SH3RF1 and FHL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3RF1	FHL2
Description		SH3 domain containing ring finger 1	four and a half LIM domains 2
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Lamellipodium Cell Projection Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Z Disc
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding BHLH Transcription Factor Binding Metal Ion Binding
	Biological Process	MAPK Cascade Neuron Migration Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Response To Aldosterone Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Response To Hormone Negative Regulation Of Apoptotic Process Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		RHOV GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation	PPARA activates gene expression
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Appendicular lean mass ( 33097823) Bipolar disorder x sex interaction ( 34099189) Body fat mass ( 28552196) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) Walking pace ( 33128006)
Interacting Genes		69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1	175 interacting genes: A1CF ABI1 ABLIM1 ADAM17 AK1 AKIP1 AMOT ANKRD55 APP AR ARHGAP9 ATOSB ATXN1 BANP BARX2 BIN1 BLZF1 BMPR2 BRCA1 CACNA1C CAND2 CAPN1 CARD8 CATSPERT CCDC198 CCDC92 CDC73 CFTR CIMIP1 CKM CREBBP CSK CSN2 CTNNB1 DAPL1 DCP1A DDIT4L DLGAP1 DPF2 DRC4 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FAM204A FHL1 FHL3 FHL5 FOXO1 GATAD2B GLYR1 GMEB2 GNG12 GNG4 GOLGA6A GTF2F2 GTF2H1 HAND1 HCK HSF2BP HSPB2 ID3 IDH1 IER3 IFI35 IGFBP5 IKZF1 IKZF4 IL16 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 KIF5B KLF12 KLHL20 KPRP LDLRAP1 LRIF1 MAGEL2 MBD3L1 MCM7 MDM2 MISP MYBPC1 MYO15B NBPF6 NIBAN1 NRF1 PFKM PHB2 PHF1 PHF21A PKNOX1 PKNOX2 POGZ POU6F2 PRDM11 PRDM6 PRR5L PSEN2 PUF60 QRICH1 RAI2 REL REV1 RFX3 RIPPLY1 RUNX2 SAP30BP SAXO1 SAXO2 SAXO4 SCNM1 SFPQ SH3RF1 SIGLEC6 SLAIN1 SLC34A1 SMAD2 SMAD3 SMAD4 SNAI1 SOX30 SP2 SPRY4 SREBF2 SRF STAT3 SUMO1P1 TCP10L TNFRSF11A TOX3 TRAF6 TRIM55 TRIM63 TRIM73 TTN TXNRD3 VXN WASHC1 WT1 YPEL3 YY1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF143 ZNF200 ZNF212 ZNF23 ZNF3 ZNF331 ZNF408 ZNF410 ZNF417 ZNF620 ZNF626 ZNF638 ZNF655 ZNF85 ZSCAN9
Entrez ID		57630	2274
HPRD ID		15335	04026
Ensembl ID		ENSG00000154447	ENSG00000115641
Uniprot IDs		Q7Z6J0	Q14192 Q2XQU9 Q6I9R8
PDB IDs		7NZC 7NZD	1X4K 1X4L 2D8Z 2MIU
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding MAP Kinase Kinase Kinase Activity Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly JUN Kinase Kinase Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Protein Autophosphorylation Ubiquitin Conjugating Enzyme Activity Lamellipodium Negative Regulation Of Membrane Tubulation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Actin Filament-based Process Regulation Of Protein Modification Process Focal Adhesion Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Modification-dependent Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Proteolysis Involved In Protein Catabolic Process T Cell Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Actin Cytoskeleton Organization Actin Polymerization Or Depolymerization Actomyosin Contractile Ring Assembly JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Apoptotic Process Cell Surface Receptor Signaling Pathway Signal Transduction Protein Polymerization Programmed Cell Death Cell Death Positive Regulation Of Protein Phosphorylation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Cell Communication Protein Modification Process Cytoplasm	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Zinc Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Positive Regulation Of Metabolic Process Transcription Regulator Complex Metal Ion Binding Regulation Of MiRNA Transcription Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-templated Transcription Formation Of Primary Germ Layer Integrin Complex Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex
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