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FHL2 and SMAD2
Number of citations of the paper that reports this interaction (PubMedID
19139564
)
40
Data Source:
BioGRID
(pull down, affinity chromatography technology)
FHL2
SMAD2
Description
four and a half LIM domains 2
SMAD family member 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Focal Adhesion
Z Disc
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
SMAD Protein Complex
Homomeric SMAD Protein Complex
Heteromeric SMAD Protein Complex
Molecular Function
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Identical Protein Binding
BHLH Transcription Factor Binding
Metal Ion Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Phosphatase Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
SMAD Binding
Metal Ion Binding
Tau Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Regulation Of Transcription By RNA Polymerase II
Response To Hormone
Negative Regulation Of Apoptotic Process
Atrial Cardiac Muscle Cell Development
Ventricular Cardiac Muscle Cell Development
Heart Trabecula Formation
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Ureteric Bud Development
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Regionalization
Determination Of Left/right Asymmetry In Lateral Mesoderm
Aortic Valve Morphogenesis
Pulmonary Valve Morphogenesis
Endocardial Cushion Morphogenesis
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Transforming Growth Factor Beta Receptor Signaling Pathway
Zygotic Specification Of Dorsal/ventral Axis
Gastrulation
Pattern Specification Process
Endoderm Development
Mesoderm Development
Heart Development
Cell Population Proliferation
Anatomical Structure Morphogenesis
Response To Glucose
Post-embryonic Development
Embryonic Pattern Specification
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Insulin Secretion
Cell Differentiation
Negative Regulation Of Ossification
Lung Development
Positive Regulation Of BMP Signaling Pathway
Pancreas Development
Primary MiRNA Processing
Activin Receptor Signaling Pathway
Organ Growth
Intracellular Signal Transduction
Nodal Signaling Pathway
Cell Fate Commitment
Negative Regulation Of Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Morphogenesis
Developmental Growth
Embryonic Foregut Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Multicellular Organismal Process
Pericardium Development
SMAD Protein Signal Transduction
Mesenchyme Development
Trophoblast Cell Migration
Secondary Palate Development
Response To Cholesterol
Response To Transforming Growth Factor Beta
Odontoblast Differentiation
Pathways
PPARA activates gene expression
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Germ layer formation at gastrulation
Formation of axial mesoderm
Formation of definitive endoderm
Formation of definitive endoderm
Drugs
Dexfosfoserine
Diseases
Colorectal cancer
GWAS
Appendicular lean mass (
33097823
)
Bipolar disorder x sex interaction (
34099189
)
Body fat mass (
28552196
)
Hip circumference adjusted for BMI (
34021172
)
Household income (MTAG) (
31844048
)
Lung cancer in ever smokers (
28604730
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
Walking pace (
33128006
)
Coronary artery disease in type 1 diabetes (
29695241
)
Daytime nap (
33568662
)
Lung cancer in ever smokers (
28604730
)
Menarche (age at onset) (
27182965
)
Interacting Genes
175 interacting genes:
A1CF
ABI1
ABLIM1
ADAM17
AK1
AKIP1
AMOT
ANKRD55
APP
AR
ARHGAP9
ATOSB
ATXN1
BANP
BARX2
BIN1
BLZF1
BMPR2
BRCA1
CACNA1C
CAND2
CAPN1
CARD8
CATSPERT
CCDC198
CCDC92
CDC73
CFTR
CIMIP1
CKM
CREBBP
CSK
CSN2
CTNNB1
DAPL1
DCP1A
DDIT4L
DLGAP1
DPF2
DRC4
DTX2
DUSP10
E2F1
E2F2
E2F3
E2F4
EP300
ESR1
FAM204A
FHL1
FHL3
FHL5
FOXO1
GATAD2B
GLYR1
GMEB2
GNG12
GNG4
GOLGA6A
GTF2F2
GTF2H1
HAND1
HCK
HSF2BP
HSPB2
ID3
IDH1
IER3
IFI35
IGFBP5
IKZF1
IKZF4
IL16
INCA1
ITGA3
ITGA7
ITGB1
ITGB2
ITGB5
ITGB6
JUP
KANK2
KIAA1217
KIF5B
KLF12
