FHL2 and AK1

Number of citations of the paper that reports this interaction (PMID 12432079)
54

Data Source:
HPRD (in vitro)

		FHL2	AK1
Gene Name		four and a half LIM domains 2	adenylate kinase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Focal Adhesion Actin Cytoskeleton Z Disc M Band	Outer Dense Fiber Cytoplasm Cytosol Plasma Membrane Sperm Flagellum Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding Androgen Receptor Binding	Adenylate Kinase Activity Nucleoside Diphosphate Kinase Activity ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription, DNA-templated Response To Hormone Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation	Nucleoside Diphosphate Phosphorylation ADP Biosynthetic Process Cell Cycle Arrest Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process AMP Metabolic Process ATP Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs			Bis(Adenosine)-5\'-Pentaphosphate
Diseases
GWAS
Protein-Protein Interactions		92 interactors: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EIF6 EP300 ESR1 FAM129A FAM154A FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HIF1A ID3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MYBPC1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638	6 interactors: APP FHL2 TERF1 TERF2IP TINF2 TRIM63
Entrez ID		2274	203
HPRD ID		04026	00046
Ensembl ID		ENSG00000115641	ENSG00000106992
Uniprot IDs		J3KNW4 Q14192 Q2XQU9 Q6I9R8	P00568 Q5T9B7 Q6FGX9
PDB IDs		1X4K 1X4L 2D8Z	1Z83 2C95
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Transcription, DNA-templated Formation Of Primary Germ Layer Negative Regulation Of Cellular Metabolic Process Tissue Development Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gastrulation Regulation Of Signaling Anatomical Structure Development Response To Organic Substance Organ Morphogenesis Embryonic Morphogenesis	Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase RNA-dependent DNA Replication Regulation Of Chromosome Organization Protein Localization To Chromosome Negative Regulation Of Cellular Metabolic Process Negative Regulation Of DNA Replication Homeostatic Process Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Protein ADP-ribosylation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Collateral Sprouting In Absence Of Injury Telomeric Loop Formation Age-dependent Telomere Shortening Atrial Cardiac Muscle Cell Development Negative Regulation Of Cellular Protein Metabolic Process Telomere Maintenance Via Telomere Shortening Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Protein Glycosylation Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Organelle Organization Collateral Sprouting Axon Midline Choice Point Recognition Protection From Non-homologous End Joining At Telomere Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Skeletal Muscle Atrophy Chromosome Organization DNA Metabolic Process Axon Choice Point Recognition Striated Muscle Atrophy Telomere Assembly
Tagcloud ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly	aids biosynthesis cdk5r2 cycles deepen drugable ephb2 figure hek293t hiv host kinases library ltr nfkappab overlapped p38mapk plasmid prkacb regimens repress rnai shrna silenced stably therapeutics throughput uncovers vital
Tagcloud (Difference) ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly	aids biosynthesis cdk5r2 cycles deepen drugable ephb2 figure hek293t hiv host kinases library ltr nfkappab overlapped p38mapk plasmid prkacb regimens repress rnai shrna silenced stably therapeutics throughput uncovers vital
Tagcloud (Intersection) ?