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PRKAB2 and PIAS2
Number of citations of the paper that reports this interaction (PMID
24722188
)
1
Data Source:
BioGRID
(two hybrid, two hybrid)
PRKAB2
PIAS2
Gene Name
protein kinase, AMP-activated, beta 2 non-catalytic subunit
protein inhibitor of activated STAT, 2
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytosol
AMP-activated Protein Kinase Complex
Nucleus
PML Body
Nuclear Speck
Molecular Function
AMP-activated Protein Kinase Activity
Protein Binding
Identical Protein Binding
DNA Binding
Transcription Coactivator Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Binding
Androgen Receptor Binding
SUMO Ligase Activity
Biological Process
Energy Reserve Metabolic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Fatty Acid Biosynthetic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Regulation Of Protein Kinase Activity
Membrane Organization
Transcription, DNA-templated
Protein Sumoylation
Androgen Receptor Signaling Pathway
Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Drugs
Adenosine monophosphate
Diseases
GWAS
Protein-Protein Interactions
70 interactors:
ADAMTSL4
BANP
BEND5
BLZF1
CALCOCO2
CASP6
CCDC33
CCDC36
CDX4
CREB3L1
CRX
CSNK2B
DAO
DDIT4L
DICER1
DST
EPM2A
FAM208B
FDX1
FLNC
GATA1
GATAD2B
GET4
GNB2L1
GOLGA2
GRN
IKZF1
IKZF3
KCTD5
KLF15
KRT40
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP9-2
KRTAP9-4
LZTS2
MAGED1
MDFI
MEOX2
NEBL
PIAS2
PRDM14
PRKAA1
PRKAA2
PRKAG1
PRKAG2
PRKAG3
PSME3
PYGM
RBPMS
REL
RHEBL1
RIMBP3
SPRY2
STX11
STX19
TADA2A
TCF4
TP53BP2
TRAF2
TRIM10
UBXN11
YY1AP1
ZBTB32
68 interactors:
ACY3
ADA
AKT1
AR
C1QA
CCHCR1
CCNDBP1
CHMP4B
CLDN2
CTBP1
DDX39B
ELK1
ESR1
ESR2
FLI1
GFAP
GFI1
GLUL
GOLGA2
GRM8
GTF2I
GTF2IRD1
HDAC3
HUWE1
ITGB5
JUN
MAPK8
MAPKAPK2
MBD1
MITF
MSX2
MX2
MYCN
NAV2
NR3C1
PARK7
PAXIP1
PGR
PHC1
PIAS1
PIAS4
PLAG1
PLAGL1
PML
PRKAB2
RUFY1
SIAH1
SIAH2
SMAD3
SMAD4
SNIP1
SREBF2
STAT4
SUMO1
SUMO1P1
SUMO2
SUMO3
TICAM2
TP53
TRIM23
TRIM27
TRIM55
TRIM63
TSR2
UBE2I
ZBED1
ZBTB8A
ZNF451
Entrez ID
5565
9063
HPRD ID
04117
06944
Ensembl ID
ENSG00000131791
ENSG00000078043
Uniprot IDs
O43741
O75928
PDB IDs
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2Y94
2YA3
4EAI
4EAJ
2ASQ
4FO9
Enriched GO Terms of Interacting Partners
?
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle Arrest
Transcription, DNA-templated
Regulation Of Gene Expression
RNA Biosynthetic Process
Glycogen Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cell Cycle
Energy Reserve Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Polysaccharide Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Organelle Organization
Gene Expression
Cell Cycle Process
Positive Regulation Of Phosphorylation
RNA Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Signaling
Fatty Acid Biosynthetic Process
Cellular Process
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Binding
Regulation Of Metabolic Process
Regulation Of Carbohydrate Metabolic Process
Regulation Of Phosphorylation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Cell Death
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Cellular Response To Organic Substance
Transcription, DNA-templated
Response To Organic Substance
RNA Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
RNA Metabolic Process
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Protein Sumoylation
Negative Regulation Of Nucleic Acid-templated Transcription
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Death
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Gland Development
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Protein Modification By Small Protein Conjugation
Cellular Response To Lipid
Macromolecule Biosynthetic Process
Cellular Response To Stimulus
Regulation Of Cellular Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Cellular Metabolic Process
Cellular Response To Organic Cyclic Compound
Regulation Of Cell Proliferation
Regulation Of Signaling
Signaling
Tagcloud
?
293t
acts
alphaclass
androgen
ar
chaperone
clone27
coimmunoprecipitation
colocalization
coregulator
cytoplasm
e3
factorkappab
hek
hela
libraries
ligase
modulates
prefoldintype
sumoylation
termed
transcript
transducer
trapped
twohybrid
ubiquitously
uxt
yeast
Tagcloud (Difference)
?
293t
acts
alphaclass
androgen
ar
chaperone
clone27
coimmunoprecipitation
colocalization
coregulator
cytoplasm
e3
factorkappab
hek
hela
libraries
ligase
modulates
prefoldintype
sumoylation
termed
transcript
transducer
trapped
twohybrid
ubiquitously
uxt
yeast
Tagcloud (Intersection)
?