FHL2 and TNFRSF11A

Number of citations of the paper that reports this interaction (PMID 16184196)
18

Data Source:
HPRD (in vivo)

		FHL2	TNFRSF11A
Gene Name		four and a half LIM domains 2	tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Focal Adhesion Actin Cytoskeleton Z Disc M Band	External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding Androgen Receptor Binding	Receptor Activity Transmembrane Signaling Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription, DNA-templated Response To Hormone Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation	Ossification Adaptive Immune Response Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Response To Radiation Osteoclast Differentiation Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Tumor Necrosis Factor Positive Regulation Of JUN Kinase Activity Lymph Node Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Circadian Temperature Homeostasis Mammary Gland Alveolus Development Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Bone mineral density (spine) ( 19801982) Paget's disease ( 21623375 20436471) Response to antipsychotic treatment ( 23241943) Serum albumin level ( 23022100)
Protein-Protein Interactions		92 interactors: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EIF6 EP300 ESR1 FAM129A FAM154A FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HIF1A ID3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MYBPC1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638	13 interactors: CBL CBLB FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6
Entrez ID		2274	8792
HPRD ID		04026	04609
Ensembl ID		ENSG00000115641	ENSG00000141655
Uniprot IDs		J3KNW4 Q14192 Q2XQU9 Q6I9R8	I4EC36 I4EC38 N0GVH0 Q59EP9 Q9Y6Q6
PDB IDs		1X4K 1X4L 2D8Z	1LB5
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Transcription, DNA-templated Formation Of Primary Germ Layer Negative Regulation Of Cellular Metabolic Process Tissue Development Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gastrulation Regulation Of Signaling Anatomical Structure Development Response To Organic Substance Organ Morphogenesis Embryonic Morphogenesis	Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of MAP Kinase Activity Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Activation Of Protein Kinase Activity Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Apoptotic Process Osteoclast Differentiation Signaling Activation Of Innate Immune Response Cell Communication Regulation Of Signaling Regulation Of Cell Death Positive Regulation Of Immune Response Regulation Of Cell-cell Adhesion I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Lymphocyte Activation Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of T Cell Activation Positive Regulation Of MAPK Cascade Cellular Response To Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Positive Regulation Of Protein Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of JUN Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of T Cell Cytokine Production
Tagcloud ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly	allelic atg autophagy becn1 contexts cooperation delays fvb heterozygosity implicating mammary mmtv monoallelic multiparous nfkb nonautophagy palb2 paradoxical parity pymt questioned seemingly suppressive tnbcs tumorigenesis wingless wnt1
Tagcloud (Difference) ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly	allelic atg autophagy becn1 contexts cooperation delays fvb heterozygosity implicating mammary mmtv monoallelic multiparous nfkb nonautophagy palb2 paradoxical parity pymt questioned seemingly suppressive tnbcs tumorigenesis wingless wnt1
Tagcloud (Intersection) ?