MAP1LC3B and BNIP3

Number of citations of the paper that reports this interaction (PMID 23209295)
11

Data Source:
BioGRID (pull down)

		MAP1LC3B	BNIP3
Gene Name		microtubule-associated protein 1 light chain 3 beta	BCL2/adenovirus E1B 19kDa interacting protein 3
Image
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Autophagic Vacuole Membrane Intracellular Autophagic Vacuole Cytosol Microtubule Axoneme Endomembrane System Extrinsic Component Of Membrane Organelle Membrane Cytoplasmic Vesicle	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Dendrite Integral Component Of Mitochondrial Outer Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Microtubule Binding GABA Receptor Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity GTPase Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Cellular Response To Nitrogen Starvation Nucleophagy Membrane Fusion	Response To Hypoxia Apoptotic Process Cell Death Granzyme-mediated Apoptotic Signaling Pathway Positive Regulation Of Autophagy Negative Regulation Of Mitochondrial Fusion Viral Process Mitochondrial Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Complex Disassembly Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Membrane Potential Regulation Of Mitochondrial Membrane Permeability Autophagic Cell Death Brown Fat Cell Differentiation Neuron Apoptotic Process Defense Response To Virus Response To Hyperoxia Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Cobalt Ion Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrial Outer Membrane Permeabilization Toxin Transport Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Protein-Protein Interactions		50 interactors: AAMP ADD1 ADNP ARFGAP1 ATG3 ATG4A ATG4B ATG7 BNIP3 BRD3 CASP8 CCSER2 CLTA DBI DBN1 DNMT3B EED EPS8 FAM134A FAM65A FUNDC1 FYCO1 GABARAPL2 GORASP2 KBTBD7 KLHL5 KXD1 LUC7L2 MKRN1 MRFAP1 MYBL2 NHP2L1 RAD1 RAP1GAP RPLP1 SAFB SHFM1 SMARCB1 SPAG9 SQSTM1 TAF7 TAX1BP1 TBC1D17 TBC1D25 TBC1D9 TBC1D9B THAP7 TMOD3 TNIP1 UPF2	15 interactors: BCL2 BCL2L1 BNIP3L CD47 CLEC7A CLN8 FATE1 HIVEP1 KTN1 LDLRAD1 MAP1LC3B NCBP1 RHEB TGM2 TMEM11
Entrez ID		81631	664
HPRD ID		14358	04482
Ensembl ID		ENSG00000140941
Uniprot IDs		H6UMI0 Q658J6 Q9GZQ8	Q12983
PDB IDs		1V49 2LUE 2ZJD 3VTU 3VTV 3VTW	2J5D 2KA1 2KA2
Enriched GO Terms of Interacting Partners?		Autophagy Mitochondrion Degradation Organelle Disassembly Nucleophagy Cellular Response To Nitrogen Starvation Macroautophagy Regulation Of Organelle Organization Cellular Response To Starvation Positive Regulation Of Metabolic Process Organelle Organization Positive Regulation Of Autophagy Response To Starvation Cellular Response To Nutrient Levels Autophagic Vacuole Assembly Cellular Response To Extracellular Stimulus Cellular Response To Stress Intracellular Transport Catabolic Process Mitochondrion Organization Regulation Of Cellular Component Organization C-terminal Protein Lipidation Protein Delipidation Membrane Organization Response To Stress Vacuole Organization Regulation Of Autophagy Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Complex Disassembly Establishment Of Localization In Cell Regulation Of Histone Modification Actin Filament Capping Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Localization Negative Regulation Of Actin Filament Depolymerization Response To Nutrient Levels Cellular Component Assembly Protein Localization Regulation Of Ras Protein Signal Transduction Response To Extracellular Stimulus Response To Cobalt Ion Protein Targeting To Membrane Regulation Of Actin Filament Depolymerization Organelle Assembly Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Macroautophagy Negative Regulation Of Histone Acetylation	Mitochondrion Organization Mitochondrial Membrane Organization Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Apoptotic Mitochondrial Changes Response To Other Organism Negative Regulation Of Anoikis Response To Biotic Stimulus Regulation Of Anoikis Membrane Organization Mitochondrial Transport Release Of Cytochrome C From Mitochondria Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Endoplasmic Reticulum Calcium Ion Homeostasis Response To External Stimulus Positive Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death Transport Positive Regulation Of Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Virus Endocytosis Response To Gamma Radiation Phagocytosis Neuron Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Death Negative Regulation Of Cellular PH Reduction CD8-positive, Alpha-beta T Cell Lineage Commitment Apoptotic Process In Bone Marrow Negative Regulation Of Retinal Cell Programmed Cell Death Ovarian Follicle Development Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Stress Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine L-glutamate Uptake Involved In Synaptic Transmission Negative Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Programmed Cell Death Positive Regulation Of Inflammatory Response Ovulation Cycle Process
Tagcloud ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	accepted atg autophagy biomedical carbohydrate comprehensive discovery distributed diverse elucidating families great interest interesting lectins modulating origin perspective pharmacological plant problems raf representative respect summarize thousands ubiquitously widely working
Tagcloud (Difference) ?		akt1 antipsychotic atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	accepted biomedical carbohydrate comprehensive discovery distributed diverse elucidating families great interest interesting lectins modulating origin perspective pharmacological plant problems raf representative respect summarize thousands ubiquitously widely working
Tagcloud (Intersection) ?		atg autophagy