SQSTM1 and WDR81

Number of citations of the paper that reports this interaction (PubMedID 28404643)
46

Data Source:
BioGRID (imaging technique, pull down)

		SQSTM1	WDR81
Description		sequestosome 1	WD repeat domain 81
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Endosome Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Cytoplasmic Vesicle Intracellular Membraneless Organelle Amphisome Autolysosome Synapse Extracellular Exosome Sperm Midpiece Lewy Body Glutamatergic Synapse	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane
	Molecular Function	Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-modified Protein Reader Activity Protein Sequestering Activity Molecular Sequestering Activity Molecular Condensate Scaffold Activity	Protein Binding Phosphatidylinositol 3-kinase Regulator Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Pexophagy Temperature Homeostasis Immune System Process Response To Ischemia Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus Autophagy Apoptotic Process Endosome Organization Intracellular Protein Localization Positive Regulation Of Autophagy Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Brown Fat Cell Proliferation Protein K63-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Energy Homeostasis Response To Mitochondrial Depolarisation Negative Regulation Of Ferroptosis Membraneless Organelle Assembly Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm	Ubiquitin-dependent Protein Catabolic Process Mitochondrion Organization Aggrephagy Early Endosome To Late Endosome Transport Protein Stabilization
Pathways		NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Neddylation Interleukin-1 signaling Pexophagy Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2	CDC42 GTPase cycle
Drugs
Diseases		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Alzheimer's disease (late onset) ( 24162737) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Apolipoprotein B levels ( 32203549) Calcium levels ( 20705733 24068962) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum albumin levels ( 23022100) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549) Urinary albumin-to-creatinine ratio ( 31630189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		108 interacting genes: ACAD10 AIM2 ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CALR CAMK2A CCNF CDC37 CDC6 CDK1 CRBN CRYAB CSNK1A1 DAXX DAZAP2 DNAI1 DNAI2 DNAJC10 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPA5 IKBKB IRAK1 KAT5 KCNAB2 KEAP1 KPNA4 LCK LINC01554 LRRK2 MALT1 MAP1LC3B MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MOAP1 MTDH NBR1 NCOR1 NEDD4 NEDD8 NLRP6 NR2F2 NTRK1 NTRK2 NTRK3 OGT PADI1 PAWR PELI1 PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RNF26 RPL37 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIM27 TRIM55 TRIM63 TTN UBA52 UBB ULK2 USP8 VANGL2 VAPB WBP4 WDR81 WEE2-AS1 WWP2 YWHAZ	2 interacting genes: MAP1LC3C SQSTM1
Entrez ID		8878	124997
HPRD ID		03319	08748
Ensembl ID		ENSG00000161011	ENSG00000167716
Uniprot IDs		Q13501	Q24JR4 Q562E7
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6JM4 6KHZ 6MJ7 6TGY 6TH3 7R1O
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Signal Transduction Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Cellular Response To Stress Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Growth Factor Transferase Activity Intracellular Signaling Cassette Regulation Of Primary Metabolic Process Protein Kinase Activity Protein-containing Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen-containing Compound Regulation Of Protein Metabolic Process Kinase Activity Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication	Aggrephagy Mitophagy Autophagosome Autophagy Of Mitochondrion Macroautophagy Autophagy Brown Fat Cell Proliferation Amphisome Ubiquitin Protein Ligase Binding Lewy Body Response To Mitochondrial Depolarisation Fat Cell Proliferation Protein Localization To Perinuclear Region Of Cytoplasm Intracellular Membraneless Organelle Intracellular Protein Transport Ubiquitin-modified Protein Reader Activity Cellular Response To Nitrogen Starvation Regulation Of Protein Complex Stability Negative Regulation Of Ferroptosis Protein Targeting To Vacuole Involved In Autophagy Autolysosome Molecular Sequestering Activity Regulation Of Ferroptosis Pexophagy Organelle Assembly Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylethanolamine Binding Inclusion Body Cytoplasmic Vesicle Positive Regulation Of Long-term Synaptic Potentiation K63-linked Polyubiquitin Modification-dependent Protein Binding Phagophore Assembly Site Ionotropic Glutamate Receptor Binding Protein Exit From Endoplasmic Reticulum Regulation Of Toll-like Receptor 4 Signaling Pathway Protein Transport Aggresome Temperature Homeostasis Regulation Of Long-term Synaptic Potentiation Cell Surface Toll-like Receptor Signaling Pathway SH2 Domain Binding Establishment Of Protein Localization Protein Kinase C Binding Sperm Midpiece Regulation Of Ras Protein Signal Transduction Toll-like Receptor 4 Signaling Pathway Molecular Condensate Scaffold Activity Intracellular Transport Protein Sequestering Activity Organelle Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?