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SQSTM1 and SNCA
Number of citations of the paper that reports this interaction (PubMedID
11447312
)
0
Data Source:
HPRD
(in vivo)
SQSTM1
SNCA
Description
sequestosome 1
synuclein alpha
Image
GO Annotations
Cellular Component
Phagophore Assembly Site
P-body
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Lysosome
Endosome
Late Endosome
Autophagosome
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Sarcomere
Cytoplasmic Vesicle
Intracellular Membraneless Organelle
Amphisome
Autolysosome
Synapse
Extracellular Exosome
Sperm Midpiece
Lewy Body
Glutamatergic Synapse
Extracellular Region
Extracellular Space
Nucleus
Nuclear Outer Membrane
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Lysosome
Cytosol
Ribosome
Cytoskeleton
Plasma Membrane
Cell Cortex
Synaptic Vesicle
Actin Cytoskeleton
Membrane
Inclusion Body
Axon
Growth Cone
Cytoplasmic Vesicle Membrane
Synaptic Vesicle Membrane
Platelet Alpha Granule Membrane
Protein-containing Complex
Cell Projection
Neuronal Cell Body
Terminal Bouton
Axon Terminus
Synapse
Perinuclear Region Of Cytoplasm
Presynapse
Postsynapse
Supramolecular Fiber
Molecular Function
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Ionotropic Glutamate Receptor Binding
Signaling Receptor Activity
SH2 Domain Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Ubiquitin-modified Protein Reader Activity
Protein Sequestering Activity
Molecular Sequestering Activity
Molecular Condensate Scaffold Activity
SNARE Binding
Magnesium Ion Binding
Transcription Cis-regulatory Region Binding
Actin Binding
Enzyme Inhibitor Activity
Protein Kinase Inhibitor Activity
Cysteine-type Endopeptidase Inhibitor Activity
Fatty Acid Binding
Copper Ion Binding
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Microtubule Binding
Enzyme Activator Activity
Ferrous Iron Binding
Zinc Ion Binding
Lipid Binding
Oxidoreductase Activity
Kinesin Binding
Enzyme Binding
Protein Domain Specific Binding
Hsp70 Protein Binding
Histone Binding
Identical Protein Binding
Alpha-tubulin Binding
Phospholipase Binding
Metal Ion Binding
Tau Protein Binding
Beta-tubulin Binding
Phosphoprotein Binding
Molecular Adaptor Activity
Phospholipase D Inhibitor Activity
Dynein Complex Binding
Protein Sequestering Activity
Transporter Regulator Activity
Cuprous Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Autophagy Of Mitochondrion
Mitophagy
Pexophagy
Temperature Homeostasis
Immune System Process
Response To Ischemia
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Import Into Nucleus
Autophagy
Apoptotic Process
Endosome Organization
Intracellular Protein Localization
Positive Regulation Of Autophagy
Regulation Of Mitochondrion Organization
Endosomal Transport
Macroautophagy
Cell Differentiation
Protein Catabolic Process
Negative Regulation Of Protein Ubiquitination
