SH3RF1 and RIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3RF1	RIN1
Description		SH3 domain containing ring finger 1	Ras and Rab interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Lamellipodium Cell Projection Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Endocytic Vesicle
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	MAPK Cascade Neuron Migration Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Response To Aldosterone Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Endocytosis Signal Transduction Vesicle-mediated Transport Intracellular Signal Transduction
Pathways		RHOV GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1	49 interacting genes: ABL1 ABL2 AFDN ANKS1A ANKS1B CALCOCO2 CAPNS2 CARD10 CRACR2B EGFR EIF3F ERBB2 ERBB3 GOLGA2 GOLGA6L9 HMG20A HRAS HSF2BP ITSN1 KLHL12 KRT34 KRTAP13-1 KRTAP15-1 LZTS2 MDFI MTDH PICK1 PLEKHG4 RAB5A RAB5B RALGDS RRAS2 SEC23B SH3RF1 SNX17 SORBS3 SPRED1 TBC1D1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM7 TRIP10 TSC1 YWHAB YWHAE YWHAZ ZBED1
Entrez ID		57630	9610
HPRD ID		15335	05813
Ensembl ID		ENSG00000154447	ENSG00000174791
Uniprot IDs		Q7Z6J0	A0A0S2Z4T5 A0A0S2Z4U0 Q13671
PDB IDs		7NZC 7NZD
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding MAP Kinase Kinase Kinase Activity Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly JUN Kinase Kinase Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Protein Autophosphorylation Ubiquitin Conjugating Enzyme Activity Lamellipodium Negative Regulation Of Membrane Tubulation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Actin Filament-based Process Regulation Of Protein Modification Process Focal Adhesion Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Modification-dependent Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Proteolysis Involved In Protein Catabolic Process T Cell Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Actin Cytoskeleton Organization Actin Polymerization Or Depolymerization Actomyosin Contractile Ring Assembly JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Apoptotic Process Cell Surface Receptor Signaling Pathway Signal Transduction Protein Polymerization Programmed Cell Death Cell Death Positive Regulation Of Protein Phosphorylation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Cell Communication Protein Modification Process Cytoplasm	Cytosol Cytoplasm Perinuclear Region Of Cytoplasm Phosphoserine Residue Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of MAPK Cascade ERBB Signaling Pathway GDP Binding Intracellular Signaling Cassette MAPK Cascade Identical Protein Binding Regulation Of Intracellular Signal Transduction Protein Sequestering Activity ERBB3:ERBB2 Complex Regulation Of Autophagy Melanosome Positive Regulation Of Intracellular Signal Transduction Cellular Localization Vesicle-mediated Transport Schwann Cell Development Protein Tyrosine Kinase Activity Glial Cell Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Establishment Of Protein Localization Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Binding Establishment Of Localization In Cell Regulation Of Cell Communication Signal Transduction Regulation Of Signaling ErbB-3 Class Receptor Binding Regulation Of Cellular Component Organization Intracellular Transport Regulation Of Actin Filament-based Process Protein Binding Regulation Of Establishment Of T Cell Polarity Regulation Of Signal Transduction Protein Modification Process Regulation Of Fibroblast Proliferation Regulation Of ERK1 And ERK2 Cascade Protein Phosphatase Binding Myelination Axon Ensheathment Regulation Of Protein Localization Negative Regulation Of Signaling Negative Regulation Of Cell Communication ERBB2-EGFR Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?