FHL2 and SLC34A1

Number of citations of the paper that reports this interaction (PMID 11099500)
37

Data Source:
HPRD (two hybrid)

		FHL2	SLC34A1
Gene Name		four and a half LIM domains 2	solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Focal Adhesion Actin Cytoskeleton Z Disc M Band	Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Membrane-bounded Vesicle Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding Androgen Receptor Binding	Protein Binding Symporter Activity Sodium-dependent Phosphate Transmembrane Transporter Activity PDZ Domain Binding Protein Complex Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription, DNA-templated Response To Hormone Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation	Ossification Kidney Development Ion Transport Sodium Ion Transport Phosphate Ion Transport Glycoprotein Metabolic Process Response To Lead Ion Response To Magnesium Ion Response To Estradiol Response To Vitamin A Response To Potassium Ion Indole Metabolic Process Response To Drug Sodium-dependent Phosphate Transport Positive Regulation Of Membrane Potential Response To Cadmium Ion Response To Mercury Ion Bone Remodeling Protein Homooligomerization Phosphate Ion Homeostasis Transmembrane Transport Response To Growth Hormone Cellular Response To Metal Ion Cellular Response To Parathyroid Hormone Stimulus Tricarboxylic Acid Metabolic Process Cellular Response To Staurosporine Response To Thyroid Hormone Dentinogenesis Gentamycin Metabolic Process Arsenate Ion Transmembrane Transport Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Phosphate Transmembrane Transport
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Sodium-coupled phosphate cotransporters Type II Na+/Pi cotransporters Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Nephrolithiasis ( 22396660)
Protein-Protein Interactions		92 interactors: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EIF6 EP300 ESR1 FAM129A FAM154A FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HIF1A ID3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MYBPC1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638	10 interactors: BSPRY FHL2 HPCAL1 HSP90AA1 HSP90AB1 MAST2 PEX19 SLC9A3R1 SLC9A3R2 YIF1A
Entrez ID		2274	6569
HPRD ID		04026	08918
Ensembl ID		ENSG00000115641	ENSG00000131183
Uniprot IDs		J3KNW4 Q14192 Q2XQU9 Q6I9R8	Q06495 Q7Z725 Q86VN6
PDB IDs		1X4K 1X4L 2D8Z
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Transcription, DNA-templated Formation Of Primary Germ Layer Negative Regulation Of Cellular Metabolic Process Tissue Development Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gastrulation Regulation Of Signaling Anatomical Structure Development Response To Organic Substance Organ Morphogenesis Embryonic Morphogenesis	Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Unfolded Protein Regulation Of Cellular Response To Heat Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Folding Intracellular Protein Transmembrane Transport Regulation Of Nitric Oxide Biosynthetic Process Protein Transmembrane Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Heat Renal Phosphate Ion Absorption Negative Regulation Of Lipid Binding Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Response To Heat Atrial Cardiac Muscle Cell Development Peroxisome Membrane Biogenesis Protein Import Into Mitochondrial Outer Membrane Regulation Of Reactive Oxygen Species Metabolic Process Protein Import Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Response To Temperature Stimulus Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Protein Kinase Activity Intracellular Receptor Signaling Pathway Protein Import Into Peroxisome Membrane Chaperone-mediated Protein Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Peroxisomal Membrane Transport Regulation Of Kinase Activity Establishment Of Protein Localization To Membrane Bile Acid Secretion Peroxisome Fission Oligopeptide Transport Regulation Of Binding Phagocytosis Positive Regulation Of Protein Import Into Nucleus, Translocation Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Tagcloud ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Difference) ?		acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Intersection) ?