MAP1LC3B and DNMT3B

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MAP1LC3B	DNMT3B
Gene Name		microtubule-associated protein 1 light chain 3 beta	DNA (cytosine-5-)-methyltransferase 3 beta
Image
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Autophagic Vacuole Membrane Intracellular Autophagic Vacuole Cytosol Microtubule Axoneme Endomembrane System Extrinsic Component Of Membrane Organelle Membrane Cytoplasmic Vesicle	Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Microtubule Binding GABA Receptor Binding	Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Cellular Response To Nitrogen Starvation Nucleophagy Membrane Fusion	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Response To Ionizing Radiation DNA Methylation On Cytosine Within A CG Sequence Gene Expression Positive Regulation Of Gene Expression Protein Complex Localization DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Response To Drug Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine
Pathways			NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		50 interactors: AAMP ADD1 ADNP ARFGAP1 ATG3 ATG4A ATG4B ATG7 BNIP3 BRD3 CASP8 CCSER2 CLTA DBI DBN1 DNMT3B EED EPS8 FAM134A FAM65A FUNDC1 FYCO1 GABARAPL2 GORASP2 KBTBD7 KLHL5 KXD1 LUC7L2 MKRN1 MRFAP1 MYBL2 NHP2L1 RAD1 RAP1GAP RPLP1 SAFB SHFM1 SMARCB1 SPAG9 SQSTM1 TAF7 TAX1BP1 TBC1D17 TBC1D25 TBC1D9 TBC1D9B THAP7 TMOD3 TNIP1 UPF2	35 interactors: BAZ2A CBX1 CBX3 CBX5 CMTM6 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS ZBTB18
Entrez ID		81631	1789
HPRD ID		14358	04209
Ensembl ID		ENSG00000140941	ENSG00000088305
Uniprot IDs		H6UMI0 Q658J6 Q9GZQ8	Q9UBC3
PDB IDs		1V49 2LUE 2ZJD 3VTU 3VTV 3VTW	3FLG 3QKJ
Enriched GO Terms of Interacting Partners?		Autophagy Mitochondrion Degradation Organelle Disassembly Nucleophagy Cellular Response To Nitrogen Starvation Macroautophagy Regulation Of Organelle Organization Cellular Response To Starvation Positive Regulation Of Metabolic Process Organelle Organization Positive Regulation Of Autophagy Response To Starvation Cellular Response To Nutrient Levels Autophagic Vacuole Assembly Cellular Response To Extracellular Stimulus Cellular Response To Stress Intracellular Transport Catabolic Process Mitochondrion Organization Regulation Of Cellular Component Organization C-terminal Protein Lipidation Protein Delipidation Membrane Organization Response To Stress Vacuole Organization Regulation Of Autophagy Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Complex Disassembly Establishment Of Localization In Cell Regulation Of Histone Modification Actin Filament Capping Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Localization Negative Regulation Of Actin Filament Depolymerization Response To Nutrient Levels Cellular Component Assembly Protein Localization Regulation Of Ras Protein Signal Transduction Response To Extracellular Stimulus Response To Cobalt Ion Protein Targeting To Membrane Regulation Of Actin Filament Depolymerization Organelle Assembly Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Macroautophagy Negative Regulation Of Histone Acetylation	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process DNA Modification Chromatin Modification Chromosome Organization Chromatin Silencing Chromatin Organization Gene Silencing Nucleobase-containing Compound Metabolic Process DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Methylation Transcription, DNA-templated Histone H3-K9 Modification Chromatin Remodeling RNA Metabolic Process DNA Methylation On Cytosine Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Histone Modification Peptidyl-lysine Modification Histone H4 Deacetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Rhythmic Process DNA Packaging Regulation Of Gene Expression By Genetic Imprinting Hypermethylation Of CpG Island C-5 Methylation Of Cytosine
Tagcloud ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Difference) ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Intersection) ?