FHL2 and ITGB1

Number of citations of the paper that reports this interaction (PubMedID 10906324)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro)

		FHL2	ITGB1
Description		four and a half LIM domains 2	integrin subunit beta 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Z Disc	Ruffle Cytoplasm Endosome Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Endosome Membrane Intercalated Disc Membrane Lamellipodium Filopodium Cytoplasmic Vesicle Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha4-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha6-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha9-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Integrin Alphav-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Cell Projection Dendritic Spine Receptor Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Anchoring Junction Synaptic Membrane Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding BHLH Transcription Factor Binding Metal Ion Binding	Magnesium Ion Binding Virus Receptor Activity Fibronectin Binding Protease Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Coreceptor Activity Protein Kinase Binding C-X3-C Chemokine Binding Signaling Receptor Activity Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Collagen Binding Involved In Cell-matrix Adhesion Integrin Binding Involved In Cell-matrix Adhesion Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Response To Hormone Negative Regulation Of Apoptotic Process Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade	G1/S Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Angiogenesis In Utero Embryonic Development Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Phagocytosis Cellular Defense Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Neuroblast Proliferation Muscle Organ Development Myoblast Fusion Cell Population Proliferation Germ Cell Migration Visual Learning Regulation Of Collagen Catabolic Process Positive Regulation Of Fibroblast Migration Response To Muscle Activity Cell Migration Formation Of Radial Glial Scaffolds Central Nervous System Neuron Differentiation CD40 Signaling Pathway Cell Projection Organization Lamellipodium Assembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Neuron Projection Development Cell-substrate Adhesion Receptor Internalization Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Wound Healing, Spreading Of Epidermal Cells Maintenance Of Blood-brain Barrier Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of GTPase Activity Sarcomere Organization Myoblast Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Mesodermal Cell Differentiation Myoblast Fate Specification Axon Extension Dendrite Morphogenesis Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Cardiac Cell Fate Specification Regulation Of Biological Quality Cellular Response To Low-density Lipoprotein Particle Stimulus Basement Membrane Organization Positive Regulation Of Wound Healing Cell-cell Adhesion Regulation Of Spontaneous Synaptic Transmission Reactive Gliosis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Synapse Pruning Negative Regulation Of Anoikis
Pathways		PPARA activates gene expression	Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans Other semaphorin interactions Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions CHL1 interactions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen MET activates PTK2 signaling MET interacts with TNS proteins RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle HCMV Early Events GPER1 signaling Potential therapeutics for SARS Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of the ureteric bud Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs			Antithymocyte immunoglobulin (rabbit) MK-0668 PLN-74809
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder x sex interaction ( 34099189) Body fat mass ( 28552196) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) Walking pace ( 33128006)	Depression (quantitative trait) ( 20800221) Suicide in bipolar disorder ( 25917933)
Interacting Genes		175 interacting genes: A1CF ABI1 ABLIM1 ADAM17 AK1 AKIP1 AMOT ANKRD55 APP AR ARHGAP9 ATOSB ATXN1 BANP BARX2 BIN1 BLZF1 BMPR2 BRCA1 CACNA1C CAND2 CAPN1 CARD8 CATSPERT CCDC198 CCDC92 CDC73 CFTR CIMIP1 CKM CREBBP CSK CSN2 CTNNB1 DAPL1 DCP1A DDIT4L DLGAP1 DPF2 DRC4 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FAM204A FHL1 FHL3 FHL5 FOXO1 GATAD2B GLYR1 GMEB2 GNG12 GNG4 GOLGA6A GTF2F2 GTF2H1 HAND1 HCK HSF2BP HSPB2 ID3 IDH1 IER3 IFI35 IGFBP5 IKZF1 IKZF4 IL16 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 KIF5B KLF12 KLHL20 KPRP LDLRAP1 LRIF1 MAGEL2 MBD3L1 MCM7 MDM2 MISP MYBPC1 MYO15B NBPF6 NIBAN1 NRF1 PFKM PHB2 PHF1 PHF21A PKNOX1 PKNOX2 POGZ POU6F2 PRDM11 PRDM6 PRR5L PSEN2 PUF60 QRICH1 RAI2 REL REV1 RFX3 RIPPLY1 RUNX2 SAP30BP SAXO1 SAXO2 SAXO4 SCNM1 SFPQ SH3RF1 SIGLEC6 SLAIN1 SLC34A1 SMAD2 SMAD3 SMAD4 SNAI1 SOX30 SP2 SPRY4 SREBF2 SRF STAT3 SUMO1P1 TCP10L TNFRSF11A TOX3 TRAF6 TRIM55 TRIM63 TRIM73 TTN TXNRD3 VXN WASHC1 WT1 YPEL3 YY1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF143 ZNF200 ZNF212 ZNF23 ZNF3 ZNF331 ZNF408 ZNF410 ZNF417 ZNF620 ZNF626 ZNF638 ZNF655 ZNF85 ZSCAN9	80 interacting genes: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD274 CD36 CD46 CD82 CD9 CD93 COL18A1 CRKL DAG1 DOK1 EGFR ENO1 EPS8 FBLN1 FBXO2 FERMT1 FERMT2 FERMT3 FHL2 FLNA FLNB FLT4 FN1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LAMTOR5 LGALS1 LGALS3BP LGALS8 MAP4K4 MET NCKIPSD NF2 NGF NME1 NMRK2 PDHB PIP5K1C PLAUR PRKCA PRKCE PTK2 PXN RAB25 RACK1 SLC3A2 SPP1 TGM2 TGOLN2 TIMP2 TLN1 TSPAN4 TSPAN7 UPF2 VCAM1 VCAN YWHAB
Entrez ID		2274	3688
HPRD ID		04026	00628
Ensembl ID		ENSG00000115641	ENSG00000150093
Uniprot IDs		Q14192 Q2XQU9 Q6I9R8	P05556
PDB IDs		1X4K 1X4L 2D8Z 2MIU	3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4 7CEB 7CEC 7NWL 7NXD 8RPQ 8W30 9B9J 9B9K 9CKV
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Zinc Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Positive Regulation Of Metabolic Process Transcription Regulator Complex Metal Ion Binding Regulation Of MiRNA Transcription Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-templated Transcription Formation Of Primary Germ Layer Integrin Complex Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex	Integrin Binding Focal Adhesion Cell Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Cell-substrate Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Integrin Complex Regulation Of Cell Motility Regulation Of Locomotion Cell Surface Regulation Of Cell-substrate Adhesion Plasma Membrane Cell Migration Positive Regulation Of Cell-substrate Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Cell Motility Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Anchoring Junction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Extracellular Exosome Signaling Receptor Activity Substrate Adhesion-dependent Cell Spreading Regulation Of Apoptotic Process Membrane Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Communication Cell-substrate Junction Assembly Anatomical Structure Morphogenesis Cell-substrate Junction Organization Integrin Activation Positive Regulation Of Signal Transduction Ruffle Membrane Regulation Of Cellular Component Organization Collagen Binding Involved In Cell-matrix Adhesion Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization
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