ADAMTSL4 and CHERP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADAMTSL4	CHERP
Description		ADAMTS like 4	calcium homeostasis endoplasmic reticulum protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Interstitial Matrix Endoplasmic Reticulum Lumen Extracellular Matrix	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Protein Binding Identical Protein Binding	Nucleic Acid Binding RNA Binding Protein Binding Transmembrane Transporter Binding
	Biological Process	Epithelial Cell Development Apoptotic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process Pigment Cell Development	RNA Processing Intracellular Calcium Ion Homeostasis Nervous System Development Negative Regulation Of Cell Population Proliferation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	mRNA Splicing - Major Pathway
Drugs
Diseases		Ectopia lentis
GWAS		Appendicular lean mass ( 33097823) Asthma ( 32296059) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Migraine ( 27322543) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		212 interacting genes: ADAM12 ADAMTSL5 ALPP AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 ATG9A BAG4 BANF2 BOLA2 BOLA2B BRME1 CATSPER1 CBX3 CCDC26 CFAP206 CHCHD2 CHERP CHIC2 CHRD CHRNG CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 CYSRT1 DGCR6 DGCR6L DIP2A DLK2 DNPEP DSCR8 EFEMP2 EIF4E2 EPDR1 ERCC3 EXOSC5 FAH FAM124B FARS2 FBLN1 FBXL9P FBXO17 FBXW5 FHL3 FKBP1B FLNA FRS3 FXR1 GATA2 GIP GLRX3 GLYCTK GMCL2 GNE GNG13 GNMT GOLGA8EP GSTP1 GUCD1 HEXIM2 HGF HNRNPLL HOXA1 HOXC8 HSD3B7 INS IP6K1 ITGB2 ITGB4 JOSD1 KCTD7 KCTD9 KIF1A KLHL38 KRTAP1-1 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP19-2 KRTAP21-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LGALS14 LHX4 LINC00671 LMO1 LMO2 LMO4 LNX1 LONRF1 LRFN4 MAGOHB MAPKBP1 MGAT5B MID2 MKRN3 MORN3 MVP MYLIP MYO15B NATD1 NBPF19 NEK8 NFKBID NMUR2 NOTCH2NLA NR4A3 NTAQ1 NTF4 NTN4 NUFIP2 OLFM3 OTX1 PCSK5 PID1 PIN1 PKN1 PLSCR1 PLSCR4 POLD1 POLR1C POU4F2 PRKAB2 PRR19 PTGER3 PTPMT1 QPRT R3HDM2 RAB2B RCHY1 RGL2 RHOJ RPS19BP1 RUNX1T1 SALL2 SCNM1 SHFL SLC13A5 SLC23A1 SLC6A20 SLIT1 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY1 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TFAP2D TGFB1 THAP6 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIM55 TRIM63 TRIP6 TSSK3 TUBGCP4 USP21 VASN VENTX VWC2 ZFHX2 ZNF330 ZNF414 ZNF417 ZNF587	48 interacting genes: ADAMTSL4 AGGF1 APBB1 ARGLU1 C1orf94 CCAR1 CLK3 EWSR1 FASTK FIGN FRA10AC1 HNRNPH3 KRTAP11-1 LASP1 LUC7L MAGED1 MECOM MIR106B MIR200C MIR363 MIRLET7A2 MIRLET7C MIRLET7D MIRLET7E MIRLET7G MIRLET7I PPIL4 PRPF38A PRPF40A RACK1 RBFOX2 RBM23 RBM39 RBM7 RNPS1 SART1 SAXO1 SF3B4 SNRNP27 SNRNP70 SORBS3 SRPK1 SRPK2 TLE3 TTC14 U2AF1 USP54 WBP4
Entrez ID		54507	10523
HPRD ID		18237	13051
Ensembl ID		ENSG00000143382	ENSG00000085872
Uniprot IDs		A0A669KBE7 B7ZMJ3 Q6UY14	Q8IWX8
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratinization Keratin Filament Epidermis Development Protein Binding Tissue Development Identical Protein Binding Hair Cycle	RNA Splicing MRNA Processing Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions RNA Binding Regulation Of MRNA Splicing, Via Spliceosome MiRNA-mediated Post-transcriptional Gene Silencing Nucleic Acid Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Nuclear Speck Regulation Of MRNA Processing RISC Complex Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing RNA Metabolic Process Spliceosomal Complex RS Domain Binding U1 SnRNP Binding Post-transcriptional Regulation Of Gene Expression Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process MRNA Cis Splicing, Via Spliceosome U2-type Precatalytic Spliceosome U2-type Prespliceosome Negative Regulation Of Macromolecule Biosynthetic Process U1 SnRNP Precatalytic Spliceosome Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Interleukin-6-mediated Signaling Pathway Extracellular Vesicle Nucleobase-containing Compound Metabolic Process MRNA Destabilization RNA Destabilization Regulation Of MRNA Stability Regulation Of RNA Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Gene Expression
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