SH3RF1 and KCNJ1

Number of citations of the paper that reports this interaction (PMID 19710010)
9

Data Source:
BioGRID (enzymatic study)

		SH3RF1	KCNJ1
Gene Name		SH3 domain containing ring finger 1	potassium channel, inwardly rectifying subfamily J, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm	Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity	Inward Rectifier Potassium Channel Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP-activated Inward Rectifier Potassium Channel Activity
	Biological Process	Protein Ubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of JNK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Kidney Development Tissue Homeostasis Potassium Ion Transport Synaptic Transmission Excretion Post-embryonic Development Potassium Ion Import Regulation Of Ion Transmembrane Transport Renal Sodium Ion Absorption Cardiovascular System Development Regulation Of G-protein Activated Inward Rectifier Potassium Channel Activity
Pathways			Inwardly rectifying K+ channels Potassium transport channels Potassium Channels
Drugs			Bethanidine Glimepiride Minoxidil Acetohexamide Tolazamide Glyburide Tolbutamide Glycodiazine Agmatine
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ADAM15 AKT1 AKT2 KCNJ1 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 PAK2 PDCD6IP RAC1 RACGAP1 SEMA6A SIAH1 UBE2D1 UBE2D3 UBE2N	8 interactors: GOLGA3 IL16 PRKCD SGK1 SH3RF1 SLC9A3R1 SLC9A3R2 UBC
Entrez ID		57630	3758
HPRD ID		15335	08981
Ensembl ID		ENSG00000154447	ENSG00000151704
Uniprot IDs		Q7Z6J0	A8K432 P48048
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Death Death Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Apoptotic Process Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Signaling Regulation Of Catalytic Activity Intracellular Signal Transduction Cell Communication Activation Of JNKK Activity Positive Regulation Of Protein Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Signal Transduction By Phosphorylation Response To Stress Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Cellular Response To Stress MAPK Cascade Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Stimulus Protein Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Signaling Regulation Of Organelle Organization	Renal Sodium Ion Transport Renal Absorption Negative Regulation Of Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Transporter Activity Apoptotic Process Programmed Cell Death Cell Death Death Negative Regulation Of Intracellular Signal Transduction Renal Phosphate Ion Absorption Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Catalytic Activity Renal System Process Regulation Of Phosphorylation Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Phospholipid Catabolic Process Glutathione Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Death Regulation Of Signal Transduction Interleukin-10 Production Regulation Of Locomotion Negative Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Renal Sodium Ion Absorption Negative Regulation Of Filopodium Assembly Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Regulation Of Protein Kinase Activity Interleukin-12 Production Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Catalytic Activity Response To Fibroblast Growth Factor Regulation Of Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Cellular Phosphate Ion Homeostasis Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Sodium:proton Antiporter Activity
Tagcloud ?			2cl a198t ante antenatal ascending ba2 bartter cdnas cos cotransport currents d108h henle infrequently inwardly kir mg2 p110l potassium reabsorption rectifying romk romk1 salt talh v315g v72e wasting wildtype
Tagcloud (Difference) ?			2cl a198t ante antenatal ascending ba2 bartter cdnas cos cotransport currents d108h henle infrequently inwardly kir mg2 p110l potassium reabsorption rectifying romk romk1 salt talh v315g v72e wasting wildtype
Tagcloud (Intersection) ?