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SQSTM1 and DAZAP2
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid, two hybrid)
SQSTM1
DAZAP2
Description
sequestosome 1
DAZ associated protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Phagophore Assembly Site
P-body
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Lysosome
Endosome
Late Endosome
Autophagosome
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Sarcomere
Cytoplasmic Vesicle
Intracellular Membraneless Organelle
Amphisome
Autolysosome
Synapse
Extracellular Exosome
Sperm Midpiece
Lewy Body
Glutamatergic Synapse
Nucleus
Cytoplasm
Cytoplasmic Stress Granule
Nuclear Body
Nuclear Speck
Protein-containing Complex
Molecular Function
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Ionotropic Glutamate Receptor Binding
Signaling Receptor Activity
SH2 Domain Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Ubiquitin-modified Protein Reader Activity
Protein Sequestering Activity
Molecular Sequestering Activity
Molecular Condensate Scaffold Activity
P53 Binding
Transcription Coactivator Activity
Protein Binding
Receptor Tyrosine Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
WW Domain Binding
Protein Serine/threonine Kinase Binding
DNA-binding Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Autophagy Of Mitochondrion
Mitophagy
Pexophagy
Temperature Homeostasis
Immune System Process
Response To Ischemia
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Import Into Nucleus
Autophagy
Apoptotic Process
Endosome Organization
Intracellular Protein Localization
Positive Regulation Of Autophagy
Regulation Of Mitochondrion Organization
Endosomal Transport
Macroautophagy
Cell Differentiation
Protein Catabolic Process
Negative Regulation Of Protein Ubiquitination
Cellular Response To Stress
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Intracellular Signal Transduction
Aggrephagy
Positive Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Regulation Of Protein Complex Stability
Brown Fat Cell Proliferation
Protein K63-linked Ubiquitination
Protein Targeting To Vacuole Involved In Autophagy
Energy Homeostasis
Response To Mitochondrial Depolarisation
Negative Regulation Of Ferroptosis
Membraneless Organelle Assembly
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Protein Localization To Perinuclear Region Of Cytoplasm
Protein Destabilization
Stress Granule Assembly
Positive Regulation Of DNA-templated Transcription
Pathways
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
PINK1-PRKN Mediated Mitophagy
Neddylation
Interleukin-1 signaling
Pexophagy
Signaling by ALK fusions and activated point mutants
KEAP1-NFE2L2 pathway
Nuclear events mediated by NFE2L2
Drugs
Diseases
Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS
Alzheimer's disease (late onset) (
24162737
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Interacting Genes
108 interacting genes:
ACAD10
AIM2
ATXN3
BCL2
BMPR1B
BPTF
BRCA1
CALCR
CALM1
CALR
CAMK2A
CCNF
CDC37
CDC6
CDK1
CRBN
CRYAB
CSNK1A1
DAXX
DAZAP2
DNAI1
DNAI2
DNAJC10
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
HSPA5
IKBKB
IRAK1
KAT5
KCNAB2
KEAP1
KPNA4
LCK
LINC01554
LRRK2
MALT1
MAP1LC3B
MAP2K5
MAPK13
MAPK14
MAPT
MBP
MEIS2
MLH1
MOAP1
MTDH
NBR1
NCOR1
NEDD4
NEDD8
NLRP6
NR2F2
NTRK1
NTRK2
NTRK3
OGT
PADI1
PAWR
PELI1
PIK3CA
PIK3R1
PPHLN1
PRKCD
PRKCI
PRKCZ
RAD23A
RAD54L2
RELN
RIPK1
RNF166
RNF168
RNF26
RPL37
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TGFBR1
TKT
TOE1
TP53INP1
TRAF6
TRIM27
TRIM55
TRIM63
TTN
UBA52
UBB
ULK2
USP8
VANGL2
VAPB
WBP4
WDR81
WEE2-AS1
WWP2
YWHAZ
168 interacting genes:
AATF
ACOT7
AOC1
ARID5A
ATXN1
ATXN1L
BAG3
BATF2
BHLHE40
C1orf94
CALCOCO2
CAMK2A
CAPN15
CCDC120
CDK4
CELF5
CEP70
CLASRP
COL4A2
COL4A5
CXCL12
DAB1
DAZ1
DAZL
DCUN1D1
DESI1
DTX2
EPN1
EPN2
EPN3
ESRP1
EXD3
FAM168A
FAM83A
FBN3
FOXH1
GGA3
GPS2