Cellular Response To Stress
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Intracellular Signal Transduction
Aggrephagy
Positive Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Regulation Of Protein Complex Stability
Brown Fat Cell Proliferation
Protein K63-linked Ubiquitination
Protein Targeting To Vacuole Involved In Autophagy
Energy Homeostasis
Response To Mitochondrial Depolarisation
Negative Regulation Of Ferroptosis
Membraneless Organelle Assembly
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Protein Localization To Perinuclear Region Of Cytoplasm
Negative Regulation Of Transcription By RNA Polymerase II
Microglial Cell Activation
Positive Regulation Of Receptor Recycling
Positive Regulation Of Neurotransmitter Secretion
Synaptic Transmission, Dopaminergic
Fatty Acid Metabolic Process
Neutral Lipid Metabolic Process
Phospholipid Metabolic Process
Glutathione Metabolic Process
Mitochondrial Membrane Organization
Chemical Synaptic Transmission
Neurotransmitter Secretion
Adult Locomotory Behavior
Response To Xenobiotic Stimulus
Response To Iron(II) Ion
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Glutamate Secretion
Regulation Of Dopamine Secretion
Synaptic Vesicle Exocytosis
Synaptic Vesicle Priming
Negative Regulation Of Microtubule Polymerization
Receptor Internalization
Protein Destabilization
Response To Magnesium Ion
Response To Lipopolysaccharide
Response To Type II Interferon
Cellular Response To Oxidative Stress
SNARE Complex Assembly
Positive Regulation Of SNARE Complex Assembly
Regulation Of Locomotion
Response To Cocaine
Dopamine Biosynthetic Process
Dopamine Metabolic Process
Mitochondrial ATP Synthesis Coupled Electron Transport
Regulation Of Macrophage Activation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Endocytosis
Negative Regulation Of Exocytosis
Positive Regulation Of Exocytosis
Negative Regulation Of Dopamine Metabolic Process
Regulation Of Neurotransmitter Secretion
Behavioral Response To Cocaine
Regulation Of Neuronal Synaptic Plasticity
Regulation Of Long-term Neuronal Synaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Transport
Positive Regulation Of Inflammatory Response
Positive Regulation Of Synaptic Transmission
Synapse Organization
Regulation Of Acyl-CoA Biosynthetic Process
Protein Complex Oligomerization
Protein Tetramerization
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Serotonin Uptake
Regulation Of Norepinephrine Uptake
Negative Regulation Of Norepinephrine Uptake
Calcium Ion Homeostasis
Excitatory Postsynaptic Potential
Long-term Synaptic Potentiation
Positive Regulation Of Inositol Phosphate Biosynthetic Process
Membrane Organization
Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
Regulation Of Microtubule Cytoskeleton Organization
Response To Interleukin-1
Cellular Response To Copper Ion
Cellular Response To Epinephrine Stimulus
