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SH3RF1 and AKT2
Number of citations of the paper that reports this interaction (PMID
14504284
)
16
Data Source:
HPRD
(two hybrid, in vitro)
SH3RF1
AKT2
Gene Name
SH3 domain containing ring finger 1
v-akt murine thymoma viral oncogene homolog 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Apparatus
Cytosol
Lamellipodium
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Cell Cortex
Ruffle Membrane
Molecular Function
Protein Binding
Zinc Ion Binding
Ligase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Biological Process
Protein Ubiquitination
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of JNK Cascade
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Glycogen Biosynthetic Process
Glucose Metabolic Process
Regulation Of Translation
Cellular Protein Modification Process
Protein Phosphorylation
Apoptotic Process
Signal Transduction
Insulin Receptor Signaling Pathway
Carbohydrate Transport
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Positive Regulation Of Glucose Metabolic Process
Regulation Of Cell Migration
Positive Regulation Of Vesicle Fusion
Positive Regulation Of Fatty Acid Beta-oxidation
Peripheral Nervous System Myelin Maintenance
Activation Of Ral GTPase Activity
Cellular Response To Insulin Stimulus
Fat Cell Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Glucose Import
Mammary Gland Epithelial Cell Differentiation
Membrane Organization
Intracellular Protein Transmembrane Transport
Regulation Of Cell Cycle Arrest
Protein Localization To Plasma Membrane
Positive Regulation Of Protein Targeting To Membrane
Positive Regulation Of Cell Motility
Positive Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Signaling by FGFR in disease
Activation of BH3-only proteins
mTOR signalling
Signaling by Wnt
Activation of PKB
Signaling by EGFRvIII in Cancer
AKT phosphorylates targets in the cytosol
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
Regulation of beta-cell development
PI3K/AKT activation
PI-3K cascade
RNF mutants show enhanced WNT signaling and proliferation
PDE3B signalling
PKB-mediated events
PI3K Cascade
Signaling by PDGF
Downregulation of ERBB2:ERBB3 signaling
DAP12 interactions
GAB1 signalosome
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
G-protein beta:gamma signalling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
PDE3B signalling
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
Signaling by ERBB2
Activation of BAD and translocation to mitochondria
Signaling by EGFR
GPCR downstream signaling
Signaling by VEGF
AKT phosphorylates targets in the nucleus
Downstream signal transduction
Regulation of gene expression in beta cells
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
PI3K/AKT Signaling in Cancer
Platelet activation, signaling and aggregation
Adaptive Immune System
Inhibition of TSC complex formation by PKB
Activation of PKB
Costimulation by the CD28 family
IRS-mediated signalling
PIP3 activates AKT signaling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
IGF1R signaling cascade
deactivation of the beta-catenin transactivating complex
VEGFA-VEGFR2 Pathway
IRS-related events triggered by IGF1R
G beta:gamma signalling through PI3Kgamma
PI3K events in ERBB2 signaling
VEGFR2 mediated vascular permeability
Downstream signaling of activated FGFR
Programmed Cell Death
XAV939 inhibits tankyrase, stabilizing AXIN
Intrinsic Pathway for Apoptosis
Signaling by Insulin receptor
Innate Immune System
Signalling by NGF
Insulin receptor signalling cascade
CTLA4 inhibitory signaling
AKT-mediated inactivation of FOXO1A
Signaling by Ligand-Responsive EGFR Variants in Cancer
IRS-related events
NGF signalling via TRKA from the plasma membrane
Negative regulation of the PI3K/AKT network
Signaling by Overexpressed Wild-Type EGFR in Cancer
Inhibition of TSC complex formation by PKB
Signaling by FGFR
IRS-mediated signalling
TCF dependent signaling in response to WNT
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
GPVI-mediated activation cascade
Signaling by WNT in cancer
PKB-mediated events
PI3K Cascade
Drugs
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
GWAS
Protein-Protein Interactions
18 interactors:
ADAM15
AKT1
AKT2
KCNJ1
MAP3K10
MAP3K11
MAP3K12
MAP3K9
MAP4K3
PAK2
PDCD6IP
RAC1
RACGAP1
SEMA6A
SIAH1
UBE2D1
UBE2D3
UBE2N
38 interactors:
ABCG8
AKT1
AKT1S1
APOA1
APOB
APP
APPL1
CCL14
CHUK
CLIP3
ESR1
FOXO4
FSHR
GSK3B
HIST1H3A
HSP90AA1
MAP3K5
MTCP1
NAMPT
PDPK1
PLEKHO1
PNPLA3
POFUT1
POLR1B
PRKDC
RAB3D
SH3RF1
SLC2A4
SNX27
SORBS2
SPRR2A
STEAP4
TCL1A
TCL1B
TMED2
TRIB3
TSC2
XIAP
Entrez ID
57630
208
HPRD ID
15335
01262
Ensembl ID
ENSG00000154447
ENSG00000105221
Uniprot IDs
Q7Z6J0
B4DG79
P31751
PDB IDs
1GZK
1GZN
1GZO
1MRV
1MRY
1O6K
1O6L
1P6S
2JDO
2JDR
2UW9
2X39
2XH5
3D0E
3E87
3E88
3E8D
Enriched GO Terms of Interacting Partners
?
Cell Death
Death
Positive Regulation Of Transferase Activity
Positive Regulation Of Protein Modification Process
Apoptotic Process
Programmed Cell Death
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
JNK Cascade
Protein Autophosphorylation
Signaling
Regulation Of Catalytic Activity
Intracellular Signal Transduction
Cell Communication
Activation Of JNKK Activity
Positive Regulation Of Protein Phosphorylation
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Kinase Activity
Signal Transduction By Phosphorylation
Response To Stress
Signal Transduction
Positive Regulation Of Phosphorylation
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Activation Of MAPKK Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Cellular Protein Modification Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Phosphorylation
Cellular Response To Stress
MAPK Cascade
Regulation Of Signal Transduction
Positive Regulation Of Protein Kinase Activity
Immune Response-regulating Signaling Pathway
Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Innate Immune Response
Cellular Response To Stimulus
Protein Metabolic Process
Peptidyl-serine Phosphorylation
Regulation Of Phosphorylation
Protein Phosphorylation
Regulation Of Signaling
Regulation Of Organelle Organization
Phosphatidylinositol-mediated Signaling
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fc Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Cellular Response To Insulin Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Innate Immune Response
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cellular Response To Hormone Stimulus
Response To Insulin
Negative Regulation Of Catalytic Activity
Cellular Response To Peptide Hormone Stimulus
Immune Response-regulating Signaling Pathway
Immune Response
Cellular Response To Peptide
Regulation Of Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Apoptotic Signaling Pathway
Response To Hormone
Insulin Receptor Signaling Pathway
Immune System Process
Response To Organic Substance
Negative Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Regulation Of Protein Phosphorylation
Response To Peptide Hormone
Defense Response
Response To Abiotic Stimulus
Chemical Homeostasis
Negative Regulation Of Protein Phosphorylation
Cellular Response To Organonitrogen Compound
Signal Transduction
Regulation Of Establishment Of Protein Localization To Plasma Membrane
Negative Regulation Of Protein Metabolic Process
Response To Peptide
Enzyme Linked Receptor Protein Signaling Pathway
Negative Regulation Of Protein Kinase Activity
Regulation Of Phosphorus Metabolic Process
Apoptotic Process
Cellular Response To Stimulus
Negative Regulation Of Kinase Activity
Regulation Of Protein Localization To Plasma Membrane
Programmed Cell Death
Cellular Response To Organic Substance
Tagcloud
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Difference)
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Intersection)
?