GPSM1
HEY1
HGS
HIP1
HIPK2
INCA1
KLHL42
KRTAP19-1
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP26-1
KRTAP6-1
KRTAP6-2
KRTAP8-1
LASP1
LGALS9
LITAF
LMO2
MAGED1
MAPK1IP1L
MED31
MINDY1
MINDY3
MTURN
MYEOV
MYOZ3
NDUFA5
NEDD4
NEDD4L
NOC4L
NOTCH1
OPTN
OTUB2
OTUD7B
OTULIN
PATZ1
PDIK1L
PEF1
PITX2
PLEKHB2
PLEKHF2
PLSCR1
PLSCR4
POGZ
POLI
PROP1
PRR13
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PRR34
RABGEF1
RAD18
RAD23A
RAMAC
RBFOX1
RBFOX2
RBM11
RBM24
RBM43
RBPMS
RHOXF2
RNF115
RNF208
RNF44
ROR2
RPS27A
RUNX1
SEPTIN2
SIAH1
SMAP2
SMURF2
SNRPC
SOX10
SOX6
SPMIP9
SQSTM1
STAM2
STAT6
TAX1BP1
TBX6
TCF7L2
TENT5B
TENT5C
TFG
TIAL1
TLE1
TLE5
TNIP1
TNIP3
TOLLIP
TOM1
TP53
UBA52
UBAC1
UBAP2
UBASH3A
UBASH3B
UBB
UBC
UBE2D4
UBE2E2
UBE2E3
UBE2V1
UBE3A
UBQLN1
UBQLN2
UBQLN4
UBXN6
UBXN7
USP13
USP5
VENTX
VEZF1
VHLL
VPS37C
WDR73
WWOX
WWP1
YOD1
ZBTB32
ZC3H10
ZFAND2A
ZFAND2B
ZFYVE9
ZNF34
ZNF581
Entrez ID
8878
9802
HPRD ID
03319
08463
Ensembl ID
ENSG00000161011
ENSG00000183283
Uniprot IDs
Q13501
Q15038
PDB IDs
1Q02
2JY7
2JY8
2K0B
2KNV
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
6JM4
6KHZ
6MJ7
6TGY
6TH3
7R1O
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Regulation Of Signal Transduction
Response To Stress
Regulation Of Cell Communication
Regulation Of Signaling
Cytoplasm
Signal Transduction
Positive Regulation Of Metabolic Process
Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Cytosol
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Metabolic Process
Protein Modification Process
Regulation Of Programmed Cell Death
Positive Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Regulation Of Gene Expression
Cellular Response To Stress
Regulation Of Apoptotic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Regulation Of Multicellular Organismal Process
Positive Regulation Of Macromolecule Biosynthetic Process
Response To Growth Factor
Transferase Activity
Intracellular Signaling Cassette
Regulation Of Primary Metabolic Process
Protein Kinase Activity
Protein-containing Complex
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
MAPK Cascade
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Growth Factor Stimulus
Cellular Response To Oxygen-containing Compound
Regulation Of Protein Metabolic Process
Kinase Activity
Modification-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Serine/threonine Kinase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Post-translational Protein Modification
Ubiquitin Binding
Nucleus
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Nucleoplasm
Modification-dependent Protein Catabolic Process
Proteolysis
Proteolysis Involved In Protein Catabolic Process
Autophagy
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
K48-linked Deubiquitinase Activity
Negative Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Catabolic Process
Cytoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cysteine-type Deubiquitinase Activity
Positive Regulation Of Metabolic Process
Macroautophagy
Protein K48-linked Deubiquitination
Negative Regulation Of Signal Transduction
Cysteine-type Peptidase Activity
Protein Modification Process
Ubiquitin-protein Transferase Activity
Protein K63-linked Ubiquitination
Negative Regulation Of Transcription By RNA Polymerase II
Ubiquitin Protein Ligase Binding
Regulation Of DNA-templated Transcription
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Protein Tag Activity
Protein Metabolic Process
Identical Protein Binding
Cytosol
Autophagosome
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Modification By Small Protein Removal
Clathrin Binding
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Macroautophagy
Establishment Of Protein Localization To Vacuole
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Tagcloud (Intersection)
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