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SQSTM1 and NTRK1
Number of citations of the paper that reports this interaction (PubMedID
10747026
)
58
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
SQSTM1
NTRK1
Description
sequestosome 1
neurotrophic receptor tyrosine kinase 1
Image
GO Annotations
Cellular Component
Phagophore Assembly Site
P-body
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Lysosome
Endosome
Late Endosome
Autophagosome
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Sarcomere
Cytoplasmic Vesicle
Intracellular Membraneless Organelle
Amphisome
Autolysosome
Synapse
Extracellular Exosome
Sperm Midpiece
Lewy Body
Glutamatergic Synapse
Cytoplasm
Mitochondrion
Endosome
Early Endosome
Late Endosome
Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Axon
Dendrite
Early Endosome Membrane
Late Endosome Membrane
Protein-containing Complex
Neuronal Cell Body
Receptor Complex
Recycling Endosome
Recycling Endosome Membrane
Molecular Function
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Ionotropic Glutamate Receptor Binding
Signaling Receptor Activity
SH2 Domain Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Ubiquitin-modified Protein Reader Activity
Protein Sequestering Activity
Molecular Sequestering Activity
Molecular Condensate Scaffold Activity
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
GPI-linked Ephrin Receptor Activity
Neurotrophin Receptor Activity
Neurotrophin P75 Receptor Binding
Protein Binding
ATP Binding
Nerve Growth Factor Receptor Activity
Kinase Activity
Transferase Activity
Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Autophagy Of Mitochondrion
Mitophagy
Pexophagy
Temperature Homeostasis
Immune System Process
Response To Ischemia
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Import Into Nucleus
Autophagy
Apoptotic Process
Endosome Organization
Intracellular Protein Localization
Positive Regulation Of Autophagy
Regulation Of Mitochondrion Organization
Endosomal Transport
Macroautophagy
Cell Differentiation
Protein Catabolic Process
Negative Regulation Of Protein Ubiquitination
Cellular Response To Stress
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Intracellular Signal Transduction
Aggrephagy
Positive Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Regulation Of Protein Complex Stability
Brown Fat Cell Proliferation
Protein K63-linked Ubiquitination
Protein Targeting To Vacuole Involved In Autophagy
Energy Homeostasis
Response To Mitochondrial Depolarisation
Negative Regulation Of Ferroptosis
Membraneless Organelle Assembly
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Protein Localization To Perinuclear Region Of Cytoplasm
Protein Phosphorylation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Spermatogenesis
Nervous System Development
Axon Guidance
Learning Or Memory
Circadian Rhythm
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Programmed Cell Death Involved In Cell Development
Positive Regulation Of Neuron Projection Development
Peptidyl-tyrosine Phosphorylation
Olfactory Nerve Development
Cell Differentiation
B Cell Differentiation
Neuron Projection Development
Response To Nutrient Levels
Response To Nicotine
Peptidyl-tyrosine Autophosphorylation
Nerve Growth Factor Signaling Pathway
Mechanoreceptor Differentiation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Sympathetic Nervous System Development
Neuron Development
Response To Axon Injury
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of NF-kappaB Transcription Factor Activity
Neuron Apoptotic Process
Response To Hydrostatic Pressure
Response To Electrical Stimulus
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synapse Assembly
Positive Regulation Of Synaptic Transmission, Glutamatergic
Sertoli Cell Development
Innervation
Axonogenesis Involved In Innervation
Behavioral Response To Formalin Induced Pain
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Nicotine
Cellular Response To Growth Factor Stimulus
Cellular Response To Amyloid-beta
Cellular Response To Nerve Growth Factor Stimulus
Pathways
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
PINK1-PRKN Mediated Mitophagy
Neddylation
Interleukin-1 signaling
Pexophagy
Signaling by ALK fusions and activated point mutants
KEAP1-NFE2L2 pathway
Nuclear events mediated by NFE2L2
PLC-gamma1 signalling
Signalling to RAS
ARMS-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
NGF-independant TRKA activation
TRKA activation by NGF
TRKA activation by NGF
Signalling to p38 via RIT and RIN
