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ADAMTSL4 and PRKAB2
Number of citations of the paper that reports this interaction (PMID
24722188
)
1
Data Source:
BioGRID
(two hybrid)
ADAMTSL4
PRKAB2
Gene Name
ADAMTS-like 4
protein kinase, AMP-activated, beta 2 non-catalytic subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cellular_component
Interstitial Matrix
Endoplasmic Reticulum Lumen
Nucleoplasm
Cytosol
AMP-activated Protein Kinase Complex
Molecular Function
Protease Binding
Metalloendopeptidase Activity
Protein Binding
AMP-activated Protein Kinase Activity
Protein Binding
Identical Protein Binding
Biological Process
Protein O-linked Glycosylation
Proteolysis
Apoptotic Process
Extracellular Matrix Organization
Protein O-linked Fucosylation
Positive Regulation Of Apoptotic Process
Post-translational Protein Modification
Cellular Protein Metabolic Process
Energy Reserve Metabolic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Fatty Acid Biosynthetic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Regulation Of Protein Kinase Activity
Membrane Organization
Pathways
Post-translational protein modification
O-glycosylation of TSR domain-containing proteins
O-linked glycosylation
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Drugs
Adenosine monophosphate
Diseases
GWAS
Rhegmatogenous retinal detachment (
23585552
)
Protein-Protein Interactions
106 interactors:
ADAMTSL5
AMMECR1
APOL6
AQP1
ARNT2
ASPSCR1
C19orf66
C6orf165
CATSPER1
CCDC26
CHCHD2
CLEC18A
COL8A1
CPNE7
CREB5
CST2
CTSB
CXCL16
CYP2S1
DGCR6
DIP2A
DLK2
DNPEP
DSCR8
EIF4E2
FAH
FAM124B
FARS2
FBLN1
FBXW5
FHL3
FKBP1B
FLNA
FRS3
GATA2
GIP
GLRX3
GMCL1P1
GNE
GNMT
GOLGA8EP
HGF
HOXA1
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LCE1B
LCE2D
LCE3C
LCE3E
LCE4A
LGALS14
LINC00671
LMO1
LMO2
LONRF1
LRRC29
MAPKBP1
MID2
MORN3
MVP
NATD1
NMUR2
NTF4
NTN4
OLFM3
PID1
PIN1
PLSCR1
PRKAB2
PTGER3
RAB2B
RCHY1
RHOJ
SALL2
SLC23A1
SLC6A20
SMARCC1
SORBS3
SPATA8
SPINK2
SPRY2
STK16
SUSD6
TAPBPL
TCEA2
TMEM150A
TMSB4XP6
TOP3B
TRIM42
TRIP6
TSSK3
TUBGCP4
ZNF417
ZNF587
70 interactors:
ADAMTSL4
BANP
BEND5
BLZF1
CALCOCO2
CASP6
CCDC33
CCDC36
CDX4
CREB3L1
CRX
CSNK2B
DAO
DDIT4L
DICER1
DST
EPM2A
FAM208B
FDX1
FLNC
GATA1
GATAD2B
GET4
GNB2L1
GOLGA2
GRN
IKZF1
IKZF3
KCTD5
KLF15
KRT40
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP9-2
KRTAP9-4
LZTS2
MAGED1
MDFI
MEOX2
NEBL
PIAS2
PRDM14
PRKAA1
PRKAA2
PRKAG1
PRKAG2
PRKAG3
PSME3
PYGM
RBPMS
REL
RHEBL1
RIMBP3
SPRY2
STX11
STX19
TADA2A
TCF4
TP53BP2
TRAF2
TRIM10
UBXN11
YY1AP1
ZBTB32
Entrez ID
54507
5565
HPRD ID
18237
04117
Ensembl ID
ENSG00000143382
ENSG00000131791
Uniprot IDs
F8WAD0
Q6UY14
Q9UFG7
O43741
PDB IDs
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2Y94
2YA3
4EAI
4EAJ
Enriched GO Terms of Interacting Partners
?
Multicellular Organismal Development
Keratinization
Organ Development
Developmental Process
Keratinocyte Differentiation
System Development
Anatomical Structure Development
Epidermis Development
Tissue Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Epidermal Cell Differentiation
Sensory Organ Development
Response To Organic Substance
Organic Anion Transport
Positive Regulation Of Neuron Projection Regeneration
Regulation Of Transcription From RNA Polymerase II Promoter
Epithelium Development
Cellular Response To Thyroid Hormone Stimulus
MRNA Transcription From RNA Polymerase II Promoter
Skin Development
Positive Regulation Of Transcription, DNA-templated
Transepithelial Transport
Semicircular Canal Development
Positive Regulation Of Gene Expression
Regulation Of Branching Involved In Salivary Gland Morphogenesis
MRNA Transcription
Response To Thyroid Hormone
Negative Regulation Of Hydrolase Activity
Cell Differentiation
Negative Regulation Of Protein Metabolic Process
Cellular Response To Organic Substance
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle Arrest
Transcription, DNA-templated
Regulation Of Gene Expression
RNA Biosynthetic Process
Glycogen Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cell Cycle
Energy Reserve Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Polysaccharide Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Organelle Organization
Gene Expression
Cell Cycle Process
Positive Regulation Of Phosphorylation
RNA Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Signaling
Fatty Acid Biosynthetic Process
Cellular Process
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Binding
Regulation Of Metabolic Process
Regulation Of Carbohydrate Metabolic Process
Regulation Of Phosphorylation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Cell Death
Tagcloud
?
abl
baalc
bcr
cd83
ciita
council
ctnnd1
e2993
gab1
gli1
hubs
il15
irs1
p185bcr
p210bcr
pilrb
ptp4a3
rab21
serpinb9
spp1
spry1
supervised
transcriptomic
tspan16
ukall
underexpressed
unsupervised
xbp1
xii
Tagcloud (Difference)
?
abl
baalc
bcr
cd83
ciita
council
ctnnd1
e2993
gab1
gli1
hubs
il15
irs1
p185bcr
p210bcr
pilrb
ptp4a3
rab21
serpinb9
spp1
spry1
supervised
transcriptomic
tspan16
ukall
underexpressed
unsupervised
xbp1
xii
Tagcloud (Intersection)
?