Supramolecular Fiber Organization
Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Positive Regulation Of Hydrogen Peroxide Catabolic Process
Regulation Of Synaptic Vesicle Recycling
Regulation Of Reactive Oxygen Species Biosynthetic Process
Response To Desipramine
Positive Regulation Of Protein Localization To Cell Periphery
Negative Regulation Of Chaperone-mediated Autophagy
Regulation Of Presynapse Assembly
Amyloid Fibril Formation
Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
PINK1-PRKN Mediated Mitophagy
Neddylation
Interleukin-1 signaling
Pexophagy
Signaling by ALK fusions and activated point mutants
KEAP1-NFE2L2 pathway
Nuclear events mediated by NFE2L2
Amyloid fiber formation
PKR-mediated signaling
Drugs
Resveratrol
Dequalinium
Copper
Diseases
Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
Parkinson's disease (PD)
GWAS
Alzheimer's disease (late onset) (
24162737
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Anxiety (
33859377
)
Blood protein levels (
30072576
)
Dementia with Lewy bodies (
29263008
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Feeling nervous (
29500382
)
Neurociticism (
29500382
)
Parkinson's disease (
28892059
34064523
32310270
32201043
31660654
19915575
28011712
21084426
19915576
20070850
20711177
21044948
21292315
21738487
22438815
22451204
24511991
25064009
27182965
)
Parkinson's disease (age of onset) (
30957308
31660654
33884653
)
Parkinson's disease in GBA mutation carriers (
31755958
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Response to bupropion in depression (
27622933
)
Interacting Genes
108 interacting genes:
ACAD10
AIM2
ATXN3
BCL2
BMPR1B
BPTF
BRCA1
CALCR
CALM1
CALR
CAMK2A
CCNF
CDC37
CDC6
CDK1
CRBN
CRYAB
CSNK1A1
DAXX
DAZAP2
DNAI1
DNAI2
DNAJC10
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
HSPA5
IKBKB
IRAK1
KAT5
KCNAB2
KEAP1
KPNA4
LCK
LINC01554
LRRK2
MALT1
MAP1LC3B
MAP2K5
MAPK13
MAPK14
MAPT
MBP
MEIS2
MLH1
MOAP1
MTDH
NBR1
NCOR1
NEDD4
NEDD8
NLRP6
NR2F2
NTRK1
NTRK2
NTRK3
OGT
PADI1
PAWR
PELI1
PIK3CA
PIK3R1
PPHLN1
PRKCD
PRKCI
PRKCZ
RAD23A
RAD54L2
RELN
RIPK1
RNF166
RNF168
RNF26
RPL37
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TGFBR1
TKT
TOE1
TP53INP1
TRAF6
TRIM27
TRIM55
TRIM63
TTN
UBA52
UBB
ULK2
USP8
VANGL2
VAPB
WBP4
WDR81
WEE2-AS1
WWP2
YWHAZ
419 interacting genes:
A1BG
ACAP1
ACKR2
ACTA1
ACTR1A
ADAP2
ADM
ADORA2A
ADRB2
AGO2
AKT1
AMBRA1
ANGPT1
ANXA2
ANXA6
AP1G2
AP2M1
APBB1
APLP1
APOC2
APOC3
APOE
APP
ARAP2
ARAP3
ARF1
ARF3
ARF5
ARF6
ARFGAP1
ARFGAP2
ARFGAP3
ARHGAP15
ARPP19
ARRB1
ARRB2
ARSA
ASGR1
ASGR2
ATP13A1
AXIN2
B4GALT1
BAD
BAG5
BASP1
BCL2L1
BCL6
BDH2
BET1
CACFD1
CACNB4
CACNG5
CACYBP
CALM1
CALU
CAMK1D
CAP1
CAV1
CAV2
CAV3
CBLC
CBS
CCL3
CCR1
CDC42
CDC42EP2
CDC42EP3
CDC42SE1
CDH13
CDK4
CHMP1B
CHMP2A
CHMP2B
CHMP4B
CHMP6
CHRM3
CHRM4
CHRM5
CHRNA4
CHRNB2
CHRND
CKB
CLEC10A
CLEC4M
CLSTN2
CLTB
CLTCL1
CNIH2
CNN3
CNST
COL25A1
