UCHL5 and ACTN4

Number of citations of the paper that reports this interaction (PubMedID 21800051)
0

Data Source:
BioGRID (pull down)

		UCHL5	ACTN4
Description		ubiquitin C-terminal hydrolase L5	actinin alpha 4
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynaptic Actin Cytoskeleton Ribonucleoprotein Complex
	Molecular Function	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases	Platelet degranulation Nephrin family interactions
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Cannabis dependence ( 21668797)	Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 34074324) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)
Interacting Genes		104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1	60 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A CEBPA COIL COL17A1 DDIAS DSCAM DSCR9 ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NHERF2 NOS2 NOS3 PDE4B PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RNF10 RPS27 SACS SERPINE1 SLC2A4 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR
Entrez ID		51377	81
HPRD ID		10293	05222
Ensembl ID		ENSG00000116750	ENSG00000130402
Uniprot IDs		Q5LJA5 Q9Y5K5	A0A0S2Z3G9 F5GXS2 H7C144 O43707
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP	1WLX 1YDI 2R0O 6O31 6OA6
Enriched GO Terms of Interacting Partners?		CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding	Z Disc Actomyosin Structure Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Calmodulin Binding Actin Cytoskeleton Organization Actin Cytoskeleton Positive Regulation Of Metabolic Process Developmental Process Cytoplasm Actin Filament-based Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Macromolecule Biosynthetic Process Telethonin Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Myofibril Assembly Protein Kinase Binding Anatomical Structure Formation Involved In Morphogenesis Cytoskeleton Organization Actin Binding Anatomical Structure Morphogenesis Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Organization Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Cytokine Production Sarcomere Organization Regulation Of Calcium Ion Transport Actinin Binding Circulatory System Process Structural Constituent Of Muscle Regulation Of Angiogenesis Cardiac Myofibril Assembly Alpha-actinin Binding Negative Regulation Of Developmental Process
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