MAP1LC3B and ATG4B

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		MAP1LC3B	ATG4B
Gene Name		microtubule-associated protein 1 light chain 3 beta	autophagy related 4B, cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Autophagic Vacuole Membrane Intracellular Autophagic Vacuole Cytosol Microtubule Axoneme Endomembrane System Extrinsic Component Of Membrane Organelle Membrane Cytoplasmic Vesicle	Cytoplasm Cytosol
	Molecular Function	Protein Binding Microtubule Binding GABA Receptor Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Cellular Response To Nitrogen Starvation Nucleophagy Membrane Fusion	Autophagic Vacuole Assembly Mitochondrion Degradation C-terminal Protein Lipidation Proteolysis Protein Targeting To Membrane Autophagy Cellular Response To Nitrogen Starvation Positive Regulation Of Autophagy Protein Processing Nucleophagy Positive Regulation Of Protein Catabolic Process Protein Delipidation
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Prostate cancer ( 23535732)
Protein-Protein Interactions		50 interactors: AAMP ADD1 ADNP ARFGAP1 ATG3 ATG4A ATG4B ATG7 BNIP3 BRD3 CASP8 CCSER2 CLTA DBI DBN1 DNMT3B EED EPS8 FAM134A FAM65A FUNDC1 FYCO1 GABARAPL2 GORASP2 KBTBD7 KLHL5 KXD1 LUC7L2 MKRN1 MRFAP1 MYBL2 NHP2L1 RAD1 RAP1GAP RPLP1 SAFB SHFM1 SMARCB1 SPAG9 SQSTM1 TAF7 TAX1BP1 TBC1D17 TBC1D25 TBC1D9 TBC1D9B THAP7 TMOD3 TNIP1 UPF2	6 interactors: GABARAP GABARAPL1 GABARAPL2 LINC00341 MAP1LC3A MAP1LC3B
Entrez ID		81631	23192
HPRD ID		14358	16499
Ensembl ID		ENSG00000140941	ENSG00000168397
Uniprot IDs		H6UMI0 Q658J6 Q9GZQ8	B3KVU2 F5H7P2 F8WD71 Q9Y4P1
PDB IDs		1V49 2LUE 2ZJD 3VTU 3VTV 3VTW	2CY7 2D1I 2Z0D 2Z0E 2ZZP
Enriched GO Terms of Interacting Partners?		Autophagy Mitochondrion Degradation Organelle Disassembly Nucleophagy Cellular Response To Nitrogen Starvation Macroautophagy Regulation Of Organelle Organization Cellular Response To Starvation Positive Regulation Of Metabolic Process Organelle Organization Positive Regulation Of Autophagy Response To Starvation Cellular Response To Nutrient Levels Autophagic Vacuole Assembly Cellular Response To Extracellular Stimulus Cellular Response To Stress Intracellular Transport Catabolic Process Mitochondrion Organization Regulation Of Cellular Component Organization C-terminal Protein Lipidation Protein Delipidation Membrane Organization Response To Stress Vacuole Organization Regulation Of Autophagy Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Complex Disassembly Establishment Of Localization In Cell Regulation Of Histone Modification Actin Filament Capping Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Localization Negative Regulation Of Actin Filament Depolymerization Response To Nutrient Levels Cellular Component Assembly Protein Localization Regulation Of Ras Protein Signal Transduction Response To Extracellular Stimulus Response To Cobalt Ion Protein Targeting To Membrane Regulation Of Actin Filament Depolymerization Organelle Assembly Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Macroautophagy Negative Regulation Of Histone Acetylation	Nucleophagy Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Vacuole Organization Membrane Fusion Cellular Response To Starvation Autophagy Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Mitochondrion Organization Response To Nutrient Levels Cellular Response To Nitrogen Starvation Response To Extracellular Stimulus Organelle Assembly Membrane Organization Cellular Response To Stress Catabolic Process Response To External Stimulus Cellular Component Assembly Organelle Organization Response To Stress Cell Communication Cellular Response To Stimulus Response To Stimulus Positive Regulation Of ATPase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of ATPase Activity Intra-Golgi Vesicle-mediated Transport Negative Regulation Of Proteasomal Protein Catabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Protein Catabolic Process Extrinsic Apoptotic Signaling Pathway
Tagcloud ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	akt1 antipsychotic atg12 atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask