MAP1LC3B and SHFM1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MAP1LC3B	SHFM1
Gene Name		microtubule-associated protein 1 light chain 3 beta	split hand/foot malformation (ectrodactyly) type 1
Image
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Autophagic Vacuole Membrane Intracellular Autophagic Vacuole Cytosol Microtubule Axoneme Endomembrane System Extrinsic Component Of Membrane Organelle Membrane Cytoplasmic Vesicle	Proteasome Complex Integrator Complex
	Molecular Function	Protein Binding Microtubule Binding GABA Receptor Binding	Protein Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Cellular Response To Nitrogen Starvation Nucleophagy Membrane Fusion	Double-strand Break Repair Via Homologous Recombination
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Attention deficit hyperactivity disorder ( 20732625) Immunoglobulin A ( 20694011)
Protein-Protein Interactions		50 interactors: AAMP ADD1 ADNP ARFGAP1 ATG3 ATG4A ATG4B ATG7 BNIP3 BRD3 CASP8 CCSER2 CLTA DBI DBN1 DNMT3B EED EPS8 FAM134A FAM65A FUNDC1 FYCO1 GABARAPL2 GORASP2 KBTBD7 KLHL5 KXD1 LUC7L2 MKRN1 MRFAP1 MYBL2 NHP2L1 RAD1 RAP1GAP RPLP1 SAFB SHFM1 SMARCB1 SPAG9 SQSTM1 TAF7 TAX1BP1 TBC1D17 TBC1D25 TBC1D9 TBC1D9B THAP7 TMOD3 TNIP1 UPF2	7 interactors: BRCA1 BRCA2 MAP1LC3B NUDT21 PCID2 PSMD3 PSMD6
Entrez ID		81631	7979
HPRD ID		14358	03182
Ensembl ID		ENSG00000140941
Uniprot IDs		H6UMI0 Q658J6 Q9GZQ8	P60896 Q6IBB7
PDB IDs		1V49 2LUE 2ZJD 3VTU 3VTV 3VTW	1IYJ 1MIU 1MJE 3T5X
Enriched GO Terms of Interacting Partners?		Autophagy Mitochondrion Degradation Organelle Disassembly Nucleophagy Cellular Response To Nitrogen Starvation Macroautophagy Regulation Of Organelle Organization Cellular Response To Starvation Positive Regulation Of Metabolic Process Organelle Organization Positive Regulation Of Autophagy Response To Starvation Cellular Response To Nutrient Levels Autophagic Vacuole Assembly Cellular Response To Extracellular Stimulus Cellular Response To Stress Intracellular Transport Catabolic Process Mitochondrion Organization Regulation Of Cellular Component Organization C-terminal Protein Lipidation Protein Delipidation Membrane Organization Response To Stress Vacuole Organization Regulation Of Autophagy Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Complex Disassembly Establishment Of Localization In Cell Regulation Of Histone Modification Actin Filament Capping Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Localization Negative Regulation Of Actin Filament Depolymerization Response To Nutrient Levels Cellular Component Assembly Protein Localization Regulation Of Ras Protein Signal Transduction Response To Extracellular Stimulus Response To Cobalt Ion Protein Targeting To Membrane Regulation Of Actin Filament Depolymerization Organelle Assembly Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Macroautophagy Negative Regulation Of Histone Acetylation	DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Arrest Regulation Of Cell Cycle Regulation Of Cell Cycle Arrest Regulation Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Protein Ubiquitination DNA Damage Checkpoint Protein Polyubiquitination Cellular Response To Stress Regulation Of Protein Ubiquitination Cell Cycle Checkpoint Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Process Negative Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Centrosome Cycle Programmed Cell Death Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cell Death Death Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Ligase Activity Negative Regulation Of Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	10q24 17p13 cgh cnvs congenital deletions dlx5 duplications dync1i1 eexons encompassing enhancer enhancers exonic exons families foot fourth hearing hs1642 kb malformation microdeletions split syndromic telomeric tp63 unrelated
Tagcloud (Difference) ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	10q24 17p13 cgh cnvs congenital deletions dlx5 duplications dync1i1 eexons encompassing enhancer enhancers exonic exons families foot fourth hearing hs1642 kb malformation microdeletions split syndromic telomeric tp63 unrelated
Tagcloud (Intersection) ?