KLHL20
KPRP
LDLRAP1
LRIF1
MAGEL2
MBD3L1
MCM7
MDM2
MISP
MYBPC1
MYO15B
NBPF6
NIBAN1
NRF1
PFKM
PHB2
PHF1
PHF21A
PKNOX1
PKNOX2
POGZ
POU6F2
PRDM11
PRDM6
PRR5L
PSEN2
PUF60
QRICH1
RAI2
REL
REV1
RFX3
RIPPLY1
RUNX2
SAP30BP
SAXO1
SAXO2
SAXO4
SCNM1
SFPQ
SH3RF1
SIGLEC6
SLAIN1
SLC34A1
SMAD2
SMAD3
SMAD4
SNAI1
SOX30
SP2
SPRY4
SREBF2
SRF
STAT3
SUMO1P1
TCP10L
TNFRSF11A
TOX3
TRAF6
TRIM55
TRIM63
TRIM73
TTN
TXNRD3
VXN
WASHC1
WT1
YPEL3
YY1
ZBTB16
ZBTB25
ZFP64
ZFYVE9
ZMYM4
ZNF131
ZNF143
ZNF200
ZNF212
ZNF23
ZNF3
ZNF331
ZNF408
ZNF410
ZNF417
ZNF620
ZNF626
ZNF638
ZNF655
ZNF85
ZSCAN9
220 interacting genes:
ABTB1
ACVR1B
AFDN
AKT1
ANAPC10
ANAPC2
ANK3
ANP32B
ANP32E
ANTXR2
AP1B1
ARFGAP3
ARHGEF6
ARL4D
ATP5ME
AXIN1
BAZ1A
BECN1
BPTF
BRCA1
BTBD2
C22orf46P
CAMK2A
CAMK2G
CDC16
CDC27
CDC40
CDK2
CDK4
CDK8
CDK9
CISH
COPS5
CORO2A
CREBBP
CSH1
CSH2
CSNK1D
CTNNB1
CUL5
CYLC2
CYP11A1
DAB2
DCAF6
DCUN1D1
DENND2B
DNAJB5
DNAJC7
DOCK8
DVL1
DYNC1H1
DYRK1A
E2F4
EEF1A1
EID2
EIF3L
ELAC2
EP300
ERBIN
ESR1
ESR2
FAM161B
FBN2
FBP2
FHL2
FHL3
FOXG1
FOXH1
FOXO3
GATAD2B
GFER
GLI3
GRIPAP1
GSC
GTF2I
HDAC1
HDAC2
HGS
HIPK2
HNF4A
HOXA13
HOXA9
HOXD13
HSD17B3
HUWE1
HYAL2
INSR
IRAK2
ITCH
JUN
KAT2B
KHDRBS1
KPNB1
LAMA5
LATS2
LCK
LEF1
LEMD3
LHX9
LITAF
LMO2
MAP2K1
MAPK1
MAPK3
MAPK8
MAPK9
MECOM
MED15
MED6
MEF2A
MEF2C
MYC
MYOCD
NAGK
NCOA6
NEDD4L
NEDD9
NEFM
NFIA
NFYC
NOTCH4
NUAK2
NUP153
NUP214
OS9
OTUB1
PAK1
PAPOLA
PAPPA
PARD3
PAXIP1
PEX19
PIAS3
PIAS4
PIK3CA
PLIN3
POU2AF1
PPM1A
PPP2R1A
PRKAR1A
PSAP
PSG9
PSMD11
PSMD8
PTMS
RAB34
RAB38
RAN
RANBP6
RANBP9
RARB
RASA1
RASD2
RASL12
RBL1
RHEBL1
RHOA
RHOD
RHOJ
RIT1
RNF123
RNPC3
ROCK1
RPS14
RPS27A
RUNX2
RXRA
SKI
SKIL
SKOR2
SMAD1
SMAD3
SMAD4
SMAD7
SMAD9
SMURF1
SMURF2
SNAPIN
SNIP1
SNRNP70
SNW1
SOD1
SP1
SQSTM1
SRI
ST13
STAG1
STAMBP
STAMBPL1
STRAP
STUB1
SYT1
TBC1D1
TGFBR1
TGFBRAP1
TGIF1
TGM2
TNNT1
TOB1
TP53
TP73
TRIM62
TRMO
TSC2
TUBA1B
UBA52
UBR5
UCHL5
USP9X
WASHC4
XPA
YY1
ZEB1
ZEB2
ZFYVE9
ZMYND11
ZNF41
ZNF510
ZNF8
ZNHIT6
Entrez ID
2274
4087
HPRD ID
04026
03221
Ensembl ID
ENSG00000115641
ENSG00000175387
Uniprot IDs
Q14192
Q2XQU9
Q6I9R8
B7Z5N5
Q15796
Q53XR6
PDB IDs
1X4K
1X4L
2D8Z
2MIU
1DEV
1KHX
1U7V
2LB3
5XOD
5ZOJ
6H3R
6M64
6YIA
6ZVQ
7CO1
Enriched GO Terms of Interacting Partners
?
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Binding
Negative Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Negative Regulation Of RNA Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Activity
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Protein Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Positive Regulation Of Macromolecule Metabolic Process
Sequence-specific DNA Binding
Zinc Ion Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
Positive Regulation Of Metabolic Process
Transcription Regulator Complex
Metal Ion Binding
Regulation Of MiRNA Transcription
Sequence-specific Double-stranded DNA Binding
Chromatin
Regulation Of MiRNA Metabolic Process
Nucleoplasm
DNA-templated Transcription
Formation Of Primary Germ Layer
Integrin Complex
Transcription By RNA Polymerase II
RNA Polymerase II Transcription Regulator Complex
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleoplasm
SMAD Binding
Regulation Of Signal Transduction
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Transcription Regulator Complex
Regulation Of Primary Metabolic Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Communication
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Signaling
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Developmental Process
Positive Regulation Of Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Intracellular Signal Transduction
Chromatin
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Enzyme-linked Receptor Protein Signaling Pathway
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
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Tagcloud (Intersection)
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