SQSTM1 and CSNK1A1

Number of citations of the paper that reports this interaction (PubMedID 27846364)
50

Data Source:
BioGRID (enzymatic study)

		SQSTM1	CSNK1A1
Description		sequestosome 1	casein kinase 1 alpha 1
Image
GO Annotations	Cellular Component	Phagophore Assembly Site P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Endosome Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Cytoplasmic Vesicle Intracellular Membraneless Organelle Amphisome Autolysosome Synapse Extracellular Exosome Sperm Midpiece Lewy Body Glutamatergic Synapse	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Centrosome Spindle Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cytoskeleton Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Cell Projection Keratin Filament
	Molecular Function	Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-modified Protein Reader Activity Protein Sequestering Activity Molecular Sequestering Activity Molecular Condensate Scaffold Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Pexophagy Temperature Homeostasis Immune System Process Response To Ischemia Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus Autophagy Apoptotic Process Endosome Organization Intracellular Protein Localization Positive Regulation Of Autophagy Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Brown Fat Cell Proliferation Protein K63-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Energy Homeostasis Response To Mitochondrial Depolarisation Negative Regulation Of Ferroptosis Membraneless Organelle Assembly Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm	Autophagosome Assembly Protein Phosphorylation Golgi Organization Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Viral Protein Processing Regulation Of Wnt Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Nutrient Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rho Protein Signal Transduction TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Neddylation Interleukin-1 signaling Pexophagy Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Maturation of nucleoprotein
Drugs			Fostamatinib
Diseases		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Alzheimer's disease (late onset) ( 24162737) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)
Interacting Genes		108 interacting genes: ACAD10 AIM2 ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CALR CAMK2A CCNF CDC37 CDC6 CDK1 CRBN CRYAB CSNK1A1 DAXX DAZAP2 DNAI1 DNAI2 DNAJC10 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPA5 IKBKB IRAK1 KAT5 KCNAB2 KEAP1 KPNA4 LCK LINC01554 LRRK2 MALT1 MAP1LC3B MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MOAP1 MTDH NBR1 NCOR1 NEDD4 NEDD8 NLRP6 NR2F2 NTRK1 NTRK2 NTRK3 OGT PADI1 PAWR PELI1 PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RNF26 RPL37 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIM27 TRIM55 TRIM63 TTN UBA52 UBB ULK2 USP8 VANGL2 VAPB WBP4 WDR81 WEE2-AS1 WWP2 YWHAZ	51 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC ATM AXIN1 BID CDC25A CEBPA CHRM3 CRBN CREM CTNNB1 CUL4B EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MDM4 NFATC3 NLRP3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 USP15 UVRAG YWHAQ YWHAZ
Entrez ID		8878	1452
HPRD ID		03319	02739
Ensembl ID		ENSG00000161011	ENSG00000113712
Uniprot IDs		Q13501	B4DER9 P48729 Q6PJ06
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6JM4 6KHZ 6MJ7 6TGY 6TH3 7R1O	5FQD 6GZD 7WTT 8G66
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Signal Transduction Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Cellular Response To Stress Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Growth Factor Transferase Activity Intracellular Signaling Cassette Regulation Of Primary Metabolic Process Protein Kinase Activity Protein-containing Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen-containing Compound Regulation Of Protein Metabolic Process Kinase Activity Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication	Protein-containing Complex Signal Transduction Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Development Ubiquitin Protein Ligase Binding Protein Domain Specific Binding Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Development Cytosol Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Cellular Component Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of T Cell Activation Regulation Of Metabolic Process Regulation Of Stem Cell Proliferation T Cell Differentiation In Thymus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Lung Development Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Intracellular Signaling Cassette Cytoplasm Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Apoptotic Process
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