SQSTM1 and RELN

Number of citations of the paper that reports this interaction (PubMedID 14702098)
46

Data Source:
BioGRID (pull down)

		SQSTM1	RELN
Description		sequestosome 1	reelin
Image
GO Annotations	Cellular Component	Phagophore Assembly Site P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Endosome Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Cytoplasmic Vesicle Intracellular Membraneless Organelle Amphisome Autolysosome Synapse Extracellular Exosome Sperm Midpiece Lewy Body Glutamatergic Synapse	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Dendrite Extracellular Matrix Neuron Projection Reelin Complex
	Molecular Function	Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-modified Protein Reader Activity Protein Sequestering Activity Molecular Sequestering Activity Molecular Condensate Scaffold Activity	Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Receptor Ligand Activity Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Pexophagy Temperature Homeostasis Immune System Process Response To Ischemia Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus Autophagy Apoptotic Process Endosome Organization Intracellular Protein Localization Positive Regulation Of Autophagy Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Brown Fat Cell Proliferation Protein K63-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Energy Homeostasis Response To Mitochondrial Depolarisation Negative Regulation Of Ferroptosis Membraneless Organelle Assembly Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm	Cell Morphogenesis Neuron Migration Proteolysis Cell Adhesion Axon Guidance Central Nervous System Development Brain Development Learning Long-term Memory Locomotory Behavior Associative Learning Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Dendrite Development Cell Migration Spinal Cord Patterning Ventral Spinal Cord Development Hippocampus Development Cerebral Cortex Tangential Migration Layer Formation In Cerebral Cortex Cerebral Cortex Development Forebrain Development Positive Regulation Of TOR Signaling Protein Localization To Synapse Reelin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Differentiation Response To Pain Regulation Of Behavior Modulation Of Chemical Synaptic Transmission Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Activity Long-term Synaptic Potentiation Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Maturation Positive Regulation Of Synapse Maturation Postsynaptic Density Assembly NMDA Glutamate Receptor Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Motor Neuron Migration Lateral Motor Column Neuron Migration Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Lateral Motor Column Neuron Migration Interneuron Migration Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Neuron Migration
Pathways		NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Neddylation Interleukin-1 signaling Pexophagy Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2	Reelin signalling pathway
Drugs
Diseases		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)	Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Alzheimer's disease (late onset) ( 24162737) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Adult body size ( 32376654) Alzheimer's disease ( 20452100) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Intraocular pressure ( 29785010) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Metabolite levels (Pyroglutamine) ( 23934736) Morning person ( 30696823) Multiple sclerosis (age of onset) ( 19010793) Night sleep phenotypes ( 27126917) Otosclerosis ( 19230858) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Schizophrenia ( 18282107) Sjögren's syndrome ( 28076899) Sucrose liking ( 31005972) Type 2 diabetes ( 30054458 30297969) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		108 interacting genes: ACAD10 AIM2 ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CALR CAMK2A CCNF CDC37 CDC6 CDK1 CRBN CRYAB CSNK1A1 DAXX DAZAP2 DNAI1 DNAI2 DNAJC10 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPA5 IKBKB IRAK1 KAT5 KCNAB2 KEAP1 KPNA4 LCK LINC01554 LRRK2 MALT1 MAP1LC3B MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MOAP1 MTDH NBR1 NCOR1 NEDD4 NEDD8 NLRP6 NR2F2 NTRK1 NTRK2 NTRK3 OGT PADI1 PAWR PELI1 PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RNF26 RPL37 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIM27 TRIM55 TRIM63 TTN UBA52 UBB ULK2 USP8 VANGL2 VAPB WBP4 WDR81 WEE2-AS1 WWP2 YWHAZ	9 interacting genes: DAB1 EFNB2 EFNB3 LRP8 PCDHA4 PCDHA6 RSPH1 SQSTM1 VLDLR
Entrez ID		8878	5649
HPRD ID		03319	02742
Ensembl ID		ENSG00000161011	ENSG00000189056
Uniprot IDs		Q13501	P78509
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6JM4 6KHZ 6MJ7 6TGY 6TH3 7R1O	8G21
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Signal Transduction Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Cellular Response To Stress Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Growth Factor Transferase Activity Intracellular Signaling Cassette Regulation Of Primary Metabolic Process Protein Kinase Activity Protein-containing Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen-containing Compound Regulation Of Protein Metabolic Process Kinase Activity Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication	Ventral Spinal Cord Development Reelin-mediated Signaling Pathway Nervous System Development Glutamatergic Synapse Reelin Receptor Activity Very-low-density Lipoprotein Particle Receptor Activity Regulation Of Neuron Projection Development System Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Developmental Process Regulation Of Cell Projection Organization Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Dendrite Development Apolipoprotein Binding Layer Formation In Cerebral Cortex Negative Regulation Of Neuron Projection Development Cell Adhesion Cargo Receptor Activity Ephrin Receptor Binding Adult Walking Behavior Negative Regulation Of Cell Projection Organization Walking Behavior Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Projection Organization T Cell Costimulation Calcium Ion Binding Dendrite Morphogenesis Ephrin Receptor Signaling Pathway Negative Regulation Of Axonogenesis Cell Projection Morphogenesis Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Neuron Projection Morphogenesis Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Ammon Gyrus Development Cell Surface Receptor Signaling Pathway Regulation Of Synapse Organization Hippocampus Development Cerebellum Structural Organization Adult Locomotory Behavior Positive Regulation Of Aorta Morphogenesis Virus Receptor Activity Calcium-dependent Protein Binding Brown Fat Cell Proliferation Amphisome Regulation Of Neurogenesis Cell Adhesion Molecule Binding Regulation Of Anatomical Structure Morphogenesis Regulation Of Dendrite Development Lateral Motor Column Neuron Migration Radial Glia Guided Migration Of Purkinje Cell
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