SQSTM1 and NTRK1

Number of citations of the paper that reports this interaction (PMID 10747026)
88

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SQSTM1	NTRK1
Gene Name		sequestosome 1	neurotrophic tyrosine kinase, receptor, type 1
Image
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Lysosome Late Endosome Autophagic Vacuole Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Cytoplasmic Vesicle Extracellular Vesicular Exosome	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Dendrite Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Neuronal Cell Body Protein Complex Receptor Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding K63-linked Polyubiquitin Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Nerve Growth Factor Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Immune System Process Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Protein Localization Endosomal Transport Macroautophagy Positive Regulation Of Macroautophagy Cell Differentiation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Protein Heterooligomerization Apoptotic Signaling Pathway	Activation Of MAPKK Activity Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Aging Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Developmental Programmed Cell Death Positive Regulation Of Neuron Projection Development Response To Activity Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development B Cell Differentiation Response To Nutrient Levels Positive Regulation Of Ras GTPase Activity Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Response To Drug Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Sympathetic Nervous System Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrostatic Pressure Response To Electrical Stimulus Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Axonogenesis Involved In Innervation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Nerve Growth Factor Stimulus
Pathways		Signaling by Interleukins Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes Cell death signalling via NRAGE, NRIF and NADE NRIF signals cell death from the nucleus p75NTR signals via NF-kB Cytokine Signaling in Immune system Interleukin-1 signaling p75 NTR receptor-mediated signalling	Retrograde neurotrophin signalling Signalling to ERKs Signalling by NGF Prolonged ERK activation events Activation of TRKA receptors NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF PI3K/AKT activation Signalling to RAS Signalling to STAT3 NGF-independant TRKA activation PLC-gamma1 signalling Signalling to p38 via RIT and RIN Frs2-mediated activation
Drugs			Amitriptyline Imatinib Regorafenib
Diseases
GWAS
Protein-Protein Interactions		74 interactors: ATXN3 BCL2 BMPR1B BPTF CALM1 CAMK2A CCNB1 CDC37 CDK1 CSNK2A1 DAZAP2 EEF1D EGLN3 FKBP4 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 IRAK1 KCNAB2 KEAP1 LCK LINC00341 MALT1 MAP1LC3A MAP1LC3B MAP2K5 MAP3K3 MAPK14 MBP MEIS2 MLH1 NBR1 NCOR1 NR2F2 NTRK1 NTRK2 NTRK3 OPTN PAWR PIK3CA PPHLN1 PRKCI PRKCZ RAD23A RELN RIPK1 RPL37 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53 TRAF6 TRIM55 TRIM63 TTN UBA52 UBB UBC ULK1 ULK2 YWHAZ	36 interactors: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 FRS2 FRS3 GIPC1 GRB2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4 NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		8878	4914
HPRD ID		03319	01869
Ensembl ID		ENSG00000161011	ENSG00000198400
Uniprot IDs		Q13501	P04629
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV	1HE7 1SHC 1WWA 1WWW 2IFG 4AOJ 4F0I 4GT5
Enriched GO Terms of Interacting Partners?		Cell Communication Response To Growth Factor Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Phosphorylation Cellular Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Positive Regulation Of Kinase Activity Regulation Of Cell Death Negative Regulation Of Cell Death Response To Organic Substance Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Protein Phosphorylation Activation Of Protein Kinase Activity Membrane Organization Neurotrophin TRK Receptor Signaling Pathway Cellular Component Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cellular Response To Stress	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Kinase Activity Cell Communication Regulation Of Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Cellular Response To Insulin Stimulus Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Catalytic Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Positive Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Peptide Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Response To Stimulus Response To Peptide Hormone Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Response To Fibroblast Growth Factor Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc
Tagcloud (Intersection) ?