SQSTM1 and MEIS2

Number of citations of the paper that reports this interaction (PMID 14702098)
7

Data Source:
BioGRID (pull down)

		SQSTM1	MEIS2
Gene Name		sequestosome 1	Meis homeobox 2
Image
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Lysosome Late Endosome Autophagic Vacuole Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Cytoplasmic Vesicle Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding K63-linked Polyubiquitin Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Immune System Process Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Protein Localization Endosomal Transport Macroautophagy Positive Regulation Of Macroautophagy Cell Differentiation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Protein Heterooligomerization Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Eye Development Transcription From RNA Polymerase II Promoter Response To Mechanical Stimulus Pancreas Development Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor
Pathways		Signaling by Interleukins Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes Cell death signalling via NRAGE, NRIF and NADE NRIF signals cell death from the nucleus p75NTR signals via NF-kB Cytokine Signaling in Immune system Interleukin-1 signaling p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS			Hyperactive-impulsive symptoms ( 18821565) Response to antipsychotic treatment ( 20195266)
Protein-Protein Interactions		74 interactors: ATXN3 BCL2 BMPR1B BPTF CALM1 CAMK2A CCNB1 CDC37 CDK1 CSNK2A1 DAZAP2 EEF1D EGLN3 FKBP4 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 IRAK1 KCNAB2 KEAP1 LCK LINC00341 MALT1 MAP1LC3A MAP1LC3B MAP2K5 MAP3K3 MAPK14 MBP MEIS2 MLH1 NBR1 NCOR1 NR2F2 NTRK1 NTRK2 NTRK3 OPTN PAWR PIK3CA PPHLN1 PRKCI PRKCZ RAD23A RELN RIPK1 RPL37 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53 TRAF6 TRIM55 TRIM63 TTN UBA52 UBB UBC ULK1 ULK2 YWHAZ	14 interactors: ANXA1 APP ARNT2 C1orf94 CRBN DGCR6 HOXA13 HOXA9 LINC00238 OSGIN1 PBX1 SQSTM1 TRIM25 ZNHIT3
Entrez ID		8878	4212
HPRD ID		03319	03443
Ensembl ID		ENSG00000161011	ENSG00000134138
Uniprot IDs		Q13501	B3KPD8 B7Z6F6 O14770
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV	3K2A
Enriched GO Terms of Interacting Partners?		Cell Communication Response To Growth Factor Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Phosphorylation Cellular Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Positive Regulation Of Kinase Activity Regulation Of Cell Death Negative Regulation Of Cell Death Response To Organic Substance Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Protein Phosphorylation Activation Of Protein Kinase Activity Membrane Organization Neurotrophin TRK Receptor Signaling Pathway Cellular Component Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cellular Response To Stress	Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Embryonic Limb Morphogenesis Regulation Of Cell Cycle Process Gland Development Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Limb Development Response To Estrogen Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Death Regulation Of G2/M Transition Of Mitotic Cell Cycle Developmental Process Regulation Of Cell Cycle G2/M Phase Transition Proximal/distal Pattern Formation Organ Development Regulation Of Transcription, DNA-templated Embryonic Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Reproductive Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Immune System Process Developmental Process Involved In Reproduction Regulation Of RNA Metabolic Process Forelimb Morphogenesis Sex Differentiation Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Neutrophil Clearance Prostate Gland Development Multicellular Organismal Development Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Urogenital System Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Neutrophil Apoptotic Process Synaptic Growth At Neuromuscular Junction
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1	accumulative aldehyde aldh1a1 blots cbfb cxcl6 devastating diras diras3 feel glaucoma homeobox identifiable immunocytochemistry meshwork negatives pitx2 protocols pursued ranking samd5 sirnas statistic sterile subtle tm tms vis
Tagcloud (Difference) ?		anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1	accumulative aldehyde blots cbfb cxcl6 devastating diras diras3 feel glaucoma homeobox identifiable immunocytochemistry meshwork negatives pitx2 protocols pursued ranking samd5 sirnas statistic sterile subtle tm tms vis
Tagcloud (Intersection) ?		aldh1a1