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FHL2 and WT1
Number of citations of the paper that reports this interaction (PubMedID
12151099
)
0
Data Source:
HPRD
(in vitro, in vivo)
FHL2
WT1
Description
four and a half LIM domains 2
WT1 transcription factor
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Focal Adhesion
Z Disc
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Speck
Molecular Function
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Identical Protein Binding
BHLH Transcription Factor Binding
Metal Ion Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
Protein Binding
Zinc Ion Binding
Double-stranded Methylated DNA Binding
Sequence-specific DNA Binding
Hemi-methylated DNA-binding
Metal Ion Binding
C2H2 Zinc Finger Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Regulation Of Transcription By RNA Polymerase II
Response To Hormone
Negative Regulation Of Apoptotic Process
Atrial Cardiac Muscle Cell Development
Ventricular Cardiac Muscle Cell Development
Heart Trabecula Formation
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Negative Regulation Of Transcription By RNA Polymerase II
Vasculogenesis
Ureteric Bud Development
Branching Involved In Ureteric Bud Morphogenesis
Kidney Development
Regulation Of Animal Organ Formation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Germ Cell Development
Thorax And Anterior Abdomen Determination
Heart Development
Sex Determination
Negative Regulation Of Cell Population Proliferation
RNA Splicing
Gonad Development
Male Gonad Development
Tissue Development
Positive Regulation Of Gene Expression
Negative Regulation Of Translation
Negative Regulation Of Cell Growth
Adrenal Gland Development
Male Genitalia Development
Epithelial Cell Differentiation
Glomerulus Development
Glomerular Basement Membrane Development
Adrenal Cortex Formation
Camera-type Eye Development
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Mesenchymal To Epithelial Transition
Positive Regulation Of Heart Growth
Diaphragm Development
Cardiac Muscle Cell Fate Commitment
Visceral Serous Pericardium Development
Cellular Response To CAMP
Cellular Response To Gonadotropin Stimulus
Metanephric Mesenchyme Development
Nephron Tubule Morphogenesis
Podocyte Differentiation
Posterior Mesonephric Tubule Development
Metanephric Epithelium Development
Metanephric S-shaped Body Morphogenesis
Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation
Circulatory System Development
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Male Gonad Development
Negative Regulation Of Female Gonad Development
Positive Regulation Of Metanephric Ureteric Bud Development
Pathways
PPARA activates gene expression
Transcriptional regulation of testis differentiation
Negative Regulation of CDH1 Gene Transcription
Nephron development
Drugs
Diseases
Nephrotic syndrome and focal segmental glomerulosclerosis
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Appendicular lean mass (
33097823
)
Bipolar disorder x sex interaction (
34099189
)
Body fat mass (
28552196
)
Hip circumference adjusted for BMI (
34021172
)
Household income (MTAG) (
31844048
)
Lung cancer in ever smokers (
28604730
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
Walking pace (
33128006
)
Apolipoprotein A1 levels (
32203549
)
Birth weight (
31043758
)
Brugada syndrome (
35210625
)
Coronary artery disease (
33020668
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Inguinal hernia (
26686553
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (diuretics) (
31015401
)
Offspring birth weight (
31043758
)
Pelvic organ prolapse (
32184442
)
PR interval (
32439900
)
Pulse pressure (
30224653
)
Resting-state electroencephalogram vigilance (
29703947
)
Rubella-specific interleukin-6 secretion (
29253144
)
Tuberculosis (
24057671
22306650
)
Uterine fibroids (
31649266
31249589
30194396
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
175 interacting genes:
A1CF
ABI1
ABLIM1
ADAM17
AK1
AKIP1
AMOT
ANKRD55
APP
AR
ARHGAP9
ATOSB
ATXN1
BANP
BARX2
BIN1
BLZF1
BMPR2
BRCA1
CACNA1C
CAND2
