UCHL5 and ANXA4

Number of citations of the paper that reports this interaction (PMID 21800051)
0

Data Source:
BioGRID (pull down)

		UCHL5	ANXA4
Gene Name		ubiquitin carboxyl-terminal hydrolase L5	annexin A4
Image
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol Ino80 Complex	Nucleus Cytoplasm Plasma Membrane Cell Surface Vesicle Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Omega Peptidase Activity Poly(A) RNA Binding Proteasome Binding	Phospholipase Inhibitor Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Calcium-dependent Protein Binding NF-kappaB Binding
	Biological Process	DNA Repair DNA Recombination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Lateral Ventricle Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Midbrain Development Forebrain Morphogenesis Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Interleukin-8 Secretion
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Cannabis dependence ( 21668797)	Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		96 interactors: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 HAUS7 HBA1 HBA2 HBB HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4A HIST2H4B HIST4H4 HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBE3A USP28 YWHAZ ZBED1	7 interactors: GP2 NMT2 PADI4 POT1 SMPD1 TINF2 UCHL5
Entrez ID		51377	307
HPRD ID		10293	00112
Ensembl ID		ENSG00000116750	ENSG00000196975
Uniprot IDs		Q9Y5K5	P09525 Q6LES2 Q6P452
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3	2ZOC
Enriched GO Terms of Interacting Partners?		Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Regulation Of Megakaryocyte Differentiation DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation CENP-A Containing Nucleosome Assembly Chromatin Silencing DNA Replication-independent Nucleosome Assembly Demethylation Centromere Complex Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing DNA Methylation Nucleosome Organization Nucleosome Assembly Chromatin Assembly Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Component Assembly Regulation Of Myeloid Cell Differentiation DNA Conformation Change Chromatin Remodeling Negative Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Keratinocyte Differentiation Cellular Protein Metabolic Process Homeostatic Process	Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Antigen Transcytosis By M Cells In Mucosal-associated Lymphoid Tissue Negative Regulation Of DNA Metabolic Process Regulation Of Protein ADP-ribosylation N-terminal Peptidyl-glycine N-myristoylation Histone Citrullination Histone H3-R26 Citrullination Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Telomere Formation Via Telomerase Negative Regulation Of Protein Glycosylation Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Protein Citrullination Regulation Of Chromosome Organization Negative Regulation Of Protein Metabolic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Helicase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Sphingomyelin Catabolic Process Citrulline Biosynthetic Process Chromosome Organization DNA Metabolic Process N-terminal Protein Myristoylation DNA Conformation Change Regulation Of Protein Glycosylation Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Protein Myristoylation Citrulline Metabolic Process Viral Protein Processing Negative Regulation Of Transferase Activity Transcytosis Negative Regulation Of Glycoprotein Metabolic Process Sphingomyelin Metabolic Process Regulation Of Telomerase Activity
Tagcloud ?			anxa2 calbindin1 cascades categorized cofilin1 cytoskeleton ddah2 differentially dj e40 e70 e93 electrophoresis elucidated embryonic expressional fetoprotein functionally grp75 kidney kidneys pig proteomic representative serves sod2 subjected tandem vil1
Tagcloud (Difference) ?			anxa2 calbindin1 cascades categorized cofilin1 cytoskeleton ddah2 differentially dj e40 e70 e93 electrophoresis elucidated embryonic expressional fetoprotein functionally grp75 kidney kidneys pig proteomic representative serves sod2 subjected tandem vil1
Tagcloud (Intersection) ?