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SH3RF1 and RAC1
Number of citations of the paper that reports this interaction (PMID
20936779
)
48
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
SH3RF1
RAC1
Gene Name
SH3 domain containing ring finger 1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Apparatus
Cytosol
Lamellipodium
Perinuclear Region Of Cytoplasm
Golgi Membrane
Phagocytic Cup
Cytoplasm
Trans-Golgi Network
Cytosol
Actin Filament
Plasma Membrane
Focal Adhesion
Membrane
Extrinsic Component Of Plasma Membrane
Lamellipodium
Ruffle Membrane
Cytoplasmic Ribonucleoprotein Granule
Melanosome
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Ligase Activity
GTPase Activity
Protein Binding
GTP Binding
Rab GTPase Binding
Enzyme Binding
Protein Kinase Binding
GTP-dependent Protein Binding
Thioesterase Binding
Rho GDP-dissociation Inhibitor Binding
Biological Process
Protein Ubiquitination
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of JNK Cascade
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Auditory Receptor Cell Morphogenesis
Mast Cell Chemotaxis
Epithelial Cell Morphogenesis
Movement Of Cell Or Subcellular Component
Inflammatory Response
Hyperosmotic Response
Cell Adhesion
Cell-matrix Adhesion
G-protein Coupled Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Axon Guidance
Blood Coagulation
Metabolic Process
Cell Proliferation
Response To Wounding
Anatomical Structure Morphogenesis
Regulation Of Hydrogen Peroxide Metabolic Process
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Cell-substrate Adhesion
Viral Process
Cerebral Cortex Radially Oriented Cell Migration
Embryonic Olfactory Bulb Interneuron Precursor Migration
Lamellipodium Assembly
Actin Cytoskeleton Organization
Actin Filament Polymerization
Platelet Activation
Regulation Of Cell Migration
Positive Regulation Of Actin Filament Polymerization
T Cell Costimulation
Ruffle Organization
Negative Regulation Of Interleukin-23 Production
Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Rho Protein Signal Transduction
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Engulfment Of Apoptotic Cell
Innate Immune Response
Cell-cell Junction Organization
Bone Resorption
Positive Regulation Of DNA Replication
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Negative Regulation Of Receptor-mediated Endocytosis
Anatomical Structure Arrangement
Dendrite Morphogenesis
Cell Motility
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Stress Fiber Assembly
Localization Within Membrane
Positive Regulation Of Focal Adhesion Assembly
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Respiratory Burst
Semaphorin-plexin Signaling Pathway
Dopaminergic Neuron Differentiation
Protein Localization To Plasma Membrane
Positive Regulation Of Neutrophil Chemotaxis
Cochlea Morphogenesis
Ruffle Assembly
Apoptotic Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Signaling by GPCR
DCC mediated attractive signaling
FCERI mediated MAPK activation
Signaling by Wnt
Nef and signal transduction
Signaling by SCF-KIT
DAP12 signaling
EPH-Ephrin signaling
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Sema4D induced cell migration and growth-cone collapse
DAP12 interactions
Host Interactions of HIV factors
CD28 co-stimulation
The role of Nef in HIV-1 replication and disease pathogenesis
Factors involved in megakaryocyte development and platelet production
GPCR downstream signaling
Signaling by VEGF
Fc epsilon receptor (FCERI) signaling
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Platelet activation, signaling and aggregation
PCP/CE pathway
Adaptive Immune System
Axon guidance
Costimulation by the CD28 family
HIV Infection
Translocation of GLUT4 to the plasma membrane
L1CAM interactions
VEGFA-VEGFR2 Pathway
EPHB-mediated forward signaling
Inactivation of Cdc42 and Rac
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Activation of Rac
VEGFR2 mediated vascular permeability
Sema4D mediated inhibition of cell attachment and migration
G alpha (12/13) signalling events
Sema4D in semaphorin signaling
Netrin-1 signaling
Innate Immune System
Signalling by NGF
Signal transduction by L1
Cell death signalling via NRAGE, NRIF and NADE
Semaphorin interactions
p75 NTR receptor-mediated signalling
beta-catenin independent WNT signaling
CD28 dependent Vav1 pathway
DSCAM interactions
NRAGE signals death through JNK
GPVI-mediated activation cascade
Signaling by Robo receptor
Drugs
Guanosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions
18 interactors:
ADAM15
AKT1
AKT2
KCNJ1
MAP3K10
MAP3K11
