SH3RF1 and NCF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3RF1	NCF1
Description		SH3 domain containing ring finger 1	neutrophil cytosolic factor 1
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Lamellipodium Cell Projection Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Lipid Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	MAPK Cascade Neuron Migration Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Response To Aldosterone Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Response To Yeast Leukocyte Mediated Cytotoxicity Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Inflammatory Response Cellular Defense Response Response To Bacterium Superoxide Anion Generation Defense Response To Bacterium Innate Immune Response Respiratory Burst Hydrogen Peroxide Biosynthetic Process Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Defense Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Neutrophil-mediated Killing Of Gram-positive Bacterium Neutrophil-mediated Killing Of Fungus Cellular Response To Glucose Stimulus Cellular Response To Testosterone Stimulus Reactive Oxygen Species Metabolic Process Reactive Oxygen Species Biosynthetic Process
Pathways		RHOV GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs			Dextromethorphan
Diseases			Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Systemic lupus erythematosus ( 33493351)
Interacting Genes		69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1	29 interacting genes: ACTB CEBPA CSNK2B FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN RB1 SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		57630	653361
HPRD ID		15335
Ensembl ID		ENSG00000154447	ENSG00000158517
Uniprot IDs		Q7Z6J0	P14598
PDB IDs		7NZC 7NZD	1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP 7YXW 8WEJ
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding MAP Kinase Kinase Kinase Activity Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly JUN Kinase Kinase Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Protein Autophosphorylation Ubiquitin Conjugating Enzyme Activity Lamellipodium Negative Regulation Of Membrane Tubulation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Actin Filament-based Process Regulation Of Protein Modification Process Focal Adhesion Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Modification-dependent Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Proteolysis Involved In Protein Catabolic Process T Cell Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Actin Cytoskeleton Organization Actin Polymerization Or Depolymerization Actomyosin Contractile Ring Assembly JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Apoptotic Process Cell Surface Receptor Signaling Pathway Signal Transduction Protein Polymerization Programmed Cell Death Cell Death Positive Regulation Of Protein Phosphorylation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Cell Communication Protein Modification Process Cytoplasm	Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Enzyme Binding Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Immune System Process Cytosol Protein Phosphorylation Protein Domain Specific Binding Regulation Of Protein Metabolic Process Phosphorylation Maltose Metabolic Process NADPH Oxidase Complex Histone H3T6 Kinase Activity Positive Regulation Of Immune System Process Protein Serine/threonine Kinase Activity Regulation Of Hemopoiesis Regulation Of G1/S Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation Regulation Of Cell Activation Alpha-1,4-glucosidase Activity Superoxide Anion Generation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Positive Regulation Of Leukocyte Differentiation Alpha-glucosidase Activity Phagolysosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Rb-E2F Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport Regulation Of Cell Development Superoxide Metabolic Process Plasma Membrane Extracellular Exosome Response To Hormone Nuclear Matrix Regulation Of Multicellular Organismal Development
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