SQSTM1 and SMURF1

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		SQSTM1	SMURF1
Description		sequestosome 1	SMAD specific E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Phagophore Assembly Site P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Endosome Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Cytoplasmic Vesicle Intracellular Membraneless Organelle Amphisome Autolysosome Synapse Extracellular Exosome Sperm Midpiece Lewy Body Glutamatergic Synapse	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Axon Neuronal Cell Body Extracellular Exosome
	Molecular Function	Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-modified Protein Reader Activity Protein Sequestering Activity Molecular Sequestering Activity Molecular Condensate Scaffold Activity	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Phospholipid Binding Transferase Activity SMAD Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding Activin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Pexophagy Temperature Homeostasis Immune System Process Response To Ischemia Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus Autophagy Apoptotic Process Endosome Organization Intracellular Protein Localization Positive Regulation Of Autophagy Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Brown Fat Cell Proliferation Protein K63-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Energy Homeostasis Response To Mitochondrial Depolarisation Negative Regulation Of Ferroptosis Membraneless Organelle Assembly Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Export From Nucleus Ectoderm Development Protein Ubiquitination Cell Differentiation BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Receptor Catabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Axon Extension Wnt Signaling Pathway, Planar Cell Polarity Pathway Engulfment Of Target By Autophagosome Substrate Localization To Autophagosome Protein Targeting To Vacuole Involved In Autophagy Protein Localization To Plasma Membrane Positive Regulation Of Dendrite Extension Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Neddylation Interleukin-1 signaling Pexophagy Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2	Signaling by BMP Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Asymmetric localization of PCP proteins Hedgehog 'on' state Hedgehog 'on' state Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Alzheimer's disease (late onset) ( 24162737) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 23128233 28067908) Lack of premeditation ( 30718321) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Ulcerative colitis ( 20228798 28067908)
Interacting Genes		108 interacting genes: ACAD10 AIM2 ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CALR CAMK2A CCNF CDC37 CDC6 CDK1 CRBN CRYAB CSNK1A1 DAXX DAZAP2 DNAI1 DNAI2 DNAJC10 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPA5 IKBKB IRAK1 KAT5 KCNAB2 KEAP1 KPNA4 LCK LINC01554 LRRK2 MALT1 MAP1LC3B MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MOAP1 MTDH NBR1 NCOR1 NEDD4 NEDD8 NLRP6 NR2F2 NTRK1 NTRK2 NTRK3 OGT PADI1 PAWR PELI1 PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RNF26 RPL37 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIM27 TRIM55 TRIM63 TTN UBA52 UBB ULK2 USP8 VANGL2 VAPB WBP4 WDR81 WEE2-AS1 WWP2 YWHAZ	188 interacting genes: ADRM1 ANAPC5 ANKRD13A ANKRD13D ANKRD50 ANKS4B ANXA6 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASCC2 ASH2L ATXN3 AVEN AXIN1 BMPR2 BTK BTRC C9orf78 CALCOCO1 CCDC69 CCM2 CDC40 CDK14 CDKL1 CSNK1D CSNK2A2 CTNNB1 CTNND1 CTTN CUEDC1 CUL5 CXXC1 DDX54 DNAJC7 DUSP13B DVL2 ECSIT ELOF1 ELP3 ENTR1 EPHA1 EPN1 ETV6 FAF2 FBXL15 FBXO3 FBXO30 FCHO1 FES FGF12 FGR FKBP3 FSCN1 FZR1 GNG11 GRIPAP1 GRK3 HDGFL3 HIP1 HOMER2 ILRUN IMPACT ING2 INPP5B IRAK2 ITGB1BP1 ITK JUNB KRT36 LATS1 LCK LHX9 LIMS1 LMNA LONRF3 MAP3K10 MAP3K2 MAP3K3 MAP3K9 MAP4K5 MARK2 MATK MINDY3 MSN NAA16 NDFIP2 NEDD8 NEK2 ODF2 OTUD6B OXSR1 PADI4 PAK1 PAK1IP1 PDGFRA PDLIM7 PICALM PIP5K1C PLEKHO1 POLR2A PRKCA PRKCG PRKCI PRR16 PSMD4 PSME3 PTEN PWP1 RABEP1 RAD23A RASD2 RBCK1 RHOA RHOB RHPN2 RIOK3 RIPK2 RIT1 RNF11 RNF114 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SCYL1 SENP8 SF3A1 SKIC8 SLAIN2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SQSTM1 SRSF4 SRSF5 STK31 STK35 STRAP STUB1 TAB1 TAOK3 TAPT1 TBK1 TLN1 TNIK TNIP2 TNK2 TNNT1 TOM1 TOM1L2 TRAF4 TRIP10 TTC17 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2K UBE2L3 UBE2M UBE2V1 UBQLN1 UBQLN2 UBTF UBXN1 UBXN6 UBXN7 USP45 USP9X WEE1 WFS1 XPO1 ZFAND5
Entrez ID		8878	57154
HPRD ID		03319	06902
Ensembl ID		ENSG00000161011	ENSG00000198742
Uniprot IDs		Q13501	Q9HCE7
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6JM4 6KHZ 6MJ7 6TGY 6TH3 7R1O	2LAZ 2LB0 2LB1 2LTX 3PYC
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Signal Transduction Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Cellular Response To Stress Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Growth Factor Transferase Activity Intracellular Signaling Cassette Regulation Of Primary Metabolic Process Protein Kinase Activity Protein-containing Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen-containing Compound Regulation Of Protein Metabolic Process Kinase Activity Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication	Cytosol Protein Kinase Activity Modification-dependent Protein Catabolic Process Protein Modification Process Cytoplasm Proteolysis Involved In Protein Catabolic Process Kinase Activity Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Intracellular Signaling Cassette Macromolecule Catabolic Process Protein Serine Kinase Activity Proteolysis Post-translational Protein Modification Proteasomal Protein Catabolic Process ATP Binding Nucleus Regulation Of Proteasomal Protein Catabolic Process I-SMAD Binding Nucleotide Binding Macromolecule Metabolic Process Signal Transduction Regulation Of Proteolysis Protein Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Nucleoplasm Protein Modification By Small Protein Conjugation Protein Phosphorylation Heteromeric SMAD Protein Complex Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Ubiquitin Binding Regulation Of Cell Communication Protein Polyubiquitination Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Protein Ubiquitination Polyubiquitin Modification-dependent Protein Binding
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