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MAP1LC3B and SQSTM1
Number of citations of the paper that reports this interaction (PubMedID
37658135
)
54
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(two hybrid)
MAP1LC3B
SQSTM1
Description
microtubule associated protein 1 light chain 3 beta
sequestosome 1
Image
GO Annotations
Cellular Component
Autophagosome Membrane
Cytoplasm
Mitochondrion
Autophagosome
Cytosol
Cytoskeleton
Microtubule
Axoneme
Endomembrane System
Membrane
Organelle Membrane
Cytoplasmic Vesicle
Mitochondrial Membrane
Phagophore Assembly Site
P-body
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Lysosome
Endosome
Late Endosome
Autophagosome
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Sarcomere
Cytoplasmic Vesicle
Intracellular Membraneless Organelle
Amphisome
Autolysosome
Synapse
Extracellular Exosome
Sperm Midpiece
Lewy Body
Glutamatergic Synapse
Molecular Function
Protein Binding
Phospholipid Binding
Microtubule Binding
Phosphatidylethanolamine Binding
Ubiquitin Protein Ligase Binding
Ceramide Binding
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Ionotropic Glutamate Receptor Binding
Signaling Receptor Activity
SH2 Domain Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Ubiquitin-modified Protein Reader Activity
Protein Sequestering Activity
Molecular Sequestering Activity
Molecular Condensate Scaffold Activity
Biological Process
Autophagosome Assembly
Autophagy Of Mitochondrion
Mitophagy
Autophagy
Cellular Response To Nitrogen Starvation
Cellular Response To Starvation
Macroautophagy
Autophagosome Maturation
Negative Regulation Of Transcription By RNA Polymerase II
Autophagy Of Mitochondrion
Mitophagy
Pexophagy
Temperature Homeostasis
Immune System Process
Response To Ischemia
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Import Into Nucleus
Autophagy
Apoptotic Process
Endosome Organization
Intracellular Protein Localization
Positive Regulation Of Autophagy
Regulation Of Mitochondrion Organization
Endosomal Transport
Macroautophagy
Cell Differentiation
Protein Catabolic Process
Negative Regulation Of Protein Ubiquitination
Cellular Response To Stress
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Intracellular Signal Transduction
Aggrephagy
Positive Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Regulation Of Protein Complex Stability
Brown Fat Cell Proliferation
Protein K63-linked Ubiquitination
Protein Targeting To Vacuole Involved In Autophagy
Energy Homeostasis
Response To Mitochondrial Depolarisation
Negative Regulation Of Ferroptosis
Membraneless Organelle Assembly
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Macroautophagy
PINK1-PRKN Mediated Mitophagy
TBC/RABGAPs
Receptor Mediated Mitophagy
Pexophagy
Translation of Replicase and Assembly of the Replication Transcription Complex
Translation of Replicase and Assembly of the Replication Transcription Complex
SARS-CoV-2 modulates autophagy
KEAP1-NFE2L2 pathway
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
PINK1-PRKN Mediated Mitophagy
Neddylation
Interleukin-1 signaling
Pexophagy
Signaling by ALK fusions and activated point mutants
KEAP1-NFE2L2 pathway
Nuclear events mediated by NFE2L2
Drugs
Diseases
Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS
General factor of neuroticism (
30867560
)
Major depressive disorder (
22472876
)
Metabolite levels (
23823483
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Alzheimer's disease (late onset) (
24162737
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Interacting Genes
97 interacting genes:
AAMP
ABTB3
ADD1
ADNP
AFTPH
AMBRA1
ANK2
APPL1
ARFGAP1
ATG13
ATG3
ATG4A
ATG4B
ATG4C
ATG4D
ATG7
BAG6
BIRC6
BNIP3
BRD3
BRD9
CAMSAP1
CARS2
CASP8
CCDC50
CCPG1
CCSER2
CDC37
CLTA
CUL3
DBI
DBN1
DNMT3B
DPPA4
EED
EPS8
EVA1A
FLCN
FUNDC1
GORASP2
HYPK
IRGQ
KBTBD7
KLHL5
KXD1
LUC7L2
MESD
MKRN1
MRFAP1
MRTFA
MTX1
MYBL2
NCOR1
NEDD4
NEK9
OPTN
PCNT
PLEKHM1
PRKCZ
PRUNE2
RAD1
RAP1GAP
RASAL3
RETREG1
RETREG2
RIC1
RIPOR1
RPLP1
SAMM50
SEM1
SEPTIN3
SMARCB1
SNCA
SNU13
SNX18
SPAG9
SQSTM1
STK3
STK36
TAF7