COLEC11
COLQ
COPG1
CPEB1
CPLX4
CPNE1
CPNE3
CRIPT
CRYAB
CSNK1A1
CSNK1D
CSNK1E
CSNK1G1
CSNK1G2
CSNK1G3
CSNK2A1
CSNK2A2
CTNND1
CTSD
CXCL16
CYCS
CYTH2
CYTH3
CYTH4
DBH
DDX1
DDX17
DLG3
DMTN
DNAJA1
DNAJC5
DNM1
DNM3
DOCK7
DOLPP1
DTNB
DVL1
DYRK1A
EDC4
EEF1D
EGFR
EGR1
EGR3
EHD3
EIF3C
EIF3G
EIF3L
ELK1
ELMO3
ELMOD3
ENC1
ENSA
EPN2
ERBB3
ERGIC2
ERGIC3
EXOC1
F2R
FAM120A
FAM98A
FBXL5
FBXW7
FGFR4
FGR
FOLR3
FSHR
FTH1
FYN
GAB2
GABARAPL1
GABRA4
GAD1
GBA1
GHRH
GNAI1
GNAI3
GRK1
GRK2
GRK3
GRK4
GRK5
GRK6
GULP1
H1-1
H1-2
H2AC11
HFE
HOMER3
HSD17B4
HSPA1B
HSPA6
HSPA8
HSPB2
HSPB6
HSPB8
HTR1B
ICA1
IQSEC2
ITSN2
KAT2A
KAT2B
KCNJ10
KCNMB4
KDR
KIAA1191
KLC1
KLK6
LAMP2
LDLRAP1
LEFTY2
LGALS3
LILRB1
LIN7B
LIN7C
LRFN2
LRP12
LRPAP1
LRRC15
LRRC4
LYN
MAP1B
MAP1LC3B
MAP4K2
MAPK1
MAPK8
MAPK8IP1
MAPKAPK5
MAPT
MARCO
MDM2
MEF2D
MLC1
MME
MMRN1
MS4A2
MSR1
MT-CO1
MT-CO3
MVB12A
MYH9
MYLK2
MYO6
NAP1L1
NECAP1
NECAP2
NEDD4
NEDD4L
NKD2
NME1
NRP1
OPTN
OSBPL11
OSBPL5
OSBPL7
PABPC1
PACSIN1
PAICS
PAK3
PARD6A
PARK7
PATL1
PCLO
PDCD6IP
PDE4DIP
PDIA2
PDLIM7
PELP1
PF4
PHACTR1
PHETA1
PIAS3
PIK3CD
PIP5K1B
PIP5K1C
PLAT
PLCB2
PLD1
PLG
PLK1
PLK3
PLS3
PML
POPDC1
PPP3CA
PRDX1
PREP
PRKAR1A
PRKCE
PRKN
PSD3
PSMA1
PSMB1
PTBP1
PTK2B
PTPN18
PTPN6
PTPRR
PTX3
QARS1
RAB11A
RAB11B
RAB11FIP1
RAB11FIP2
RAB17
RAB1A
RAB20
RAB26
RAB3A
RAB4A
RAB5A
RAB5B
RAB5C
RABAC1
RABEP1
RAC1
RALA
RASGRP2
RBBP4
RET
RHOA
RHOBTB3
RNF10
ROPN1B
RPH3AL
RPL18A
RPL22
RPS12
RPS25
RUFY1
S100A9
SAMD4A
SAP30BP
SCAMP1
SCARA5
SCYL1
SDF4
SELE
SEMA4F
SEPTIN2
SEPTIN3
SEPTIN4
SFRP4
SH3BP4
SIAH2
SLC22A2
SLC30A8
SLC35E2B
SLC5A7
SLC6A1
SLC6A15
SLC6A20
SLC6A3
SLC6A7
SMAP2
SMURF2
SNCAIP
SNCB
SNX1
SNX16
SPAG9
SPTBN1
SQSTM1
SRC
SRI
ST13
STAM
STAMBP
STUB1
STX11
STX18
STX1B
STX2
STXBP3
SYK
SYN1
SYN3
SYPL2
SYT3
SYTL4
TFG
TFRC
TGFB2
TGM1
TGM2
TH
TOM1
TOMM20
TOR1A
TPPP
TPRG1L
TRAPPC2
TRAPPC6B
TRIP11
TRPV6
TSG101
TUBA1A
TXLNA
UBA52
UBB
UBC
UBE2D2
UBE2W
UBL3
USP2
USP33
USP47
USP7
USP8
VAMP2
VCP
VPS13C
VPS25
VPS28
VPS29
VPS36
VPS37D
VPS45
VPS4A
VTA1
WASHC2A
WTAP
YOD1
YTHDF1
YTHDF2
YWHAB
YWHAE
YWHAH
ZRANB1
Entrez ID
8878
6622
HPRD ID
03319
01227
Ensembl ID
ENSG00000161011
ENSG00000145335
Uniprot IDs
Q13501
H6UYS5
P37840
PDB IDs
1Q02
2JY7
2JY8
2K0B
2KNV
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
6JM4
6KHZ
6MJ7
6TGY
6TH3
7R1O
1XQ8
2JN5
2KKW
2M55
2N0A
2X6M
3Q25
3Q26
3Q27
3Q28
3Q29
4BXL
4R0U
4R0W
4RIK
4RIL
4ZNN
5CRW
6A6B
6CT7
6CU7
6CU8
6H6B
6I42
6L1T
6L1U
6L4S
6LRQ
6OSJ
6OSL
6OSM
6PEO
6PES
6RT0
6RTB
6SST
6SSX
6UFR
6XYO
6XYP
6XYQ
7C1D
7E0F
7L7H
7LC9
7NCA
7NCG
7NCH
7NCI
7NCJ
7NCK
7OZG
7OZH
7STX
7UAK
7V47
7V48
7V49
7V4A
7V4B
7V4C
7V4D
7WMM
7WNZ
7WO0
7XJX
7XO0
7XO1
7XO2
7XO3
7YK2
7YK8
7YNF
7YNG
7YNL
7YNM
7YNN
7YNO
7YNP
7YNQ
7YNR
7YNS
7YNT
8A4L
8A9L
8ADS
8ADU
8ADV
8ADW
8AEX
8B9V
8BQV
8BQW
8CE7
8CEB
8CYR
8CYS
8CYT
8CYV
8CYW
8CYX
8CYY
8CZ0
8CZ1
8CZ2
8CZ3
8CZ6
8FPT
8G0L
8GF7
8H03
8H04
8H05
8HZB
8HZC
8HZS
8JEX
8JEY
8JJV
8JLY
8OG0
8OJR
8OL8
8OQI
