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SH3RF1 and AKT2
Number of citations of the paper that reports this interaction (PubMedID
14504284
)
0
Data Source:
HPRD
(in vitro, two hybrid)
SH3RF1
AKT2
Description
SH3 domain containing ring finger 1
AKT serine/threonine kinase 2
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Cytosol
Lamellipodium
Cell Projection
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Ruffle Membrane
Molecular Function
MAP-kinase Scaffold Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Molecular Function Activator Activity
Biological Process
MAPK Cascade
Neuron Migration
Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of JNK Cascade
Protein Autoubiquitination
Response To Aldosterone
Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Glycogen Metabolic Process
Glycogen Biosynthetic Process
Glucose Metabolic Process
Regulation Of Translation
Apoptotic Process
Signal Transduction
Insulin Receptor Signaling Pathway
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Positive Regulation Of Glucose Metabolic Process
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Fatty Acid Beta-oxidation
Peripheral Nervous System Myelin Maintenance
Cellular Response To Insulin Stimulus
Intracellular Signal Transduction
Protein Modification Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Fat Cell Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of D-glucose Import
Protein Stabilization
Regulation Of Cell Cycle
Mammary Gland Epithelial Cell Differentiation
Cellular Response To High Light Intensity
Protein Localization To Plasma Membrane
Positive Regulation Of Protein Targeting To Membrane
Retinal Rod Cell Apoptotic Process
Positive Regulation Of Cap-dependent Translational Initiation
Negative Regulation Of PERK-mediated Unfolded Protein Response
Positive Regulation Of Cell Motility
Pathways
RHOV GTPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Activation of BAD and translocation to mitochondria
PIP3 activates AKT signaling
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Activation of AKT2
PDE3B signalling
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
Co-inhibition by CTLA4
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
RUNX2 regulates genes involved in cell migration
Regulation of PTEN stability and activity
FLT3 Signaling
Regulation of localization of FOXO transcription factors
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
KEAP1-NFE2L2 pathway
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
Ovarian cancer
Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
GWAS
Alzheimer disease and age of onset (
26830138
)
Body fat mass (
28552196
)
Body mass index (
28552196
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Daytime nap (
33568662
)
Night sleep phenotypes (
27126917
)
Photic sneeze reflex (
27182965
)
Schizophrenia (
30285260
)
Weight (
28552196
)
Birth weight (
31043758
)
Cerebrospinal fluid t-tau:AB1-42 ratio (
26252872
)
Cerebrospinal T-tau levels (
26252872
)
Diastolic blood pressure (
28739976
)
Lean body mass (
28552196
)
Lymphocyte count (
32888494
)
Interacting Genes
69 interacting genes:
ACAP1
ADAM15
AKT1
AKT2
ARHGEF15
ATN1
ATXN7L2
CBLB
CCDC6
DLGAP4
DMRTB1
DNM2
EAF1
EVL
FGD1
FHL2
GGN
HERPUD1
KCNJ1
LCP2
MAP3K10
MAP3K11
MAP3K12
MAP3K9
MAP4K3
MTURN
NAF1
NCF1
NFKBID
NHSL2
NUTM2F
ONECUT3
PAK2
PDCD6IP
PRAM1
PRB3
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PXN
RAC1
RACGAP1
RAD23A
RIN1
RNF208
RUNX1T1
SEMA6A
SF3A2
SH2D4A
SH3BP2
SH3D19
SIAH1
SLC22A5
SOCS7
SORBS2
SUFU
SYNPO2L
TP53BP2
UBASH3A
UBE2D1
UBE2D3
UBE2K
UBE2N
VPS37C
WASL
WIPF1
XIRP1
43 interacting genes:
ABCG8
AKT1
AKT1S1
APOA1
APOB
APP
APPL1
BLVRA
CCL14
CDKN1A
CHUK
CLIP3
ESR1
FOXO4
FSHR
GSK3B
H3C1
HSP90AA1
MEOX2
MTCP1
NAMPT
PDPK1
PICK1
PIP5K1C
PLEKHO1
PNPLA3
POFUT1
POLR1B
PRKDC
RAB3D
REL
SH3RF1
SLC2A4
SORBS2
SORBS3
SPRR2A
STEAP4
TCL1A
TCL1B
TMED2
TRIB3
TSC2
XIAP
Entrez ID
57630
208
HPRD ID
15335
01262
Ensembl ID
ENSG00000154447
ENSG00000105221
Uniprot IDs
Q7Z6J0
B4DG79
P31751
PDB IDs
7NZC
7NZD
1GZK
1GZN
1GZO
1MRV
1MRY
1O6K
1O6L
1P6S
2JDO
2JDR
2UW9
2X39
2XH5
3D0E
3E87
3E88
3E8D
8Q61
9C1W
Enriched GO Terms of Interacting Partners
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SH3 Domain Binding
MAP Kinase Kinase Kinase Activity
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
JUN Kinase Kinase Kinase Activity
Positive Regulation Of Actin Filament Bundle Assembly
Protein Autophosphorylation
Ubiquitin Conjugating Enzyme Activity
Lamellipodium
Negative Regulation Of Membrane Tubulation
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Actin Filament-based Process
Regulation Of Protein Modification Process
Focal Adhesion
Ubiquitin-dependent Protein Catabolic Process
Protein Serine Kinase Activity
Modification-dependent Protein Catabolic Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Proteolysis Involved In Protein Catabolic Process
T Cell Receptor Signaling Pathway
Ubiquitin-protein Transferase Activity
Actin Cytoskeleton Organization
Actin Polymerization Or Depolymerization
Actomyosin Contractile Ring Assembly
JNK Cascade
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Regulation Of Signal Transduction
Protein Serine/threonine Kinase Activity
Apoptotic Process
Cell Surface Receptor Signaling Pathway
Signal Transduction
Protein Polymerization
Programmed Cell Death
Cell Death
Positive Regulation Of Protein Phosphorylation
Antigen Receptor-mediated Signaling Pathway
Negative Regulation Of Fatty Acid Transport
Regulation Of Long-chain Fatty Acid Import Into Cell
Peripheral Nervous System Myelin Maintenance
Protein Phosphorylation
Cytoskeleton Organization
Positive Regulation Of Phosphorylation
Regulation Of Signaling
Immune Response-activating Signaling Pathway
Regulation Of Cell Communication
Protein Modification Process
Cytoplasm
Intracellular Signal Transduction
Signal Transduction
Regulation Of Intracellular Signal Transduction
Insulin Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Response To Hormone
Positive Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Nitric-oxide Synthase Regulator Activity
Intracellular Signaling Cassette
Regulation Of Innate Immune Response
Cytosol
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Hormone Stimulus
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Toll-like Receptor Signaling Pathway
Response To Insulin
Positive Regulation Of Nitric Oxide Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Chemical Homeostasis
Low-density Lipoprotein Particle
Regulation Of Vesicle-mediated Transport
Cellular Response To Oxygen-containing Compound
Cellular Response To Amyloid-beta
Homeostatic Process
Response To Peptide Hormone
Endocytic Vesicle Lumen
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Protein Catabolic Process
Protein Kinase Binding
Regulation Of Nitric Oxide Biosynthetic Process
Very-low-density Lipoprotein Particle
Response To Amyloid-beta
Regulation Of Immune System Process
Response To Stress
Positive Regulation Of Signal Transduction
Regulation Of Nitric Oxide Metabolic Process
Response To Nutrient Levels
Regulation Of Protein Modification Process
Protein Serine/threonine Kinase Binding
Cholesterol Transfer Activity
Regulation Of Defense Response
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Tagcloud (Intersection)
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