FHL2 and ITGB6

Number of citations of the paper that reports this interaction (PMID 10906324)
19

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vitro, two hybrid)

		FHL2	ITGB6
Gene Name		four and a half LIM domains 2	integrin, beta 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Focal Adhesion Actin Cytoskeleton Z Disc M Band	Plasma Membrane Integrin Complex External Side Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding Androgen Receptor Binding	Virus Receptor Activity Integrin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription, DNA-templated Response To Hormone Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Multicellular Organismal Development Response To Virus Viral Process Extracellular Matrix Organization
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Molecules associated with elastic fibres Elastic fibre formation ECM proteoglycans Integrin cell surface interactions
Drugs
Diseases
GWAS			Nephropathy (idiopathic membranous) ( 21323541) Type 2 diabetes ( 20418489)
Protein-Protein Interactions		92 interactors: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EIF6 EP300 ESR1 FAM129A FAM154A FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HIF1A ID3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MYBPC1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638	8 interactors: FHL2 FLNA FLNB FN1 ITGAV MAPK1 TGFB1 VTN
Entrez ID		2274	3694
HPRD ID		04026	00947
Ensembl ID		ENSG00000115641	ENSG00000115221
Uniprot IDs		J3KNW4 Q14192 Q2XQU9 Q6I9R8	B4E2B8 C9JA97 E9PEE8 P18564
PDB IDs		1X4K 1X4L 2D8Z	1LH9
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Transcription, DNA-templated Formation Of Primary Germ Layer Negative Regulation Of Cellular Metabolic Process Tissue Development Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gastrulation Regulation Of Signaling Anatomical Structure Development Response To Organic Substance Organ Morphogenesis Embryonic Morphogenesis	Tissue Development Endoderm Development Blood Coagulation Hemostasis Cell Differentiation Endodermal Cell Differentiation Platelet Activation Regulation Of Body Fluid Levels Wound Healing Endoderm Formation Anatomical Structure Morphogenesis Response To Wounding Vesicle-mediated Transport Cell Morphogenesis Involved In Differentiation Platelet Degranulation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Multicellular Organismal Development Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Vesicle-mediated Transport Cell Development Anatomical Structure Formation Involved In Morphogenesis Developmental Process Cell Morphogenesis Formation Of Primary Germ Layer Positive Regulation Of Peptidyl-threonine Phosphorylation ERK1 And ERK2 Cascade Regulation Of Protein Metabolic Process Cell Adhesion Cell-matrix Adhesion Regulation Of Cell Migration Regulation Of Endocytosis Gastrulation Regulation Of Cell Motility System Development Cell-substrate Adhesion Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement MAPK Cascade Positive Regulation Of Transport Lipopolysaccharide-mediated Signaling Pathway Signal Transduction By Phosphorylation Substrate Adhesion-dependent Cell Spreading Cardiovascular System Development Negative Regulation Of Protein Metabolic Process
Tagcloud ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly	adhesion agilent bioinformatics cdc14a cdkn1c cdkn2a clustering col6a3 ctnna3 cycles david differentially distinctly dysregulated experiment focal folds go hoxb4 hyperplastic oligonucletide pairs regulated repeating resources scar scars tgfbeta1 twice
Tagcloud (Difference) ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly	adhesion agilent bioinformatics cdc14a cdkn1c cdkn2a clustering col6a3 ctnna3 cycles david differentially distinctly dysregulated experiment focal folds go hoxb4 hyperplastic oligonucletide pairs regulated repeating resources scar scars tgfbeta1 twice
Tagcloud (Intersection) ?