SQSTM1 and GRIA3

Number of citations of the paper that reports this interaction (PMID 19004011)
7

Data Source:
HPRD (in vitro, in vivo)

		SQSTM1	GRIA3
Gene Name		sequestosome 1	glutamate receptor, ionotropic, AMPA 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Lysosome Late Endosome Autophagic Vacuole Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Cytoplasmic Vesicle Extracellular Vesicular Exosome	Plasma Membrane Cell Junction Dendrite Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Postsynaptic Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding K63-linked Polyubiquitin Binding	Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Immune System Process Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Protein Localization Endosomal Transport Macroautophagy Positive Regulation Of Macroautophagy Cell Differentiation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Protein Heterooligomerization Apoptotic Signaling Pathway	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic
Pathways		Signaling by Interleukins Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes Cell death signalling via NRAGE, NRIF and NADE NRIF signals cell death from the nucleus p75NTR signals via NF-kB Cytokine Signaling in Immune system Interleukin-1 signaling p75 NTR receptor-mediated signalling	Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Lithium Aniracetam
Diseases
GWAS
Protein-Protein Interactions		74 interactors: ATXN3 BCL2 BMPR1B BPTF CALM1 CAMK2A CCNB1 CDC37 CDK1 CSNK2A1 DAZAP2 EEF1D EGLN3 FKBP4 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 IRAK1 KCNAB2 KEAP1 LCK LINC00341 MALT1 MAP1LC3A MAP1LC3B MAP2K5 MAP3K3 MAPK14 MBP MEIS2 MLH1 NBR1 NCOR1 NR2F2 NTRK1 NTRK2 NTRK3 OPTN PAWR PIK3CA PPHLN1 PRKCI PRKCZ RAD23A RELN RIPK1 RPL37 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53 TRAF6 TRIM55 TRIM63 TTN UBA52 UBB UBC ULK1 ULK2 YWHAZ	11 interactors: ADRB2 GRIA2 GRIP1 GRIP2 GZMB LYN NSF PICK1 PPM1G SDCBP SQSTM1
Entrez ID		8878	2892
HPRD ID		03319	02378
Ensembl ID		ENSG00000161011	ENSG00000125675
Uniprot IDs		Q13501	P42263 Q17R51 Q5XKG2
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV
Enriched GO Terms of Interacting Partners?		Cell Communication Response To Growth Factor Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Phosphorylation Cellular Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Positive Regulation Of Kinase Activity Regulation Of Cell Death Negative Regulation Of Cell Death Response To Organic Substance Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Protein Phosphorylation Activation Of Protein Kinase Activity Membrane Organization Neurotrophin TRK Receptor Signaling Pathway Cellular Component Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cellular Response To Stress	Cell-cell Signaling Synaptic Transmission Signaling Cell Communication Regulation Of Vesicle-mediated Transport Intracellular Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Exocytosis Response To Extracellular Stimulus Protein Localization Cellular Response To Extracellular Stimulus Establishment Of Localization In Cell Regulation Of Signaling Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Cellular Localization Positive Regulation Of Phosphorylation Apoptotic Signaling Pathway Signal Transduction Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Enzyme Linked Receptor Protein Signaling Pathway Protein Localization To Membrane Neuron Development Response To External Stimulus Response To Nutrient Levels Regulation Of Cellular Localization Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Golgi Vesicle Docking Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Glial Cell Development Neuron Differentiation Cell Projection Organization Tolerance Induction To Self Antigen Fc Receptor Mediated Inhibitory Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Extracellular Vesicular Exosome Assembly Cellular Response To Starvation Positive Regulation Of Signal Transduction Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Granzyme-mediated Apoptotic Signaling Pathway
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Intersection) ?