SQSTM1 and TKT

Number of citations of the paper that reports this interaction (PMID 14702098)
7

Data Source:
BioGRID (pull down)

		SQSTM1	TKT
Gene Name		sequestosome 1	transketolase
Image
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Lysosome Late Endosome Autophagic Vacuole Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Cytoplasmic Vesicle Extracellular Vesicular Exosome	Nucleus Nucleoplasm Peroxisome Cytosol Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding K63-linked Polyubiquitin Binding	Transketolase Activity Protein Homodimerization Activity Metal Ion Binding Cofactor Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Immune System Process Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Protein Localization Endosomal Transport Macroautophagy Positive Regulation Of Macroautophagy Cell Differentiation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Protein Heterooligomerization Apoptotic Signaling Pathway	Carbohydrate Metabolic Process Xylulose Biosynthetic Process Pentose-phosphate Shunt Energy Reserve Metabolic Process Pentose-phosphate Shunt, Non-oxidative Branch Pathogenesis Regulation Of Growth Small Molecule Metabolic Process Glyceraldehyde-3-phosphate Biosynthetic Process
Pathways		Signaling by Interleukins Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes Cell death signalling via NRAGE, NRIF and NADE NRIF signals cell death from the nucleus p75NTR signals via NF-kB Cytokine Signaling in Immune system Interleukin-1 signaling p75 NTR receptor-mediated signalling	Integration of energy metabolism Insulin effects increased synthesis of Xylulose-5-Phosphate Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Pentose phosphate pathway (hexose monophosphate shunt)
Drugs
Diseases
GWAS			Ventricular conduction ( 21076409)
Protein-Protein Interactions		74 interactors: ATXN3 BCL2 BMPR1B BPTF CALM1 CAMK2A CCNB1 CDC37 CDK1 CSNK2A1 DAZAP2 EEF1D EGLN3 FKBP4 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 IRAK1 KCNAB2 KEAP1 LCK LINC00341 MALT1 MAP1LC3A MAP1LC3B MAP2K5 MAP3K3 MAPK14 MBP MEIS2 MLH1 NBR1 NCOR1 NR2F2 NTRK1 NTRK2 NTRK3 OPTN PAWR PIK3CA PPHLN1 PRKCI PRKCZ RAD23A RELN RIPK1 RPL37 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53 TRAF6 TRIM55 TRIM63 TTN UBA52 UBB UBC ULK1 ULK2 YWHAZ	3 interactors: MYOC SQSTM1 TERF1
Entrez ID		8878	7086
HPRD ID		03319	06001
Ensembl ID		ENSG00000161011	ENSG00000163931
Uniprot IDs		Q13501	P29401
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV	3MOS 3OOY 4KXU 4KXV 4KXW 4KXX 4KXY
Enriched GO Terms of Interacting Partners?		Cell Communication Response To Growth Factor Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Phosphorylation Cellular Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Positive Regulation Of Kinase Activity Regulation Of Cell Death Negative Regulation Of Cell Death Response To Organic Substance Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Protein Phosphorylation Activation Of Protein Kinase Activity Membrane Organization Neurotrophin TRK Receptor Signaling Pathway Cellular Component Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cellular Response To Stress	ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Positive Regulation Of Cytoskeleton Organization ERBB2 Signaling Pathway Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Positive Regulation Of Cellular Component Biogenesis Non-canonical Wnt Signaling Pathway Via JNK Cascade Negative Regulation Of Telomere Maintenance Via Telomerase Non-canonical Wnt Signaling Pathway Via MAPK Cascade Positive Regulation Of Organelle Organization Clustering Of Voltage-gated Sodium Channels Protein Oligomerization Replicative Cell Aging Skeletal Muscle Adaptation Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytoskeleton Organization Neuronal Ion Channel Clustering Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Microtubule Polymerization Positive Regulation Of Apoptotic Process Positive Regulation Of Macroautophagy Regulation Of Telomerase Activity Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Mitochondrial Depolarization Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Hypertrophy Regulation Of Microtubule Polymerization Neuron Maturation Telomere Maintenance Via Telomere Lengthening Non-canonical Wnt Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 topbp1 znf668
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 topbp1 znf668
Tagcloud (Intersection) ?