CAPN1
CARD8
CATSPERT
CCDC198
CCDC92
CDC73
CFTR
CIMIP1
CKM
CREBBP
CSK
CSN2
CTNNB1
DAPL1
DCP1A
DDIT4L
DLGAP1
DPF2
DRC4
DTX2
DUSP10
E2F1
E2F2
E2F3
E2F4
EP300
ESR1
FAM204A
FHL1
FHL3
FHL5
FOXO1
GATAD2B
GLYR1
GMEB2
GNG12
GNG4
GOLGA6A
GTF2F2
GTF2H1
HAND1
HCK
HSF2BP
HSPB2
ID3
IDH1
IER3
IFI35
IGFBP5
IKZF1
IKZF4
IL16
INCA1
ITGA3
ITGA7
ITGB1
ITGB2
ITGB5
ITGB6
JUP
KANK2
KIAA1217
KIF5B
KLF12
KLHL20
KPRP
LDLRAP1
LRIF1
MAGEL2
MBD3L1
MCM7
MDM2
MISP
MYBPC1
MYO15B
NBPF6
NIBAN1
NRF1
PFKM
PHB2
PHF1
PHF21A
PKNOX1
PKNOX2
POGZ
POU6F2
PRDM11
PRDM6
PRR5L
PSEN2
PUF60
QRICH1
RAI2
REL
REV1
RFX3
RIPPLY1
RUNX2
SAP30BP
SAXO1
SAXO2
SAXO4
SCNM1
SFPQ
SH3RF1
SIGLEC6
SLAIN1
SLC34A1
SMAD2
SMAD3
SMAD4
SNAI1
SOX30
SP2
SPRY4
SREBF2
SRF
STAT3
SUMO1P1
TCP10L
TNFRSF11A
TOX3
TRAF6
TRIM55
TRIM63
TRIM73
TTN
TXNRD3
VXN
WASHC1
WT1
YPEL3
YY1
ZBTB16
ZBTB25
ZFP64
ZFYVE9
ZMYM4
ZNF131
ZNF143
ZNF200
ZNF212
ZNF23
ZNF3
ZNF331
ZNF408
ZNF410
ZNF417
ZNF620
ZNF626
ZNF638
ZNF655
ZNF85
ZSCAN9
66 interacting genes:
AREG
BHLHE40
CASZ1
CCDC136
CCDC33
CCL5
CEP70
CIAO1
CREBBP
CYSRT1
DIRAS3
DVL2
DVL3
EGR1
ETV7
FAM9B
FHL2
FMR1NB
GLIS2
GOLGA2
HMBOX1
IDI1
IPO8
KLK7
KPNA4
KPNA5
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-4
KRTAP10-5
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP10-9
LDOC1
MAGEA8
MDM2
MYC
NAT2
NPM3
OGT
OSBPL3
PAWR
PAX2
PICK1
PRKACA
RNASEH2B
SERF2
SOX4
STK11
TAOK1
THAP1
THRSP
TP53
TP63
TP73
TRIM55
TRIM63
U2AF2
UBE2I
WTAP
WTIP
YAP1
ZNF205
ZRANB1
Entrez ID
2274
7490
HPRD ID
04026
06163
Ensembl ID
ENSG00000115641
ENSG00000184937
Uniprot IDs
Q14192
Q2XQU9
Q6I9R8
A0A481V744
H0Y7K5
P19544
Q6PI38
PDB IDs
1X4K
1X4L
2D8Z
2MIU
1XF7
2JP9
2JPA
2PRT
3HPJ
3MYJ
4R2E
4R2P
4R2Q
4R2R
4R2S
4WUU
5KL2
5KL3
5KL4
5KL5
5KL6
5KL7
6B0O
6B0P
6B0Q
6B0R
6BLW
6RSY
6WLH
7BBG
8ISN
Enriched GO Terms of Interacting Partners
?
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Binding
Negative Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Negative Regulation Of RNA Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Activity
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Protein Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Positive Regulation Of Macromolecule Metabolic Process
Sequence-specific DNA Binding
Zinc Ion Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
Positive Regulation Of Metabolic Process
Transcription Regulator Complex
Metal Ion Binding
Regulation Of MiRNA Transcription
Sequence-specific Double-stranded DNA Binding
Chromatin
Regulation Of MiRNA Metabolic Process
Nucleoplasm
DNA-templated Transcription
Formation Of Primary Germ Layer
Integrin Complex
Transcription By RNA Polymerase II
RNA Polymerase II Transcription Regulator Complex
Keratin Filament
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Intermediate Filament
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
P53 Binding
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Macromolecule Metabolic Process
Transcription Cis-regulatory Region Binding
Nuclear Body
Nucleoplasm
Regulation Of Transcription By RNA Polymerase II
Cellular Response To Gamma Radiation
Cellular Response To Radiation
Chromatin
Identical Protein Binding
Epithelial Cell Proliferation
Regulation Of Stem Cell Population Maintenance
Regulation Of Somatic Stem Cell Population Maintenance
MDM2/MDM4 Family Protein Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Cellular Response To UV
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Actinomycin D
Cell Population Proliferation
Positive Regulation Of Lymphocyte Apoptotic Process
Nucleus
Regulation Of Intracellular Signal Transduction
Regulation Of Gene Expression
Signal Transduction By P53 Class Mediator
Response To Gamma Radiation
Transcription Factor Binding
Regulation Of Metabolic Process
Regulation Of Signal Transduction
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Positive Regulation Of MiRNA Transcription
Cytosol
Cellular Response To Light Stimulus
Response To Actinomycin D
PML Body
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Tagcloud (Intersection)
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