PI3K/AKT activation
PI3K/AKT activation
Signalling to STAT3
Drugs
Amitriptyline
Imatinib
Regorafenib
Entrectinib
Fostamatinib
Cenegermin
Larotrectinib
Pralsetinib
Diseases
Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
Neuroblastoma
Thyroid cancer
GWAS
Alzheimer's disease (late onset) (
24162737
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Red cell distribution width (
32888494
)
Interacting Genes
108 interacting genes:
ACAD10
AIM2
ATXN3
BCL2
BMPR1B
BPTF
BRCA1
CALCR
CALM1
CALR
CAMK2A
CCNF
CDC37
CDC6
CDK1
CRBN
CRYAB
CSNK1A1
DAXX
DAZAP2
DNAI1
DNAI2
DNAJC10
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
HSPA5
IKBKB
IRAK1
KAT5
KCNAB2
KEAP1
KPNA4
LCK
LINC01554
LRRK2
MALT1
MAP1LC3B
MAP2K5
MAPK13
MAPK14
MAPT
MBP
MEIS2
MLH1
MOAP1
MTDH
NBR1
NCOR1
NEDD4
NEDD8
NLRP6
NR2F2
NTRK1
NTRK2
NTRK3
OGT
PADI1
PAWR
PELI1
PIK3CA
PIK3R1
PPHLN1
PRKCD
PRKCI
PRKCZ
RAD23A
RAD54L2
RELN
RIPK1
RNF166
RNF168
RNF26
RPL37
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TGFBR1
TKT
TOE1
TP53INP1
TRAF6
TRIM27
TRIM55
TRIM63
TTN
UBA52
UBB
ULK2
USP8
VANGL2
VAPB
WBP4
WDR81
WEE2-AS1
WWP2
YWHAZ
41 interacting genes:
ABL1
ARHGAP32
CAV1
CRK
DNAJA3
DYNLL1
ERBB2
FRS2
FRS3
GIPC1
GRB2
HIPK2
IRS1
IRS2
KIDINS220
MAPK3
MATK
NEDD4L
NGF
NGFR
NTF3
PIK3R1
PLCG1
PTPN1
PTPN11
PTPRR
RAP1A
RASA1
RASGRF1
RUSC1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TPTE
TRAF4
TRAF6
UBB
Entrez ID
8878
4914
HPRD ID
03319
01869
Ensembl ID
ENSG00000161011
ENSG00000198400
Uniprot IDs
Q13501
P04629
X5DR71
PDB IDs
1Q02
2JY7
2JY8
2K0B
2KNV
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
6JM4
6KHZ
6MJ7
6TGY
6TH3
7R1O
1HE7
1SHC
1WWA
1WWW
2IFG
2N90
4AOJ
4CRP
4F0I
4GT5
4PMM
4PMP
4PMS
4PMT
4YNE
4YPS
5H3Q
5I8A
5JFS
5JFV
5JFW
5JFX
5KMI
5KMJ
5KMK
5KML
5KMM
5KMN
5KMO
5KVT
5WR7
6D1Y
6D1Z
6D20
6D22
6DKB
6DKG
6DKI
6DKW
6IQN
6J5L
6NPT
6NSP
6NSS
6PL1
6PL2
6PL3
6PL4
6PMA
6PMB
6PMC
6PME
7N3T
7VKM
7VKN
7VKO
7XAF
7XBI
8J5W
8J5X
8J61
8J63
8YTD
8YTE
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Regulation Of Signal Transduction
Response To Stress
Regulation Of Cell Communication
Regulation Of Signaling
Cytoplasm
Signal Transduction
Positive Regulation Of Metabolic Process
Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Cytosol
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Metabolic Process
Protein Modification Process
Regulation Of Programmed Cell Death
Positive Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Regulation Of Gene Expression
Cellular Response To Stress
Regulation Of Apoptotic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Regulation Of Multicellular Organismal Process
Positive Regulation Of Macromolecule Biosynthetic Process
Response To Growth Factor
Transferase Activity
Intracellular Signaling Cassette
Regulation Of Primary Metabolic Process
Protein Kinase Activity
Protein-containing Complex
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
MAPK Cascade
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Growth Factor Stimulus
Cellular Response To Oxygen-containing Compound
Regulation Of Protein Metabolic Process
Kinase Activity
Modification-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Serine/threonine Kinase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Phosphotyrosine Residue Binding
Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cytosol
Positive Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
ERBB Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Neurotrophin TRKA Receptor Binding
Receptor Tyrosine Kinase Binding
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Insulin Receptor Binding
Neurotrophin Signaling Pathway
Plasma Membrane
Regulation Of Apoptotic Process
Nerve Growth Factor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Regulation Of Programmed Cell Death
Intracellular Signaling Cassette
Signaling Adaptor Activity
Cellular Response To Growth Factor Stimulus
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Population Proliferation
Ephrin Receptor Binding
Protein Kinase Binding
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune Response
Positive Regulation Of D-glucose Import
Regulation Of Cell Adhesion
Enzyme Binding
Regulation Of Cellular Localization
SH2 Domain Binding
Insulin-like Growth Factor Receptor Binding
Developmental Process
Positive Regulation Of D-glucose Transmembrane Transport
Regulation Of Biological Quality
Negative Regulation Of Programmed Cell Death
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Tagcloud (Intersection)
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