SH3RF1 and FGD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3RF1	FGD1
Description		SH3 domain containing ring finger 1	FYVE, RhoGEF and PH domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Lamellipodium Cell Projection Perinuclear Region Of Cytoplasm	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Lamellipodium Cell Projection
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Guanyl-nucleotide Exchange Factor Activity Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	MAPK Cascade Neuron Migration Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Response To Aldosterone Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cytoskeleton Organization Signal Transduction Regulation Of Cell Shape Animal Organ Morphogenesis Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHOV GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation	NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle
Drugs
Diseases			Aarskog-Scott syndrome; Faciogenital dysplasia
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Prostate cancer ( 31562322)
Interacting Genes		69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1	5 interacting genes: AOC1 CDC42 CTTN ELMO1 SH3RF1
Entrez ID		57630	2245
HPRD ID		15335	02373
Ensembl ID		ENSG00000154447	ENSG00000102302
Uniprot IDs		Q7Z6J0	P98174
PDB IDs		7NZC 7NZD
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding MAP Kinase Kinase Kinase Activity Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly JUN Kinase Kinase Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Protein Autophosphorylation Ubiquitin Conjugating Enzyme Activity Lamellipodium Negative Regulation Of Membrane Tubulation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Actin Filament-based Process Regulation Of Protein Modification Process Focal Adhesion Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Modification-dependent Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Proteolysis Involved In Protein Catabolic Process T Cell Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Actin Cytoskeleton Organization Actin Polymerization Or Depolymerization Actomyosin Contractile Ring Assembly JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Apoptotic Process Cell Surface Receptor Signaling Pathway Signal Transduction Protein Polymerization Programmed Cell Death Cell Death Positive Regulation Of Protein Phosphorylation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Cell Communication Protein Modification Process Cytoplasm	Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Phagocytosis, Engulfment Membrane Invagination Cell Motility Postsynapse Actin Cytoskeleton Organization Actin Filament-based Process Endocytosis Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Glutamatergic Synapse Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Import Into Cell GBD Domain Binding Storage Vacuole Regulation Of Postsynapse Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Apolipoprotein A-I Receptor Binding Intracellular Signaling Cassette Neuropilin Signaling Pathway Positive Regulation Of Cytoskeleton Organization Lamellipodium Quinone Binding Primary Methylamine Oxidase Activity Putrescine Metabolic Process Leading Edge Membrane Regulation Of Cell Projection Assembly Thioesterase Binding Cell Projection Morphogenesis Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Actin Filament Organization Vesicle-mediated Transport Actin Filament Organization Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cell Junction Assembly Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Neuron Projection Morphogenesis Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Profilin Binding
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