregulation eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 pdcd4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Intersection) ?