SQSTM1 and MBP

Number of citations of the paper that reports this interaction (PMID 14702098)
7

Data Source:
BioGRID (pull down)

		SQSTM1	MBP
Gene Name		sequestosome 1	myelin basic protein
Image
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Lysosome Late Endosome Autophagic Vacuole Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Cytoplasmic Vesicle Extracellular Vesicular Exosome	Nucleus Plasma Membrane Internode Region Of Axon Neuronal Cell Body Compact Myelin
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding K63-linked Polyubiquitin Binding	Protease Binding Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Positive Regulation Of Protein Phosphorylation Immune System Process Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Protein Localization Endosomal Transport Macroautophagy Positive Regulation Of Macroautophagy Cell Differentiation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Protein Heterooligomerization Apoptotic Signaling Pathway	Immune Response Synaptic Transmission Central Nervous System Development Aging Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Response To Progesterone Response To Tumor Necrosis Factor Myelination Response To Mercury Ion Negative Regulation Of Axonogenesis Membrane Organization Response To Fatty Acid
Pathways		Signaling by Interleukins Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes Cell death signalling via NRAGE, NRIF and NADE NRIF signals cell death from the nucleus p75NTR signals via NF-kB Cytokine Signaling in Immune system Interleukin-1 signaling p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS			Age-related macular degeneration (GA) ( 22705344)
Protein-Protein Interactions		74 interactors: ATXN3 BCL2 BMPR1B BPTF CALM1 CAMK2A CCNB1 CDC37 CDK1 CSNK2A1 DAZAP2 EEF1D EGLN3 FKBP4 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 IRAK1 KCNAB2 KEAP1 LCK LINC00341 MALT1 MAP1LC3A MAP1LC3B MAP2K5 MAP3K3 MAPK14 MBP MEIS2 MLH1 NBR1 NCOR1 NR2F2 NTRK1 NTRK2 NTRK3 OPTN PAWR PIK3CA PPHLN1 PRKCI PRKCZ RAD23A RELN RIPK1 RPL37 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53 TRAF6 TRIM55 TRIM63 TTN UBA52 UBB UBC ULK1 ULK2 YWHAZ	72 interactors: ABL1 APTX ATN1 ATXN1 BMP2K CCNC CCNH CCNT1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPKAPK5 MELK MICU2 MKNK1 MMP7 MNAT1 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1
Entrez ID		8878	4155
HPRD ID		03319	01158
Ensembl ID		ENSG00000161011	ENSG00000197971
Uniprot IDs		Q13501	P02686
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV	1BX2 1FV1 1HQR 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?		Cell Communication Response To Growth Factor Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Phosphorylation Cellular Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Positive Regulation Of Kinase Activity Regulation Of Cell Death Negative Regulation Of Cell Death Response To Organic Substance Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Protein Phosphorylation Activation Of Protein Kinase Activity Membrane Organization Neurotrophin TRK Receptor Signaling Pathway Cellular Component Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cellular Response To Stress	Protein Phosphorylation Phosphorylation Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Signal Transduction By Phosphorylation Protein Autophosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Protein Kinase Activity Peptidyl-threonine Phosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway MAPK Cascade Cellular Response To Stress Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Response To Stimulus Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Death Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Response To Stimulus Regulation Of MAP Kinase Activity Apoptotic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Intersection) ?