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SH3RF1 and MAP3K12
Number of citations of the paper that reports this interaction (PMID
14504284
)
16
Data Source:
HPRD
(in vitro)
SH3RF1
MAP3K12
Gene Name
SH3 domain containing ring finger 1
mitogen-activated protein kinase kinase kinase 12
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Apparatus
Cytosol
Lamellipodium
Perinuclear Region Of Cytoplasm
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Axon
Growth Cone
Molecular Function
Protein Binding
Zinc Ion Binding
Ligase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Homodimerization Activity
Biological Process
Protein Ubiquitination
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of JNK Cascade
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Activation Of MAPKK Activity
Protein Phosphorylation
JNK Cascade
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Intracellular Signal Transduction
Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
18 interactors:
ADAM15
AKT1
AKT2
KCNJ1
MAP3K10
MAP3K11
MAP3K12
MAP3K9
MAP4K3
PAK2
PDCD6IP
RAC1
RACGAP1
SEMA6A
SIAH1
UBE2D1
UBE2D3
UBE2N
15 interactors:
EGFR
FRA10AC1
FTL
MAP2K4
MAP2K7
MAP3K11
MAPK6
MAPK8IP1
MAPK8IP2
MBIP
RGS1
RPL18A
SH3RF1
TGM2
TSC22D1
Entrez ID
57630
7786
HPRD ID
15335
02709
Ensembl ID
ENSG00000154447
ENSG00000139625
Uniprot IDs
Q7Z6J0
Q12852
PDB IDs
Enriched GO Terms of Interacting Partners
?
Cell Death
Death
Positive Regulation Of Transferase Activity
Positive Regulation Of Protein Modification Process
Apoptotic Process
Programmed Cell Death
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
JNK Cascade
Protein Autophosphorylation
Signaling
Regulation Of Catalytic Activity
Intracellular Signal Transduction
Cell Communication
Activation Of JNKK Activity
Positive Regulation Of Protein Phosphorylation
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Kinase Activity
Signal Transduction By Phosphorylation
Response To Stress
Signal Transduction
Positive Regulation Of Phosphorylation
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Activation Of MAPKK Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Cellular Protein Modification Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Phosphorylation
Cellular Response To Stress
MAPK Cascade
Regulation Of Signal Transduction
Positive Regulation Of Protein Kinase Activity
Immune Response-regulating Signaling Pathway
Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Innate Immune Response
Cellular Response To Stimulus
Protein Metabolic Process
Peptidyl-serine Phosphorylation
Regulation Of Phosphorylation
Protein Phosphorylation
Regulation Of Signaling
Regulation Of Organelle Organization
MAPK Cascade
Signal Transduction By Phosphorylation
Regulation Of JNK Cascade
Regulation Of MAPK Cascade
Regulation Of Stress-activated MAPK Cascade
JNK Cascade
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Regulation Of MAP Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Kinase Activity
Regulation Of JUN Kinase Activity
Regulation Of Phosphorylation
Regulation Of Signal Transduction
Regulation Of Apoptotic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Cell Death
Regulation Of Signaling
Regulation Of Protein Phosphorylation
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Catalytic Activity
Activation Of JUN Kinase Activity
Cellular Response To Sorbitol
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Kinase Activity
Peptidyl-amino Acid Modification
Regulation Of Protein Metabolic Process
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Neuron Death
Positive Regulation Of Transferase Activity
Positive Regulation Of Apoptotic Process
Activation Of Protein Kinase Activity
Positive Regulation Of Programmed Cell Death
Cellular Protein Modification Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Death
Cellular Protein Metabolic Process
Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of JNK Cascade
Tagcloud
?
adipocytes
adipogenesis
adipogenic
adipose
ascs
bisphenol
bpa
ccaat
cebpa
disrupter
dlk
dye
ebpalpha
esr1
ici
igf1
leucine
lipase
lpl
peroxisome
physiologically
pparg
ppargamma
precursors
proliferator
retained
temporally
visualize
zipper
Tagcloud (Difference)
?
adipocytes
adipogenesis
adipogenic
adipose
ascs
bisphenol
bpa
ccaat
cebpa
disrupter
dlk
dye
ebpalpha
esr1
ici
igf1
leucine
lipase
lpl
peroxisome
physiologically
pparg
ppargamma
precursors
proliferator
retained
temporally
visualize
zipper
Tagcloud (Intersection)
?