TRIM63 and USP13

Number of citations of the paper that reports this interaction (PMID 11927605)
45

Data Source:
HPRD (in vitro, two hybrid)

		TRIM63	USP13
Gene Name		tripartite motif containing 63, E3 ubiquitin protein ligase	ubiquitin specific peptidase 13 (isopeptidase T-3)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Lysosome
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Zinc Ion Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding
	Biological Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus	Regulation Of Transcription, DNA-templated Autophagy Cell Proliferation Regulation Of Autophagy Melanocyte Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	12 interactors: DVL1 FNBP1L FUNDC2 LAPTM5 MRPL20 MYO15A PTEN SIAH2 SPRR2C TRIM55 TRIM63 UBC
Entrez ID		84676	8975
HPRD ID		05843	04666
Ensembl ID		ENSG00000158022	ENSG00000058056
Uniprot IDs		B4DN95 Q969Q1	Q92995
PDB IDs		2D8U 3DDT	2L80 2LBC
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination	Prepulse Inhibition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Catabolic Process Startle Response Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Social Behavior Regulation Of Proteolysis Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Projection Morphogenesis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Membrane Organization Cell Part Morphogenesis Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ligase Activity Regulation Of Protein Catabolic Process Dendrite Morphogenesis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Canonical Wnt Signaling Pathway Activation Of APC-Cdc20 Complex Activity Postsynaptic Density Assembly Negative Regulation Of Presynaptic Membrane Organization Inner Ear Morphogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Morphogenesis Negative Regulation Of Signal Transduction T Cell Receptor Signaling Pathway Regulation Of Cell Projection Organization Ubiquitin-dependent Protein Catabolic Process Cell Projection Organization Convergent Extension Involved In Neural Plate Elongation Negative Regulation Of Dendritic Spine Morphogenesis Vesicle Transport Along Actin Filament Modification-dependent Protein Catabolic Process
Tagcloud ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	adamts2 aldh1a3 alpl2 apod cabin1 casp10 cdh16 classes classifier clgn covering crabp1 dataset datasets enrichments follicular gnas hmgb2 krthb5 microfollicular nr2f2 nras pax8 predictions sdha separating similarities subclasses timp1
Tagcloud (Difference) ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	adamts2 aldh1a3 alpl2 apod cabin1 casp10 cdh16 classes classifier clgn covering crabp1 dataset datasets enrichments follicular gnas hmgb2 krthb5 microfollicular nr2f2 nras pax8 predictions sdha separating similarities subclasses timp1
Tagcloud (Intersection) ?