MAP1LC3B and BIRC6

Number of citations of the paper that reports this interaction (PubMedID 33545068)
0

Data Source:
BioGRID (proximity labelling technology, enzymatic study, unspecified method)

		MAP1LC3B	BIRC6
Description		microtubule associated protein 1 light chain 3 beta	baculoviral IAP repeat containing 6
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GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Cytosol Cytoskeleton Microtubule Axoneme Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Mitochondrial Membrane	Spindle Pole Nucleus Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Membrane Midbody Flemming Body
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Ceramide Binding	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Transferase Activity Peptidase Inhibitor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Autophagosome Maturation	Placenta Development Protein Phosphorylation Apoptotic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Regulation Of Cytokinesis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Cell Division Labyrinthine Layer Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Macroautophagy PINK1-PRKN Mediated Mitophagy TBC/RABGAPs Receptor Mediated Mitophagy Pexophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 modulates autophagy KEAP1-NFE2L2 pathway	ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		General factor of neuroticism ( 30867560) Major depressive disorder ( 22472876) Metabolite levels ( 23823483) Neuroticism ( 29255261) Refractive error ( 32231278)	Chronotype ( 30696823) Coffee consumption ( 31046077) General risk tolerance (MTAG) ( 30643258) Male-pattern baldness ( 28196072) Red cell distribution width ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		97 interacting genes: AAMP ABTB3 ADD1 ADNP AFTPH AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 BAG6 BIRC6 BNIP3 BRD3 BRD9 CAMSAP1 CARS2 CASP8 CCDC50 CCPG1 CCSER2 CDC37 CLTA CUL3 DBI DBN1 DNMT3B DPPA4 EED EPS8 EVA1A FLCN FUNDC1 GORASP2 HYPK IRGQ KBTBD7 KLHL5 KXD1 LUC7L2 MESD MKRN1 MRFAP1 MRTFA MTX1 MYBL2 NCOR1 NEDD4 NEK9 OPTN PCNT PLEKHM1 PRKCZ PRUNE2 RAD1 RAP1GAP RASAL3 RETREG1 RETREG2 RIC1 RIPOR1 RPLP1 SAMM50 SEM1 SEPTIN3 SMARCB1 SNCA SNU13 SNX18 SPAG9 SQSTM1 STK3 STK36 TAF7 TBC1D17 TBC1D25 TBC1D5 TBC1D9 TBC1D9B THAP7 TMOD3 TNIP1 TPPP TRIM21 TRIM25 TRIM32 TTN UPF2 USP10 VHL WDR90	29 interacting genes: ARIH1 BIRC2 BIRC5 CASP3 CASP8 CASP9 CDK1 CSNK2A1 DIABLO EXOC3 EXOC4 GABARAP HTRA2 MAP1LC3B MAP2K1 NEDD4 PLK1 RAB8A RACK1 RNF144A RNF4 RNF41 UBA6 UBC UBE2D1 UBE3C USP8 VAV2 VCL
Entrez ID		81631	57448
HPRD ID		14358	05731
Ensembl ID		ENSG00000140941	ENSG00000115760
Uniprot IDs		Q658J6 Q9GZQ8	A0A8V8TQB4 A0A8V8TR92 Q9NR09
PDB IDs		1V49 2LUE 2N9X 2ZJD 3VTU 3VTV 3VTW 3WAO 3X0W 4WAA 5D94 5DCN 5GMV 5MS2 5MS5 5MS6 5V4K 5W9A 5XAC 5XAD 5XAE 6J04 6LAN 7ELG 7GA8 7GA9 7GAA 7GAB 7GAC 7GAD 7GAE 7GAF 7GAG 7GAH 7GAI 7GAJ 7GAK 7GAL 7GAM 7GAN 7GAO 7GAP 7GAQ 7GAR 7GAS 7GAU 8Q53 8Q7K 8YV6	3CEG 8ATM 8ATO 8ATU 8ATX 8AUK 8AUW 8E2D 8E2E 8E2F 8E2G 8E2H 8E2I 8E2K
Enriched GO Terms of Interacting Partners?		Autophagy Autophagy Of Mitochondrion Mitophagy Macroautophagy Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Organelle Organization Regulation Of Autophagy Vacuole Organization Organelle Assembly Piecemeal Microautophagy Of The Nucleus Protein-phosphatidylethanolamide Deconjugating Activity Microautophagy Catabolic Process Positive Regulation Of Autophagy Protein Delipidation Aggrephagy Cellular Component Assembly Establishment Of Protein Localization Cytoplasm Substrate Localization To Autophagosome Intracellular Protein Localization Protein Transport Protein Binding Positive Regulation Of Catabolic Process Cytosol Endoplasmic Reticulum-autophagosome Adaptor Activity Cellular Localization Establishment Of Localization In Cell Regulation Of Protein Stability Proteolysis Involved In Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Cellular Component Organization Response To Mitochondrial Depolarisation Proteolysis Regulation Of Organelle Organization Regulation Of Macroautophagy Protein Monoubiquitination GTPase Activator Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Macroautophagy Phagophore Assembly Site Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Catabolic Process Regulation Of Cell Projection Assembly	Post-translational Protein Modification Protein Ubiquitination Proteolysis Cytosol Protein Modification By Small Protein Conjugation Protein Modification Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Apoptotic Process Catabolic Process Programmed Cell Death Cell Death Midbody Mitotic Cytokinesis Response To Anesthetic Execution Phase Of Apoptosis Ubiquitin Protein Ligase Activity Regulation Of Autophagy Regulation Of Apoptotic Process Modification-dependent Protein Catabolic Process Regulation Of Programmed Cell Death Protein Polyubiquitination Cytoskeleton-dependent Cytokinesis Response To Cobalt Ion CD40 Receptor Complex Regulation Of Macroautophagy Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Signal Transduction Regulation Of Protein Localization Cytoplasm Transferase Activity Regulation Of Protein Catabolic Process Golgi Inheritance Positive Regulation Of Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Protein Metabolic Process Cysteine-type Endopeptidase Activity DNA Damage Response Cellular Response To Stress Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Localization To Site Of Double-strand Break Macromolecule Metabolic Process
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