ADAMTSL4 and LCE2D

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ADAMTSL4	LCE2D
Gene Name		ADAMTS-like 4	late cornified envelope 2D
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Interstitial Matrix Endoplasmic Reticulum Lumen
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding
	Biological Process	Protein O-linked Glycosylation Proteolysis Apoptotic Process Extracellular Matrix Organization Protein O-linked Fucosylation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process	Keratinization
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
Drugs
Diseases
GWAS		Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		106 interactors: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 C19orf66 C6orf165 CATSPER1 CCDC26 CHCHD2 CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL1P1 GNE GNMT GOLGA8EP HGF HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587	14 interactors: ADAMTSL4 EFEMP2 GLRX3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 NOTCH2NL OTX1 PLSCR1 RGS20 SPRY1 SPRY2 SUMO1P1
Entrez ID		54507	353141
HPRD ID		18237	17261
Ensembl ID		ENSG00000143382	ENSG00000187223
Uniprot IDs		F8WAD0 Q6UY14 Q9UFG7	Q5TA82
PDB IDs
Enriched GO Terms of Interacting Partners?		Multicellular Organismal Development Keratinization Organ Development Developmental Process Keratinocyte Differentiation System Development Anatomical Structure Development Epidermis Development Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Cell Differentiation Sensory Organ Development Response To Organic Substance Organic Anion Transport Positive Regulation Of Neuron Projection Regeneration Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Cellular Response To Thyroid Hormone Stimulus MRNA Transcription From RNA Polymerase II Promoter Skin Development Positive Regulation Of Transcription, DNA-templated Transepithelial Transport Semicircular Canal Development Positive Regulation Of Gene Expression Regulation Of Branching Involved In Salivary Gland Morphogenesis MRNA Transcription Response To Thyroid Hormone Negative Regulation Of Hydrolase Activity Cell Differentiation Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process	Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Branch Elongation Of An Epithelium Negative Regulation Of GTPase Activity Axis Elongation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Epithelial Tube Branching Involved In Lung Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Spindle Localization Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Lung Morphogenesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of MAP Kinase Activity Inner Ear Morphogenesis Negative Regulation Of Cellular Response To Growth Factor Stimulus Establishment Of Cell Polarity Ear Morphogenesis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Developmental Growth Involved In Morphogenesis Negative Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Or Maintenance Of Cell Polarity Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Process Phosphatidylserine Biosynthetic Process Inner Ear Development Regulation Of ERK1 And ERK2 Cascade Diencephalon Morphogenesis Branching Morphogenesis Of An Epithelial Tube Regulation Of GTPase Activity Negative Regulation Of Protein Kinase Activity Lung Growth Negative Regulation Of Kinase Activity Ear Development Morphogenesis Of A Branching Epithelium Lung Development Morphogenesis Of A Branching Structure Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Tagcloud ?		abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Difference) ?		abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Intersection) ?