SH3RF1 and XIRP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH3RF1	XIRP1
Description		SH3 domain containing ring finger 1	xin actin binding repeat containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Lamellipodium Cell Projection Perinuclear Region Of Cytoplasm	Stress Fiber Adherens Junction Focal Adhesion Cell Junction Desmosome Anchoring Junction
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Actin Binding Protein Binding Actin Filament Binding
	Biological Process	MAPK Cascade Neuron Migration Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Response To Aldosterone Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Actin Filament Organization Intracellular Protein Localization Myoblast Differentiation Involved In Skeletal Muscle Regeneration Satellite Cell Activation Involved In Skeletal Muscle Regeneration Actin Cytoskeleton Organization Negative Regulation Of Protein Binding
Pathways		RHOV GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Apolipoprotein A1 levels ( 32203549) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Social communication problems ( 24564958)
Interacting Genes		69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1	9 interacting genes: ACTA1 ENAH EVL FLNC NEB NEBL RNF10 SH3RF1 VASP
Entrez ID		57630	165904
HPRD ID		15335	16727
Ensembl ID		ENSG00000154447	ENSG00000168334
Uniprot IDs		Q7Z6J0	Q702N8
PDB IDs		7NZC 7NZD
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding MAP Kinase Kinase Kinase Activity Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly JUN Kinase Kinase Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Protein Autophosphorylation Ubiquitin Conjugating Enzyme Activity Lamellipodium Negative Regulation Of Membrane Tubulation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Actin Filament-based Process Regulation Of Protein Modification Process Focal Adhesion Ubiquitin-dependent Protein Catabolic Process Protein Serine Kinase Activity Modification-dependent Protein Catabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Proteolysis Involved In Protein Catabolic Process T Cell Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Actin Cytoskeleton Organization Actin Polymerization Or Depolymerization Actomyosin Contractile Ring Assembly JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Apoptotic Process Cell Surface Receptor Signaling Pathway Signal Transduction Protein Polymerization Programmed Cell Death Cell Death Positive Regulation Of Protein Phosphorylation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Protein Phosphorylation Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Cell Communication Protein Modification Process Cytoplasm	Actin Filament Organization Actin Binding Profilin Binding Lamellipodium Supramolecular Fiber Organization Cardiac Muscle Thin Filament Assembly Actin Polymerization Or Depolymerization Filopodium Stress Fiber SH3 Domain Binding Cytoskeleton Z Disc Focal Adhesion Regulation Of Actin Filament Length Actin Filament Binding Neuron Projection Guidance Axon Guidance Structural Constituent Of Muscle Regulation Of Cellular Component Size Positive Regulation Of Actin Filament Polymerization Sarcomere Actin Cytoskeleton Protein Homotetramerization Cytoskeletal Protein Binding Protein Autoubiquitination Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Polymerization Regulation Of Actin Filament-based Process Protein Tetramerization Muscle Cell Development Cytoplasm Regulation Of Actin Filament Polymerization Neuron Projection Development Somatic Muscle Development Mesenchyme Migration Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Skeletal Muscle Thin Filament Assembly Cell Projection Negative Regulation Of Ruffle Assembly Actin Polymerization-dependent Cell Motility Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Schwann Cell Proliferation Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Cytoskeleton Organization Striated Muscle Thin Filament Protein Homooligomerization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
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