TBC1D17
TBC1D25
TBC1D5
TBC1D9
TBC1D9B
THAP7
TMOD3
TNIP1
TPPP
TRIM21
TRIM25
TRIM32
TTN
UPF2
USP10
VHL
WDR90
108 interacting genes:
ACAD10
AIM2
ATXN3
BCL2
BMPR1B
BPTF
BRCA1
CALCR
CALM1
CALR
CAMK2A
CCNF
CDC37
CDC6
CDK1
CRBN
CRYAB
CSNK1A1
DAXX
DAZAP2
DNAI1
DNAI2
DNAJC10
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
HSPA5
IKBKB
IRAK1
KAT5
KCNAB2
KEAP1
KPNA4
LCK
LINC01554
LRRK2
MALT1
MAP1LC3B
MAP2K5
MAPK13
MAPK14
MAPT
MBP
MEIS2
MLH1
MOAP1
MTDH
NBR1
NCOR1
NEDD4
NEDD8
NLRP6
NR2F2
NTRK1
NTRK2
NTRK3
OGT
PADI1
PAWR
PELI1
PIK3CA
PIK3R1
PPHLN1
PRKCD
PRKCI
PRKCZ
RAD23A
RAD54L2
RELN
RIPK1
RNF166
RNF168
RNF26
RPL37
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TGFBR1
TKT
TOE1
TP53INP1
TRAF6
TRIM27
TRIM55
TRIM63
TTN
UBA52
UBB
ULK2
USP8
VANGL2
VAPB
WBP4
WDR81
WEE2-AS1
WWP2
YWHAZ
Entrez ID
81631
8878
HPRD ID
14358
03319
Ensembl ID
ENSG00000140941
ENSG00000161011
Uniprot IDs
Q658J6
Q9GZQ8
Q13501
PDB IDs
1V49
2LUE
2N9X
2ZJD
3VTU
3VTV
3VTW
3WAO
3X0W
4WAA
5D94
5DCN
5GMV
5MS2
5MS5
5MS6
5V4K
5W9A
5XAC
5XAD
5XAE
6J04
6LAN
7ELG
7GA8
7GA9
7GAA
7GAB
7GAC
7GAD
7GAE
7GAF
7GAG
7GAH
7GAI
7GAJ
7GAK
7GAL
7GAM
7GAN
7GAO
7GAP
7GAQ
7GAR
7GAS
7GAU
8Q53
8Q7K
8YV6
1Q02
2JY7
2JY8
2K0B
2KNV
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
6JM4
6KHZ
6MJ7
6TGY
6TH3
7R1O
Enriched GO Terms of Interacting Partners
?
Autophagy
Autophagy Of Mitochondrion
Mitophagy
Macroautophagy
Autophagosome
Autophagosome Assembly
Autophagosome Organization
Nucleophagy
Organelle Organization
Regulation Of Autophagy
Vacuole Organization
Organelle Assembly
Piecemeal Microautophagy Of The Nucleus
Protein-phosphatidylethanolamide Deconjugating Activity
Microautophagy
Catabolic Process
Positive Regulation Of Autophagy
Protein Delipidation
Aggrephagy
Cellular Component Assembly
Establishment Of Protein Localization
Cytoplasm
Substrate Localization To Autophagosome
Intracellular Protein Localization
Protein Transport
Protein Binding
Positive Regulation Of Catabolic Process
Cytosol
Endoplasmic Reticulum-autophagosome Adaptor Activity
Cellular Localization
Establishment Of Localization In Cell
Regulation Of Protein Stability
Proteolysis Involved In Protein Catabolic Process
Cysteine-type Endopeptidase Activity
Regulation Of Cellular Component Organization
Response To Mitochondrial Depolarisation
Proteolysis
Regulation Of Organelle Organization
Regulation Of Macroautophagy
Protein Monoubiquitination
GTPase Activator Activity
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Positive Regulation Of Macroautophagy
Phagophore Assembly Site
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein Catabolic Process
Regulation Of Cell Projection Assembly
Intracellular Signal Transduction
Regulation Of Signal Transduction
Response To Stress
Regulation Of Cell Communication
Regulation Of Signaling
Cytoplasm
Signal Transduction
Positive Regulation Of Metabolic Process
Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Cytosol
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Metabolic Process
Protein Modification Process
Regulation Of Programmed Cell Death
Positive Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Regulation Of Gene Expression
Cellular Response To Stress
Regulation Of Apoptotic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Regulation Of Multicellular Organismal Process
Positive Regulation Of Macromolecule Biosynthetic Process
Response To Growth Factor
Transferase Activity
Intracellular Signaling Cassette
Regulation Of Primary Metabolic Process
Protein Kinase Activity
Protein-containing Complex
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
MAPK Cascade
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Growth Factor Stimulus
Cellular Response To Oxygen-containing Compound
Regulation Of Protein Metabolic Process
Kinase Activity
Modification-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Serine/threonine Kinase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
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Tagcloud (Intersection)
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