FHL2 and TRAF6

Number of citations of the paper that reports this interaction (PMID 16184196)
18

Data Source:
HPRD (in vivo)

		FHL2	TRAF6
Gene Name		four and a half LIM domains 2	TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Focal Adhesion Actin Cytoskeleton Z Disc M Band	Nucleus Nucleolus Cytoplasm Mitochondrion Lipid Particle Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane CD40 Receptor Complex Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding Androgen Receptor Binding	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Histone Deacetylase Binding Protein Kinase B Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription, DNA-templated Response To Hormone Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Protein Polyubiquitination Ossification Neural Tube Closure Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Complex Assembly I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Osteoclast Differentiation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein Ubiquitination Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-2 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Cell Development Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Protein Autoubiquitination Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	NF-kB is activated and signals survival TRAF6 mediated induction of TAK1 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation IRAK1 recruits IKK complex Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex activated TAK1 mediates p38 MAPK activation Regulated proteolysis of p75NTR IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex Downstream TCR signaling p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane p75NTR signals via NF-kB MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS
Protein-Protein Interactions		92 interactors: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EIF6 EP300 ESR1 FAM129A FAM154A FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HIF1A ID3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MYBPC1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638	144 interactors: ABL1 APP ATM ATP6V1E1 ATXN3 BECN1 BMPR1B CALCOCO2 CASP8 CAV1 CBL CD40 CYLD ECSIT EDA2R EDARADD FHL2 FYN GTF2I HIF1A HSPA4 IKBKG IL17RB IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MAVS MBP MCL1 MEOX2 MTOR NGFR NGFRAP1 NTRK1 NTRK2 NUMBL OTUB1 OTUB2 OTUD7B PELI3 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RIPK2 RNF114 SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STRADB STUB1 SYK TAB1 TAB2 TAB3 TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIRAP TLR3 TMEM189-UBE2V1 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 UBB UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UEVLD USP1 USP15 USP2 USP21 USP39 USP4 USP5 USP7 VPS52 XIAP YBX1 YES1 ZFAND5 ZMYND11 ZNF675 ZRANB1
Entrez ID		2274	7189
HPRD ID		04026	03833
Ensembl ID		ENSG00000115641
Uniprot IDs		J3KNW4 Q14192 Q2XQU9 Q6I9R8	Q9Y4K3
PDB IDs		1X4K 1X4L 2D8Z	1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Transcription, DNA-templated Formation Of Primary Germ Layer Negative Regulation Of Cellular Metabolic Process Tissue Development Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gastrulation Regulation Of Signaling Anatomical Structure Development Response To Organic Substance Organ Morphogenesis Embryonic Morphogenesis	Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Protein Modification Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Cell Communication Signal Transduction Signaling Immune System Process Activation Of Innate Immune Response Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Innate Immune Response Response To Stimulus Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Response To Organic Substance Cell Death Death Cellular Protein Metabolic Process Innate Immune Response Activation Of Protein Kinase Activity Programmed Cell Death Cellular Response To Organic Substance Cellular Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process
Tagcloud ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf5 transduction
Tagcloud (Difference) ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf5 transduction
Tagcloud (Intersection) ?