SQSTM1 and NLRP6

Number of citations of the paper that reports this interaction (PubMedID 36223738)
0

Data Source:
BioGRID (pull down)

		SQSTM1	NLRP6
Description		sequestosome 1	NLR family pyrin domain containing 6
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GO Annotations	Cellular Component	Phagophore Assembly Site P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Endosome Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Cytoplasmic Vesicle Intracellular Membraneless Organelle Amphisome Autolysosome Synapse Extracellular Exosome Sperm Midpiece Lewy Body Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Membraneless Organelle Canonical Inflammasome Complex NLRP6 Inflammasome Complex
	Molecular Function	Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-modified Protein Reader Activity Protein Sequestering Activity Molecular Sequestering Activity Molecular Condensate Scaffold Activity	Nucleotide Binding Lipopolysaccharide Binding Double-stranded RNA Binding Vasopressin Receptor Activity ATP Binding Signaling Adaptor Activity Signaling Receptor Activity Pattern Recognition Receptor Activity Peptide Binding Lipoteichoic Acid Binding Molecular Condensate Scaffold Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Pexophagy Temperature Homeostasis Immune System Process Response To Ischemia Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus Autophagy Apoptotic Process Endosome Organization Intracellular Protein Localization Positive Regulation Of Autophagy Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Brown Fat Cell Proliferation Protein K63-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Energy Homeostasis Response To Mitochondrial Depolarisation Negative Regulation Of Ferroptosis Membraneless Organelle Assembly Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm	Immune System Process Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Protein Secretion Response To Bacterium Regulation Of Autophagy Negative Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Negative Regulation Of Toll-like Receptor Signaling Pathway Interleukin-18-mediated Signaling Pathway Wound Healing Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Innate Immune Response Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of Immune Response Defense Response To Gram-positive Bacterium Protein Homooligomerization Protein Maturation Defense Response To Virus Regulation Of Mucus Secretion Necroptotic Process Pyroptotic Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Neutrophil-mediated Killing Of Gram-positive Bacterium Antiviral Innate Immune Response NLRP6 Inflammasome Complex Assembly Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways		NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Neddylation Interleukin-1 signaling Pexophagy Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2
Drugs
Diseases		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Alzheimer's disease (late onset) ( 24162737) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)
Interacting Genes		108 interacting genes: ACAD10 AIM2 ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CALR CAMK2A CCNF CDC37 CDC6 CDK1 CRBN CRYAB CSNK1A1 DAXX DAZAP2 DNAI1 DNAI2 DNAJC10 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPA5 IKBKB IRAK1 KAT5 KCNAB2 KEAP1 KPNA4 LCK LINC01554 LRRK2 MALT1 MAP1LC3B MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MOAP1 MTDH NBR1 NCOR1 NEDD4 NEDD8 NLRP6 NR2F2 NTRK1 NTRK2 NTRK3 OGT PADI1 PAWR PELI1 PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RNF26 RPL37 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIM27 TRIM55 TRIM63 TTN UBA52 UBB ULK2 USP8 VANGL2 VAPB WBP4 WDR81 WEE2-AS1 WWP2 YWHAZ	6 interacting genes: ATG12 ATG16L1 ATG5 BECN1 PIK3R1 SQSTM1
Entrez ID		8878	171389
HPRD ID		03319	14806
Ensembl ID		ENSG00000161011	ENSG00000174885
Uniprot IDs		Q13501	P59044
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6JM4 6KHZ 6MJ7 6TGY 6TH3 7R1O	6NCV 6NDJ
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Signal Transduction Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Cellular Response To Stress Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Growth Factor Transferase Activity Intracellular Signaling Cassette Regulation Of Primary Metabolic Process Protein Kinase Activity Protein-containing Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen-containing Compound Regulation Of Protein Metabolic Process Kinase Activity Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication	Autophagosome Macroautophagy Atg12-Atg5-Atg16 Complex Autophagy Of Mitochondrion Autophagy Autophagosome Assembly Autophagosome Organization Regulation Of Autophagy Phagophore Assembly Site Membrane Microautophagy Regulation Of Innate Immune Response Positive Regulation Of Viral Translation Vacuole Organization Positive Regulation Of Autophagy Atg8-family Ligase Activity Negative Stranded Viral RNA Replication Organelle Assembly Mitophagy Regulation Of Defense Response Response To Mitochondrial Depolarisation Response To Iron(II) Ion Positive Regulation Of Stress Granule Assembly Viral RNA Genome Replication Regulation Of Immune Response Cellular Response To Nitrogen Starvation Regulation Of Stress Granule Assembly Transferase Complex Regulation Of Cellular Component Organization Intracellular Transport Regulation Of Organelle Organization Aggrephagy Regulation Of Autophagosome Maturation Negative Regulation Of Immune System Process Phosphatidylinositol 3-kinase Binding Negative Regulation Of Defense Response To Virus Positive Regulation Of Catabolic Process Piecemeal Microautophagy Of The Nucleus Viral Genome Replication Nucleophagy Regulation Of Macroautophagy Cellular Localization Establishment Of Localization In Cell Regulation Of Immune System Process Phagophore Assembly Site Response To Iron Ion Regulation Of Toll-like Receptor 4 Signaling Pathway GTPase Binding Defense Response To Virus Nucleobase-containing Compound Biosynthetic Process Catabolic Process
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