SH3RF1 and MAP4K3

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		SH3RF1	MAP4K3
Gene Name		SH3 domain containing ring finger 1	mitogen-activated protein kinase kinase kinase kinase 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm	Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of JNK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Phosphorylation JNK Cascade Response To UV Response To Tumor Necrosis Factor Intracellular Signal Transduction Regulation Of Catalytic Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ADAM15 AKT1 AKT2 KCNJ1 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 PAK2 PDCD6IP RAC1 RACGAP1 SEMA6A SIAH1 UBE2D1 UBE2D3 UBE2N	7 interactors: BIN1 COPS5 GRB2 ITSN2 SH3GL2 SH3RF1 SORBS1
Entrez ID		57630	8491
HPRD ID		15335	05373
Ensembl ID		ENSG00000154447	ENSG00000011566
Uniprot IDs		Q7Z6J0	A8K602 B3KMM5 Q8IVH8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Death Death Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Apoptotic Process Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Signaling Regulation Of Catalytic Activity Intracellular Signal Transduction Cell Communication Activation Of JNKK Activity Positive Regulation Of Protein Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Signal Transduction By Phosphorylation Response To Stress Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Cellular Response To Stress MAPK Cascade Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Stimulus Protein Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Signaling Regulation Of Organelle Organization	Vesicle-mediated Transport Regulation Of Signal Transduction Endocytosis Regulation Of Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Metabolic Process Transport Regulation Of MAPK Cascade Lipid Tube Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of JNK Cascade ERBB Signaling Pathway Positive Regulation Of Metabolic Process Exosomal Secretion Regulation Of Stress-activated MAPK Cascade Regulation Of Endocytosis Regulation Of Cellular Component Organization Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Cullin Deneddylation Negative Regulation Of Signal Transduction Positive Regulation Of Astrocyte Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Response To Insulin Protein Deneddylation Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Glycogen Biosynthetic Process Stress Fiber Assembly Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Vesicle-mediated Transport Protein-lipid Complex Assembly Axon Guidance Labyrinthine Layer Morphogenesis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Response To Peptide Hormone Cellular Response To Organonitrogen Compound Positive Regulation Of Protein Localization To Plasma Membrane Generation Of Neurons
Tagcloud ?			candidates drosophila hepg2 highlight hippo mammals mcf7 mediating modulators mst mst1 mst3 mtor mtorc1 pak1 rapamycin salvador slk sought sterile stk stk25 stk39 stradalpha talk tao2 taz tead1 yap1
Tagcloud (Difference) ?			candidates drosophila hepg2 highlight hippo mammals mcf7 mediating modulators mst mst1 mst3 mtor mtorc1 pak1 rapamycin salvador slk sought sterile stk stk25 stk39 stradalpha talk tao2 taz tead1 yap1
Tagcloud (Intersection) ?