FHL2 and PRDM6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FHL2	PRDM6
Description		four and a half LIM domains 2	PR/SET domain 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Z Disc	Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding BHLH Transcription Factor Binding Metal Ion Binding	Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Identical Protein Binding Metal Ion Binding Histone H4K20 Monomethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Response To Hormone Negative Regulation Of Apoptotic Process Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Gene Expression Neurogenesis Methylation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Cell Differentiation
Pathways		PPARA activates gene expression
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder x sex interaction ( 34099189) Body fat mass ( 28552196) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) Walking pace ( 33128006)	Body mass index ( 28892062) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618447 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 28196072) Mammographic density (dense area) ( 25342443) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Percent mammographic density ( 25342443) Pulse pressure ( 27841878 27618447) QRS duration ( 25035420) Systolic blood pressure ( 27841878 27618447 26390057 30578418)
Interacting Genes		175 interacting genes: A1CF ABI1 ABLIM1 ADAM17 AK1 AKIP1 AMOT ANKRD55 APP AR ARHGAP9 ATOSB ATXN1 BANP BARX2 BIN1 BLZF1 BMPR2 BRCA1 CACNA1C CAND2 CAPN1 CARD8 CATSPERT CCDC198 CCDC92 CDC73 CFTR CIMIP1 CKM CREBBP CSK CSN2 CTNNB1 DAPL1 DCP1A DDIT4L DLGAP1 DPF2 DRC4 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FAM204A FHL1 FHL3 FHL5 FOXO1 GATAD2B GLYR1 GMEB2 GNG12 GNG4 GOLGA6A GTF2F2 GTF2H1 HAND1 HCK HSF2BP HSPB2 ID3 IDH1 IER3 IFI35 IGFBP5 IKZF1 IKZF4 IL16 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 KIF5B KLF12 KLHL20 KPRP LDLRAP1 LRIF1 MAGEL2 MBD3L1 MCM7 MDM2 MISP MYBPC1 MYO15B NBPF6 NIBAN1 NRF1 PFKM PHB2 PHF1 PHF21A PKNOX1 PKNOX2 POGZ POU6F2 PRDM11 PRDM6 PRR5L PSEN2 PUF60 QRICH1 RAI2 REL REV1 RFX3 RIPPLY1 RUNX2 SAP30BP SAXO1 SAXO2 SAXO4 SCNM1 SFPQ SH3RF1 SIGLEC6 SLAIN1 SLC34A1 SMAD2 SMAD3 SMAD4 SNAI1 SOX30 SP2 SPRY4 SREBF2 SRF STAT3 SUMO1P1 TCP10L TNFRSF11A TOX3 TRAF6 TRIM55 TRIM63 TRIM73 TTN TXNRD3 VXN WASHC1 WT1 YPEL3 YY1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF143 ZNF200 ZNF212 ZNF23 ZNF3 ZNF331 ZNF408 ZNF410 ZNF417 ZNF620 ZNF626 ZNF638 ZNF655 ZNF85 ZSCAN9	71 interacting genes: ABI2 AGXT AHCYL1 AIRIM ANKS1A AQP1 ARID5A ATOSB ATPAF2 ATXN7L2 BAG3 BANF2 BANP CBFA2T2 CBX8 CCDC120 CCDC57 CCHCR1 CCNL1 CEP57L1 COX5B CSTF2 ELOA ENKD1 EXOSC5 FAM90A1 FHL2 FOXD4L1 FRS3 FTO GADD45GIP1 GEM GPANK1 GRXCR1 HOXC8 IL16 IQUB KANK2 KAT5 KCTD9 KIFC3 LMO1 LMO2 LONRF1 MYOZ3 NCK2 NEK6 NFKBID PATZ1 PIH1D2 PRKAA2 PTK6 QARS1 RAD51D ROPN1 RUNX1T1 SAMD4A SLC19A4P STK16 TCAF1 TEKT4 TLE5 TRIM14 TSGA10 TSGA10IP TSSK3 TTC23 TYW2 UBASH3A USP54 ZFYVE26
Entrez ID		2274	93166
HPRD ID		04026	19698
Ensembl ID		ENSG00000115641	ENSG00000061455
Uniprot IDs		Q14192 Q2XQU9 Q6I9R8	Q9NQX0
PDB IDs		1X4K 1X4L 2D8Z 2MIU
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Zinc Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Positive Regulation Of Metabolic Process Transcription Regulator Complex Metal Ion Binding Regulation Of MiRNA Transcription Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-templated Transcription Formation Of Primary Germ Layer Integrin Complex Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex	Protein Binding
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