8PIX
8PJO
8PK2
8PK4
8QPZ
8RI9
8RQM
8RRR
8UKA
8X7B
8X7L
8X7M
8X7O
8X7P
8X7Q
8X7R
8XWD
8Y2P
8Y2Q
8ZLI
8ZLO
8ZLP
8ZMY
8ZWH
8ZWI
8ZWJ
8ZWK
9CD9
9CDA
9CK3
9CX6
9D5C
9EUU
9FYP
9HGR
9HGS
9HXA
9IJP
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Regulation Of Signal Transduction
Response To Stress
Regulation Of Cell Communication
Regulation Of Signaling
Cytoplasm
Signal Transduction
Positive Regulation Of Metabolic Process
Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Cytosol
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Metabolic Process
Protein Modification Process
Regulation Of Programmed Cell Death
Positive Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Regulation Of Gene Expression
Cellular Response To Stress
Regulation Of Apoptotic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Regulation Of Multicellular Organismal Process
Positive Regulation Of Macromolecule Biosynthetic Process
Response To Growth Factor
Transferase Activity
Intracellular Signaling Cassette
Regulation Of Primary Metabolic Process
Protein Kinase Activity
Protein-containing Complex
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
MAPK Cascade
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Growth Factor Stimulus
Cellular Response To Oxygen-containing Compound
Regulation Of Protein Metabolic Process
Kinase Activity
Modification-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Serine/threonine Kinase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Vesicle-mediated Transport
Endocytosis
Import Into Cell
Regulation Of Vesicle-mediated Transport
Regulation Of Transport
Plasma Membrane
Intracellular Protein Localization
Protein Transport
Regulation Of Signaling
Cytoplasm
Establishment Of Protein Localization
Regulation Of Cell Communication
Establishment Of Localization In Cell
Regulation Of Cellular Component Organization
Synapse
Endosome
Membrane
Regulation Of Endocytosis
Cytosol
Cellular Localization
Vesicle Organization
Extracellular Exosome
Regulation Of Protein Localization
Receptor-mediated Endocytosis
Regulation Of Biological Quality
Regulation Of Signal Transduction
Regulation Of Secretion
Intracellular Transport
Regulation Of Secretion By Cell
Positive Regulation Of Transport
Membrane Organization
Secretion
Cytoplasmic Vesicle
Exocytosis
Multivesicular Body Assembly
Secretion By Cell
Positive Regulation Of Cellular Component Organization
Multivesicular Body Organization
Early Endosome
Endosome Organization
Presynapse
Modulation Of Chemical Synaptic Transmission
Intracellular Protein Transport
Ubiquitin Protein Ligase Binding
Endosomal Transport
Positive Regulation Of Catabolic Process
Organelle Localization
Glutamatergic Synapse
Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Localization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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