MAP3K12
MAP3K9
MAP4K3
PAK2
PDCD6IP
RAC1
RACGAP1
SEMA6A
SIAH1
UBE2D1
UBE2D3
UBE2N
144 interactors:
ACTA1
ACTB
AKT1
ARFIP2
ARHGAP1
ARHGAP15
ARHGAP17
ARHGAP27
ARHGAP31
ARHGAP32
ARHGAP33
ARHGAP44
ARHGDIA
ARHGDIB
ARHGDIG
ARHGEF2
ARHGEF25
ARHGEF4
ARHGEF7
ARL2BP
BAG6
BAIAP2
BCR
BIRC2
BRINP1
CASP3
CASP7
CAV1
CDC23
CDC42
CDC42BPG
CDC42SE1
CDC42SE2
CFAP36
CHN1
CHN2
CIT
CNTNAP1
COG5
COX3
CSN2
CYBA
CYBB
CYFIP1
DEF6
DIAPH1
DIAPH3
DMPK
DOCK1
DOCK2
DOCK8
DVL1
DVL2
EIF2AK2
FHOD1
FLNA
FMNL1
GRN
HACD3
HPS4
ICMT
IFNGR1
IL1RAP
IQGAP1
IQGAP2
KALRN
KPNA4
KPNA6
KRT40
KTN1
LATS1
LTBP3
LTBP4
LZTS2
MAGI1
MAP3K10
MAP3K11
MAP3K4
MCF2L
MCM3AP
METAP2
MTNR1A
MYD88
MYH9
NCF2
NCK1
NCKAP1
NEDD4
NME1
NOS2
NOXA1
OCRL
OPHN1
PAK1
PAK2
PAK3
PAK7
PARD6A
PARD6B
PARD6G
PARK2
PIAS3
PIK3R1
PIP4K2A
PLD1
PLEKHG2
PLXNB1
PPP2R2B
PRKCA
PRKCD
PRKCI
PRMT6
PTK2
RALBP1
RAP1GDS1
RASGRF1
RCC2
RGL2
RPS6KB1
SET
SFPQ
SH3BP1
SH3RF1
SH3RF3
STAT1
STAT3
STAU1
SUMO2
SYNJ2
TBC1D3F
TIAM1
TLR2
TNFRSF12A
TRIO
TUBA4A
UNKL
USH1C
USP6
VAV1
VAV2
VAV3
VWF
WAS
WASF1
Entrez ID
57630
5879
HPRD ID
15335
03627
Ensembl ID
ENSG00000154447
ENSG00000136238
Uniprot IDs
Q7Z6J0
A4D2P0
A4D2P1
P63000
PDB IDs
1E96
1FOE
1G4U
1HE1
1HH4
1I4D
1I4L
1I4T
1MH1
1RYF
1RYH
2FJU
2H7V
2NZ8
2P2L
2RMK
2VRW
2WKP
2WKQ
2WKR
2YIN
3B13
3BJI
3RYT
3SBD
3SBE
3SU8
3SUA
3TH5
4GZL
4GZM
Enriched GO Terms of Interacting Partners
?
Cell Death
Death
Positive Regulation Of Transferase Activity
Positive Regulation Of Protein Modification Process
Apoptotic Process
Programmed Cell Death
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
JNK Cascade
Protein Autophosphorylation
Signaling
Regulation Of Catalytic Activity
Intracellular Signal Transduction
Cell Communication
Activation Of JNKK Activity
Positive Regulation Of Protein Phosphorylation
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Kinase Activity
Signal Transduction By Phosphorylation
Response To Stress
Signal Transduction
Positive Regulation Of Phosphorylation
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Activation Of MAPKK Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Cellular Protein Modification Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Phosphorylation
Cellular Response To Stress
MAPK Cascade
Regulation Of Signal Transduction
Positive Regulation Of Protein Kinase Activity
Immune Response-regulating Signaling Pathway
Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Innate Immune Response
Cellular Response To Stimulus
Protein Metabolic Process
Peptidyl-serine Phosphorylation
Regulation Of Phosphorylation
Protein Phosphorylation
Regulation Of Signaling
Regulation Of Organelle Organization
Regulation Of Catalytic Activity
Intracellular Signal Transduction
Regulation Of Signal Transduction
Signal Transduction
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Signaling
Cell Communication
Cellular Response To Stimulus
Small GTPase Mediated Signal Transduction
Regulation Of GTPase Activity
Positive Regulation Of Metabolic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Hydrolase Activity
Response To Stimulus
Regulation Of Small GTPase Mediated Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Rho GTPase Activity
Regulation Of Cellular Process
Positive Regulation Of Rho GTPase Activity
Positive Regulation Of Ras GTPase Activity
Regulation Of Ras GTPase Activity
Regulation Of Rho Protein Signal Transduction
Regulation Of Metabolic Process
Positive Regulation Of Rac GTPase Activity
Regulation Of Ras Protein Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Cell Death
Death
Regulation Of Apoptotic Process
Regulation Of Cell Death
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Apoptotic Process
Programmed Cell Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Response To External Stimulus
Positive Regulation Of Cell Death
Innate Immune Response
Cellular Response To Growth Factor Stimulus
Movement Of Cell Or Subcellular Component
Response To Growth Factor
Cell Projection Organization
Cellular Response To Organic Substance
Generation Of Neurons
Tagcloud
?
3t3
activate
bind
chimeric
cytoskeletal
dispensable
effector
effectors
interrelationship
jnk
jun
lamellipodia
lamellipodium
mediate
nh2
nih
p65
pak
ras
rho
rhoa
ruffling
srf
stimulate
surprisingly
threonine
transformation
transforming
tumorigenic
Tagcloud (Difference)
?
3t3
activate
bind
chimeric
cytoskeletal
dispensable
effector
effectors
interrelationship
jnk
jun
lamellipodia
lamellipodium
mediate
nh2
nih
p65
pak
ras
rho
rhoa
ruffling
srf
stimulate
surprisingly
threonine
transformation
transforming
tumorigenic
Tagcloud (Intersection)
?